Rheological Properties and Hydration of Airway Mucus

Viscoelastic Properties of Polymers

1961 • 13,533 citations

Viscoelastic Properties of Polymers

1981 • 11,092 citations

Gels

1981 • 875 citations

The Theory of Membrane Equilibria.

1924 • 737 citations

Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.

1990 • 696 citations

The Propulsion of Mucus by Cilia

1988 • 548 citations

Defective acidification of intracellular organelles in cystic fibrosis

1991 • 490 citations

Cellular and Biochemical Analysis of Induced Sputum from Asthmatic and from Healthy Subjects

1993 • 429 citations

A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis

1990 • 348 citations

Exocytosis

1990 • 260 citations

Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis.

1989 • 216 citations

Role of the physiochemical properties of mucus in the protection of the respiratory epithelium

1992 • 210 citations

Reduction in Viscosity of Cystic Fibrosis Sputum in Vitro by Gelsolin

1994 • 207 citations

The exocytotic fusion pore.

1992 • 195 citations

Acute and Long-term Amiloride Inhalation in Cystic Fibrosis Lung Disease: A Rational Approach to Cystic Fibrosis Therapy

1990 • 184 citations

Mucus in Health and Disease

1977 • 178 citations

Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis.

1996 • 169 citations

Control of mucus hydration as a Donnan equilibrium process

1981 • 145 citations

Mucin Exocytosis

1991 • 140 citations

No added benefit from nebulized amiloride in patients with cystic fibrosis

1993 • 139 citations

Molecular Mechanism of Mucin Secretion: I. The Role of Intragranular Charge Shielding

1987 • 136 citations

In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis.

1996 • 135 citations

Direct effect of bile salts and phospholipids on the physical properties of mucus.

1978 • 131 citations

Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus.

1995 • 123 citations

Pus, deoxyribonucleic acid, and sputum viscosity.

1978 • 115 citations

Markers of Mucus Secretion and DNA Levels in Induced Sputum from Asthmatic and from Healthy Subjects

1993 • 104 citations

The role of mucus gel viscosity, spinnability, and adhesive properties in clearance by simulated cough

1989 • 103 citations

Rheological properties of microliter quantities of normal mucus

1977 • 103 citations

Rheology of Biological Systems

1974 • 100 citations

Mucus and related topics.

1989 • 100 citations

Reversible condensation of mast cell secretory products in vitro

1991 • 98 citations

Amiloride Inhalation Therapy in Cystic Fibrosis: Influence on Ion Content, Hydration, and Rheology of Sputum

1993 • 93 citations

Morphometric Analysis of Intraluminal Mucus in Airways in Chronic Obstructive Pulmonary Disease

1989 • 89 citations

Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease.

1996 • 87 citations

Inhibition by Oral N-Acetylcysteine of Cigarette Smoke-Induced “Bronchitis” in the Rat

1986 • 85 citations

Cystic Fibrosis: Projections into the Future

1977 • 84 citations

Hydration Kinetics of Exocytosed Mucins in Cultured Secretory Cells of the Rabbit Trachea: A New Model

1984 • 84 citations

Fluid and Electrolyte Abnormalities in Exocrine Glands in Cystic Fibrosis

1983 • 83 citations

Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases.

1978 • 83 citations

Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca++

1987 • 82 citations

Calcium binding to intestinal goblet cell mucin

1975 • 81 citations

An Elastic Value of Protoplasm, with Further Observations on the Viscosity of Protoplasm

1924 • 79 citations

Studies on pulmonary secretions. II. Osmolality and the ionic environment of pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy.

1967 • 77 citations

The Radioimmunoassay of Pulmonary Surface Active Material in Sheep Lung^1–3

1974 • 75 citations

Exogenous surfactant enhances mucociliary clearance in the anaesthetized dog

1994 • 73 citations

Dose-dependent in vitro effect of recombinant human DNase on rheological and transport properties of cystic fibrosis respiratory mucus

1995 • 73 citations

Effects of Orally Administered Drugs on Dynamic Viscoelasticity of Human Nasal Mucus

1990 • 70 citations

Role of simulated repetitive coughing in mucus clearance

1991 • 67 citations

Molecular Arrangement of Cervical Mucus: a Reevaluation Based on Laser Light-Scattering Spectroscopy

1977 • 66 citations

Sputum viscosity in chronic bronchitis, bronchiectasis, asthma and cystic fibrosis

1972 • 66 citations

The Role of Mucous Glycoproteins in the Rheologic Properties of Cystic Fibrosis Sputum

1990 • 64 citations

Effects of oscillating air flow on the rheological properties and clearability of mucous gel simulants

1994 • 61 citations

The Mechanism of Mucus Clearance in Cough

1989 • 59 citations

Counter-ion binding to mucus glycoproteins

1984 • 58 citations

Correlation between rheologic properties and in vitro ciliary transport of rat nasal mucus

1992 • 54 citations

Human Cervical Mucus. III. Isolation and Characterization of Rheologically Active Mucin

1977 • 52 citations

Mucus transport in a miniaturized simulated cough machine: Effect of constriction and serous layer simulant

1989 • 52 citations

Mucus Rheology and Transport in Neonatal Respiratory Distress Syndrome and the Effect of Surfactant Therapy

1992 • 49 citations

The rheology of pig small intestinal and colonic mucus: weakening of gel structure by non-mucin components

1991 • 49 citations

Effect of nondialyzable solids concentration and viscoelasticity on ciliary transport of tracheal mucus.

