Nontypable Haemophilus influenzae: A Review of Clinical Aspects, Surface Antigens, and the Human Immune Response to Infection

Bacterial Adherence: Adhesin-Receptor Interactions Mediating the Attachment of Bacteria to Mucosal Surfaces

1981 • 1,486 citations

HUMAN IMMUNITY TO THE MENINGOCOCCUS

1969 • 1,290 citations

A Taxonomic Study of the Genus Haemophilus, with the Proposal of a New Species

1976 • 730 citations

Haemophilus influenzae Type b Capsular Polysaccharide Vaccine in Children: A Double-Blind Field Study of 100,000 Vaccinees 3 Months to 5 Years of Age in Finland

1977 • 495 citations

Polymicrobial Etiology of Acute Pelvic Inflammatory Disease

1975 • 477 citations

Acute Maxillary Sinusitis in Children

1981 • 450 citations

Epidemiology of Otitis Media in Children

1980 • 444 citations

Role of Infection in Chronic Bronchitis

1975 • 424 citations

Sinusitis of the Maxillary Antrum

1975 • 381 citations

Prevention ofHemophilus influenzaeType B Bacteremic Infections with the Capsular Polysaccharide Vaccine

1984 • 349 citations

Influenzal Meningitis The Relation of Age Incidence to the Bactericidal Power of Blood Against the Causal Organism

1933 • 340 citations

Subtyping Isolates of Haemophilus influenzae Type b by Outer-Membrane Protein Profiles

1981 • 335 citations

Effects of Heating in Dodecyl Sulfate Solution on the Conformation and Electrophoretic Mobility of Isolated Major Outer Membrane Proteins from Escherichia coli K-121

1976 • 264 citations

A Half Century of Neonatal Sepsis at Yale

1981 • 252 citations

Bacteriologic Flora of the Lower Respiratory Tract

1961 • 237 citations

Bacterial Pneumonia in the Elderly

1983 • 233 citations

Tubal and cervical cultures in acute salpingitis with special reference to Mycoplasma hominis and T-strain mycoplasmas.

1970 • 203 citations

Outer Membrane Protein Composition in Disease Isolates of Haemophilus influenzae : Pathogenic and Epidemiological Implications

1980 • 201 citations

Pneumonia and Acute Febrile Tracheobronchitis Due to Haemophilus influenzae

1983 • 192 citations

Studies on gonococcus infection. XIV. Cell wall protein differences among color/opacity colony variants of Neisseria gonorrhoeae

1978 • 191 citations

Electrophoretic Heterogeneity and Interstrain Variation of the Lipopolysaccharide of Haemophilus influenzae

1983 • 184 citations

Outer membrane proteins of Brucella abortus: isolation and characterization

1982 • 182 citations

Characterization of non-beta-lactamase-mediated ampicillin resistance in Haemophilus influenzae

1984 • 175 citations

Outer membrane proteins of Escherichia coli

1973 • 172 citations

Antibiotic Therapy of Acute Exacerbations of Chronic Bronchitis

1982 • 171 citations

A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae.

1985 • 157 citations

A Subtyping System for Nontypable Haemophilus influenzae Based on Outer-Membrane Proteins

1983 • 156 citations

BACTERIOLOGY OF LOWER-RESPIRATORYTRACT SECRETIONS, SPUTUM, AND UPPER-RESPIRATORY-TRACT SECRETIONS IN " NORMALS " AND CHRONIC BRONCHITICS

1959 • 151 citations

Purification and partial characterization of outer membrane proteins P5 and P6 from Haemophilus influenzae type b

1985 • 143 citations

Bacteremic hemophilus influenzae pneumonia in adults

1977 • 143 citations

Hemophilus influenzae pneumonia in adults

1978 • 141 citations

Use of laparoscopy to determine the microbiologic etiology of acute salpingitis

1979 • 140 citations

Haemophilus Influenzae Infections in Adults: Report of Nine Cases and a Review of the Literature

1979 • 136 citations

Colony opacity and protein II compositions of gonococci

1982 • 136 citations

Outer membrane protein and biotype analysis of pathogenic nontypable Haemophilus influenzae

1982 • 131 citations

AN EVALUATION OF SPUTUM EXAMINATION IN CHRONIC BRONCHITIS

1957 • 129 citations

Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody.

