Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Chronic Lymphocytic Leukemia

2005 • 1,679 citations

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

2007 • 1,306 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

2001 • 934 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations

2006 • 507 citations

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

1981 • 477 citations

Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia

2004 • 433 citations

Chronic lymphocytic leukemia: revelations from the B-cell receptor

2004 • 401 citations

B‐cell subsets and the mature ­preimmune repertoire. Marginal zone and B1 B cells as part of a “natural immune memory”

2000 • 380 citations

B Cell Chronic Lymphocytic Leukemia: Lessons Learned from Studies of the B Cell Antigen Receptor

2003 • 377 citations

B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

2002 • 358 citations

Apoptotic Cells with Oxidation-specific Epitopes Are Immunogenic and Proinflammatory

2004 • 336 citations

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity

2005 • 331 citations

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis

2007 • 328 citations

Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.

1989 • 290 citations

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

2004 • 280 citations

Residues that mediate DNA binding of autoimmune antibodies.

1993 • 268 citations

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

2008 • 264 citations

Autoreactive B Cells in the Marginal Zone that Express Dual Receptors

2002 • 260 citations

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

2004 • 258 citations

Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies

1990 • 222 citations

Nucleosomes Are Exposed at the Cell Surface in Apoptosis

2004 • 217 citations

All T15 Id-positive antibodies (but not the majority of V_HT15⁺ antibodies) are produced by peritoneal CD5⁺ B lymphocytes

1990 • 197 citations

Chronic lymphocytic leukemic (CLL) cells secrete multispecific autoantibodies

1988 • 179 citations

Oxidation‐specific epitopes are important targets of innate immunity

2008 • 170 citations

Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone

1997 • 167 citations

Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis

2005 • 160 citations

Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA

2008 • 158 citations

Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells

1999 • 121 citations

Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain.

1994 • 120 citations

The human fetal omentum: a site of B cell generation.

1992 • 120 citations

The Autoreactivity of Anti-Phosphorylcholine Antibodies for Atherosclerosis-Associated Neo-Antigens and Apoptotic Cells

2003 • 110 citations

Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia

1997 • 108 citations

Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia

2006 • 104 citations

Differential Epitope Positioning within the Germline Antibody Paratope Enhances Promiscuity in the Primary Immune Response

2006 • 104 citations

Autoimmunity and apoptosis.

1994 • 83 citations

IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics

2003 • 73 citations

Toll-like receptors and innate immune responses in systemic lupus erythematosus

2007 • 58 citations

Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients

2008 • 55 citations

Changes in vimentin in human macrophages during apoptosis induced by oxidised low density lipoprotein

2001 • 47 citations

Cleavage of Nonmuscle Myosin Heavy Chain-A during Apoptosis in Human Jurkat T Cells

2005 • 23 citations

B-Cell Chronic Lymphocytic Leukemia (B-CLL) Cells Express Antibodies Reactive with Antigenic Epitopes Expressed on the Surface of Common Bacteria.

2006 • 22 citations

Characterization of the nucleic acid binding region of the intermediate filament protein vimentin by fluorescence polarization.

1999 • 21 citations

Characterization of the Nucleic Acid Binding Region of the Intermediate Filament Protein Vimentin by Fluorescence Polarization

1999 • 21 citations

CD5⁺ B cells with the features of subepithelial B cells found in human tonsils

2007 • 20 citations

Chronic Lymphocytic Leukemia in the Elderly Population

1997 • 16 citations

Elucidating the Oncogenic Potential of NPMc+ In Vitro and In Vivo.

2006 • 7 citations