1977 • 46 citations

Addition of a Bacterial Alginate Lyase to Purulent CF Sputum In Vitro Can Result in the Disruption of Alginate and Modification of Sputum Viscoelasticity

1994 • 45 citations

Nebulised amiloride in respiratory exacerbations of cystic fibrosis: a randomised controlled trial.

1995 • 44 citations

Cation induced changes in the rheological properties of purified mucus glycoprotein gels

1984 • 43 citations

Conformational structure of respiratory mucus studied by laser correlation spectroscopy1

1983 • 43 citations

Long-Lasting Effects on Rheology and Clearance of Bronchial Mucus after Short-Term Administration of High Doses of Carbocysteine-Lysine to Patients with Chronic Bronchitis

1990 • 41 citations

Effects of rhDNase on purulent airway secretions in chronic bronchitis

1996 • 41 citations

[Human cervical mucus].

1986 • 41 citations

Rheology of biological systems

1973 • 39 citations

Electron microprobe analysis of human labial gland secretory granules in cystic fibrosis.

1985 • 39 citations

Oral N-acetylcysteine or S-carboxymethylcysteine inhibit cigarette smoke-induced hypersecretion of mucus in rat larynx and trachea in situ

1989 • 33 citations

Effects of erdosteine on sputum biochemical and rheologic properties: Pharmacokinetics in chronic obstructive lung disease

1990 • 32 citations

Rheological determinants of mucociliary transport in the nose of the rat

1995 • 32 citations

N-Acetyl-l-cysteine and its derivatives activate a Cl− conductance in epithelial cells

1996 • 31 citations

Mucociliary transference rate and mucus viscoelasticity dependence on dynamic storage and loss modulus.

1979 • 30 citations

Airway Secretion Physiological Bases for the Control of Mucous Hypersecretion

1995 • 28 citations

Recurrent respiratory infections in a child with fucosidosis: Is the mucus too thin for effective transport?

1991 • 28 citations

Role of phospholipid lining on respiratory mucus clearance by cough

1991 • 27 citations

Therapeutic Aerosols and Airway Secretions

1996 • 27 citations

Cystic fibrosis: Projections into the future

1977 • 26 citations

Molecular mechanism of product storage and release in mucin secretion

1986 • 26 citations

Viscous Airflow Through a Rigid Tube With a Compliant Lining: A Simple Model for the Air-Mucus Interaction in Pulmonary Airways

1993 • 25 citations

Stimulation of Cl- secretion by the mucoactive drug S-carboxymethylcysteine-lysine salt in the isolated rabbit trachea

1994 • 25 citations

Donnan mechanism of mucin release and conditioning in goblet cells: the role of polyions.

1989 • 25 citations

Influence of Two-Phase Gas-Liquid Interaction on Aerosol Deposition in Airways

1985 • 24 citations

Viscoelasticity of anionic polymers and their mucociliary transport on the frog palate.

1993 • 24 citations

OralN-Acetylcysteine Speeds Reversal of Cigarette Smoke-Induced Mucous Cell Hyperplasia in the Rat

1988 • 21 citations

Biopolymer Induced Changes in Mucus Viscoelasticity

1982 • 20 citations

Mucus glycoprotein, its biophysical and gel-forming properties.

1989 • 20 citations

The effect of tetracyclines on the viscoelastic properties of bronchial mucus

1975 • 20 citations

Mucous gel transport in a simulated cough machine: Effects of longitudinal grooves representing spacings between arrays of cilia

1994 • 19 citations

Airway secretion : physiological bases for the control of mucous hypersecretion

1994 • 19 citations

Changes in cervical mucus that prevent penetration by spermatozoa.

1989 • 18 citations

Computer-assisted rheological evaluation of microsamples of mucus

1992 • 15 citations

Airway mucus

1989 • 14 citations

The mucolytic activity of polyamines and mucosal invasion

1994 • 10 citations

A modified oscillating sphere magnetic microrheometer for use with biological secretions

1982 • 10 citations

Compaction assay: a rapid and simple in vitro method to assess the responsiveness of a biopolymer matrix to enzymatic modification

1995 • 10 citations

A new rheometer with special features designed for bronchial mucus analysis in clinical practice

1992 • 8 citations

The role of rheological properties in mucociliary transport by frog palate ciliated model.

1994 • 7 citations

Magnetic Rheometry of Bronchial Mucus

1992 • 5 citations

The dependence on counter-cation of the degree of hydration of heparin

1990 • 4 citations

Drug-mucus actions and interactions.

1989 • 4 citations

A direct measuring capillary viscoelastimeter for mucus

1987 • 4 citations

The hydration of mucus in cystic fibrosis.

1994 • 1 citations

Deleted Work

1955 • 0 citations