1986 • 128 citations

Bacterial Flora of the Upper Respiratory Tract in Paddington Families, 1952-4

1958 • 126 citations

DO PILI PLAY A ROLE IN PATHOGENICITY OF HAEMOPHILUS INFLUENZAE TYPE B?

1982 • 122 citations

Prophylactic Use of Oxytetracycline for Exacerbations of Chronic Bronchitis

1957 • 115 citations

Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates.

1983 • 114 citations

THE BACTERIOLOGY OF CHRONIC BRONCHITIS

1953 • 109 citations

Antibody response of infants to cell surface-exposed outer membrane proteins of Haemophilus influenzae type b after systemic Haemophilus disease

1982 • 106 citations

A minor high-molecular-weight outer membrane protein of Haemophilus influenzae type b is a protective antigen

1985 • 105 citations

Haemophilus influenzae type b: Disease and Immunity in Humans

1973 • 102 citations

Characteristics of major outer membrane proteins of Haemophilus influenzae

1983 • 101 citations

Nontypeable Haemophilus influenzae in the Elderly

1982 • 100 citations

Value of ampicillin in the hospital treatment of exacerbations of chronic bronchitis.

1965 • 99 citations

MENINGITIS FOLLOWING TRAUMA TO THE HEAD AND FACE

1960 • 99 citations

Adherence of Piliated Haemophilus influenzae Type b to Human Oropharyngeal Cells

1982 • 99 citations

Identification of a Specific Epitope of Haemophilus influenzae on a 16,600-Dalton Outer Membrane Protein

1985 • 95 citations

Bactericidal antibody and susceptibility to otitis media caused by nontypable strains of Haemophilus influenzae

1980 • 95 citations

Antibiotic regimens in moderately ill patients with purulent exacerbations of chronic bronchitis

1972 • 94 citations

Bacterial flora of the respiratory tract in chronic bronchitis: comparison of transtracheal, fiberbronchoscopic, and oropharyngeal sampling methods.

1977 • 93 citations

Biotypes of Haemophilus encountered in clinical laboratories

1979 • 92 citations

A study of infective and other factors in exacerbations of chronic bronchitis

1980 • 87 citations

Biochemical characteristics of 130 recent isolates from Haemophilus influenzae meningitis

1979 • 87 citations

Antibiotic regimens in severe and acute purulent exacerbations of chronic bronchitis.

1968 • 85 citations

Characterization of Haemophilus influenzae type b fimbriae

1984 • 83 citations

Haemophilus influenzaeInfections

1983 • 80 citations

Outer-Membrane Protein Subtypes of Haemophilus influenzae Type band Spread of Disease in Day-Care Centers

1981 • 80 citations

A rapid method for the differentiation of Haemophilus strains. The porphyrin test.

1974 • 79 citations

Haemophilus influenzae Pneumonia in Adults

1977 • 77 citations

Modification of Otitis Media in Chinchillas Rechallenged with Nontypable Haemophilus influenzae and Serological Response to Outer Membrane Antigens

1985 • 76 citations

EXACERBATIONS OF CHRONIC BRONCHITIS TREATMENT WITH OXYTETRACYCLINE

1960 • 76 citations

Characterization of antigens from nontypable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins.

1985 • 75 citations

HÆMOPHILUS INFLUENZÆ PRECIPITINS IN THE SERUM OF PATIENTS WITH CHRONIC BRONCHIAL DISORDERS

1967 • 74 citations

Frequency and properties of naturally occurring adherent piliated strains of Haemophilus influenzae type b

1985 • 73 citations

Acute epiglottitis in adults: Experience with fifteen cases

1980 • 72 citations

Hemophilus influenzae in hospitalized adults: Current perspectives

1980 • 72 citations

Biochemical characteristics of Haemophilus influenzae in relationship to source of isolation and antibiotic resistance

1978 • 70 citations

Haemophilus influenzaeMeningitis in an Adult

1970 • 69 citations

Opsonizing and bactericidal effects of normal human serum on nontypable Haemophilus influenzae

1983 • 68 citations

Isolation and partial characterization of outer and inner membranes from encapsulated Haemophilus influenzae type b.

1981 • 68 citations

Five-year winter chemoprophylaxis for chronic bronchitis

1969 • 67 citations

The Role of Encapsulation and Host Age in the Clearance of Haemophilus influenzae Bacteremia

1977 • 66 citations

Bacterial adherence to pharyngeal cells in smokers, nonsmokers, and chronic bronchitics

1979 • 66 citations

IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN

1982 • 65 citations

Neonatal Haemophilus influenzae Infection

1975 • 65 citations

Coprecipitation of lipopolysaccharide and the 39,000-molecular-weight major outer membrane protein of Haemophilus influenzae type b by lipopolysaccharide-directed monoclonal antibody

1985 • 64 citations

Pilot study of factors associated with exacerbations in chronic bronchitis

1969 • 64 citations

Haemophilus influenzae Meningitis

1982 • 63 citations

A Hemadsorption Method for Detection of Colonies of Haemophilus influenzas Type b Expressing Fimbriae

1983 • 62 citations

Meningitis and Bacteremia due to Haemophilus influenzae: Occurrence and Mortality at Boston City Hospital in 12 Selected Years, 1935-1972

1974 • 62 citations

Antigenic heterogeneity of outer membrane proteins of nontypable Haemophilus influenzae is a basis for a serotyping system

1985 • 61 citations

SPUTUM IN CHRONIC BRONCHITIS EFFECTS OF ANTIBIOTICS

1953 • 61 citations

ANTIBIOTICS IN CHRONIC BRONCHITIS

1953 • 59 citations

Evaluation of Continuous Antibiotic Therapy in Chronic Bronchitis

1959 • 58 citations

Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis

1969 • 57 citations

Chemotherapy in Chronic Bronchitis: Report of the British Tuberculosis Association

1960 • 54 citations

Role of Immunity in the Clearance of Bacteremia Due to Haemophilus influenzae

1978 • 54 citations

Systemic infection with Hemophilus influenzae in very young infants

1967 • 53 citations

The association of bacteremic Haemophilus influenzae pneumonia in adults with typable strains

1971 • 53 citations

Variable adherence of fimbriated Haemophilus influenzae type b to human cells

1985 • 52 citations

Experimental Haemophilus influenzae Type b Meningitis: Immunological Investigation of the Infant Rat Model

1978 • 52 citations

Bacteremic Haemophilus influenzae Genitourinary Tract Infections in Adults

1978 • 51 citations

Human Antibody Responses to Lipopolysaccharide after Meningitis Due to Haemophilus influenzae Type b

1982 • 48 citations

Haemophilus influenzae Meningitis in Adults

1974 • 48 citations

Use of the Minitek system for biotyping Haemophilus species

1978 • 48 citations

Further studies of the role of noncapsular antibody in protection against experimental Haemophilus influenzae type b bacteremia

1983 • 48 citations

Human Antibody Response to Individual Outer Membrane Proteins of Haemophilus influenzae Type b

1982 • 47 citations

Long-Term Treatment of Bronchiectasis and Chronic Bronchitis

1959 • 46 citations

Protection from Infection with Haemophilus influenzae Type b by Monoclonal Antibody to the Capsule

1982 • 45 citations

Constitution of the cell envelope of Haemophilus influenzae in relation to competence for genetic transformation

1975 • 45 citations

Hemophilus Influenzae

1968 • 44 citations

Antigenic heterogeneity of lipid A of Haemophilus influenzae

1985 • 41 citations

Immunoglobulin A from bronchopulmonary secretions blocks bactericidal and opsonizing effects of antibody to nontypable Haemophilus influenzae

1984 • 41 citations

Antibodies to Haemophilus Influenzae in Chronic Bronchitis

1959 • 40 citations

THE ISOLATION AND IDENTIFICATION OF HAEMOPHILUS SPP. FROM UNUSUAL LESIONS IN CHILDREN

1960 • 40 citations

Hemophilus Influenzae Infections in Adults

1978 • 38 citations

Haemophilus Epiglottitis: Nine Recent Cases in Oxford

1972 • 38 citations

Hemophilus influenzae pericarditis

1973 • 38 citations

Immunity to Haemophilus influenzae Type b in Young Adults: Correlation of Bactericidal and Opsonizing Activity of Serum with Antibody to Polyribosylribitol Phosphate and Lipooligosaccharide Before and After Vaccination

1986 • 38 citations

Haemophilus Influenzae Infections Of The Genital Tract

1971 • 36 citations

Biotypes of Haemophilus influenzae: Relationship to Clinical Source of Isolation, Serotype, and Antibiotic Susceptibility

1983 • 36 citations

Role of adherence in the pathogenesis of Haemophilus influenzae type b infection in infant rats

1983 • 35 citations

Serum and secretory antibodies in patients with chronic bronchitis.

1973 • 35 citations

Early-Onset Haemophilus Sepsis in Newborn Infants: Clinical, Roentgenographic, and Pathologic Features

1978 • 35 citations

EFFECT OF ANTIBIOTICS ON PURULENT SPUTUM

1957 • 34 citations

Antibody responses to bacterial antigens during exacerbations of chronic bronchitis.

1970 • 33 citations

Fimbriation of Haemophilus Species Isolated from the Respiratory Tract of Adults

1984 • 32 citations

Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema

1961 • 32 citations

CAPSULATED HÆMOPHILUS INFLUENZÆ AND RESPIRATORY-TRACT DISEASE

1967 • 32 citations

Haemophilus influenzae as a Cause of Adult Pneumonia

1967 • 31 citations

HÆMOPHILUS INFLUENZÆ IN SEPTIC ABORTION

1973 • 29 citations

LONG-TERM PROPHYLACTIC ADMINISTRATION OF TETRACYCLINE TO CHRONIC BRONCHITICS

1958 • 29 citations

A COMPARATIVE STUDY OF AMPICILLIN, TETRACYCLINE HYDROCHLORIDE, AND METHACYCLINE HYDROCHLORIDE IN ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS

1968 • 29 citations

Congenital Vesicular Eruption Caused by Haemophilus influenzae Type b

1978 • 28 citations

Outer membrane proteins of nontypable Haemophilus influenzae and reactivity of paired sera from infected patients with their homologous isolates

1985 • 28 citations

Fulminant neonatal Hemophilus influenzae pneumonia and sepsis

1978 • 27 citations

HEMOPHILUS INFLUENZAE BACTEREMIA: REPORT OF TWO CASES RECOVERING FOLLOWING SULFATHIAZOLE AND SULFAPYRIDINE

1942 • 26 citations

A study of Hemophilus influenzae precipitins in the serum of working men in relation to smoking habits, bronchial infection, and airway obstruction.

1973 • 26 citations

Significance of noncapsular antigens in protection against experimental Haemophilus influenzae type b disease: cross-reactivity

1978 • 26 citations

Chronic bronchitis

1961 • 26 citations

Acute epiglottitis in adults.

1981 • 25 citations

Hemophilus influenzae meningitis in adults. Review of the literature and report of 18 cases.

1965 • 25 citations

A Trial of Phenethicillin in Chronic Bronchitis

1961 • 25 citations

Hemophilus influenzae septic arthritis. A mimicker of gonococcal arthritis

1974 • 25 citations

Controlled trials of a sulphonamide given weekly to prevent exacerbations of chronic bronchitis.

1967 • 24 citations

HEMOPHILUS INFLUENZAE MENINGITIS IN A PREMATURE INFANT.

1965 • 24 citations

The bacterial flora of the upper respiratory tract and sputum of working men

1964 • 24 citations

Urinary tract infection due to Hemophilus influenzae, type b

1974 • 24 citations

Postpartum bacteremia due to Haemophilus influenzae. Report of two cases.

1969 • 24 citations

Neonatal Hemophilus influenzae Septicemia

1970 • 24 citations

A TRIAL OF CONTINUOUS WINTER CHEMOTHERAPY IN CHRONIC BRONCHITIS

1960 • 23 citations

Tubo-ovarian abscess caused by a non-capsulated strain of Haemophilus influenzae.

1970 • 23 citations

Isolation of Haemophilus in urine cultures from children

1979 • 23 citations

Infectious Arthritis in the Neonate Caused by Haemophilus influenzae

1975 • 23 citations

SERUM BACTERICIDAL EFFECT ON CAPSULATED AND NON‐CAPSULATED HAEMOPHILUS INFLUENZAE

1980 • 22 citations

Hemophilus influenzae Type b Sepsis in Infant and Mother

1976 • 22 citations

Hemophilus influenzaePneumonia in Adults

1980 • 21 citations

Bactericidal Antibodies to Hemophilus influenzae

1971 • 20 citations

A Polysaccharide-Protein Complex from Haemophilus influenzae Type b. II. Human Antibodies to Its Somatic Components

1981 • 20 citations

Haemophilus influenzae type b isolates show antigenic variation in a major outer membrane protein

1984 • 20 citations

Reevaluafion of Neonatal Hemophilus influenzae Infections

1977 • 19 citations

Case Report Haemophilus influenzae septic arthritis in adults

1980 • 18 citations

Haemophilus influenzae Pericarditis and Empyema With Thyroiditis in an Adult

1974 • 18 citations

Hemophilus influenzae pneumonia in adults. Report of five cases and review of the literature.

1968 • 17 citations

Mannose-resistant and eluting (MRE) haemagglutinins, fimbriae and surface structure in strains ofHaemophilus

1981 • 16 citations

Perinatal infections caused by Haemophilus influenzae.

1975 • 16 citations

Hemophilus influenzae infection in the neonate mimicking respiratory distress syndrome

1978 • 16 citations

Chemical composition and biological activities of a phenol-water extract from Haemophilus influenzae type a

1979 • 16 citations

Hemophilus influenzae , Type b, Antibody Frequencies Determined with Bactericidal and Radioimmunoassay Tests

1975 • 15 citations

Immunology of the infant rat experimental model of Haemophilus influenzae type b meningitis

1977 • 15 citations

Cholecystitis Associated with Haemophilus influenzae

1972 • 15 citations

Chloramphenicol and ampicillin compared in elderly patients with severe purulent exacerbations of bronchitis

1972 • 14 citations

Nontypable Haemophilus influenzae are Unencapsulated both in Vivo and in Vitro

1984 • 13 citations

Penicillin, ampicillin and cephaloridine in severe exacerbations of purulent chronic bronchitis in elderly patients

1971 • 12 citations

Characteristics of a lipid preparation (lipid A) from Haemophilus influenzae type a lipopolysaccharide

1981 • 12 citations

Neonatal Meningitis and Mastoiditis Caused by Hemophilus influenzae

1976 • 12 citations

Hemophilus influenzae pericarditis with cardiac tamponade

1973 • 11 citations

Hemophilus influenza septicemia and midtrimester abortion.

1979 • 11 citations

Antibody responses to capsular polysaccharide, lipopolysaccharide, and outer membrane in adults infected with Haemophilus influenzae type b

1984 • 11 citations

Heterogeneity of lipid A: comparison of lipid A types from different gram-negative bacteria

1984 • 11 citations

Preparation of a nontoxic and immunogenic polysaccharide fraction from a Haemophilus influenzae phenol-water extract

1980 • 10 citations

Posttraumatic meningitis due to ampicillin-resistant Hemophilus influenzae

1979 • 10 citations

Induction of active immunity with membrane fractions from Haemophilus influenzae type b

1983 • 10 citations

CEPHALORIDINE COMPARED WITH PENICILLIN AND STREPTOMYCIN IN EXACERBATIONS OF CHRONIC MUCOPURULENT BRONCHITIS

1968 • 9 citations

Intrauterine Infection by Non-capsulated Haemophilus Influenzae in a Case of Maternal Immunodeficiency

1980 • 9 citations

SPUTUM IN CHRONIC BRONCHITIS

1958 • 9 citations

Bactericidal antibodies against noncapsular components of Haemophilus influenzae

1983 • 9 citations

Bacterial infection and some effects of Chemoprophylaxis in chronic pulmonary emphysema. II. chemoprophylaxis with daily chloramphenicol.

1965 • 8 citations

Two Cases of Septicemia Caused by Noncapsulated Strains of Haemophilus Influenzae

1978 • 8 citations

Functional and ultrastructural effects of nontypeable haemophilus influenzae in a hamster trachea organ culture system

1985 • 8 citations

AMPICILLIN IN HIGH DOSAGE IN PERSISTENT INFECTIONS OF THE BRONCHI

1964 • 8 citations

CHARACTERIZATION OF THE BACTERICIDAL ANTIBODY RESPONSE AGAINST HAEMOPHILUS INFLUENZAE

1980 • 7 citations

Serum bactericidal effect on capsulated and non-capsulated Haemophilus influenzae in chronic sinusitis

1984 • 6 citations

A double-blind cross-over trial of trimethoprim and sulphamethoxazole in chronic bronchitis

1971 • 4 citations

Acute epiglottitis and systemic infection with Hemophilus influenzae.

1978 • 4 citations