Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Department of Health, Education, and Welfare

1976 • 4,071 citations

Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion

1976 • 1,926 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

1981 • 477 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Affinity labeling of a phosphorylcholine binding mouse myeloma protein

1972 • 349 citations

Genetics of the Antibody Response to Dextran in Mice

1972 • 348 citations

Mouse myeloma proteins with antihapten antibody activity. Protein produced by plasma cell tumor MOPC-315

1968 • 339 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

1980 • 306 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

QUANTITATIVE INVESTIGATIONS OF IDIOTYPIC ANTIBODIES

1972 • 291 citations

Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segments

1980 • 272 citations

Antigen-Binding Myeloma Proteins of Mice

1978 • 272 citations

The Search for Antibodies with Molecular Uniformity

1970 • 258 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I<scp>G</scp>A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE

1970 • 248 citations

Antibody Diversity

1978 • 240 citations

IMMUNOLOGICAL RELATIONSHIPS AMONG THE MYELOMA PROTEINS

1955 • 218 citations

Three-Dimensional Structure of Immunoglobulins

1975 • 218 citations

The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution

1974 • 213 citations

ATTEMPTS TO LOCATE COMPLEMENTARITY‐DETERMINING RESIDUES IN THE VARIABLE POSITIONS OF LIGHT AND HEAVY CHAINS *

1971 • 212 citations

Rearrangement of genetic information may produce immunoglobulin diversity

1978 • 209 citations

Antibody activity of human myeloma globulins.

1973 • 201 citations

Somatic mutation of immunoglobulin light-chain variable-region genes

1981 • 184 citations

Specificity for phosphorylchloine of six murine myeloma proteins reactive with Pneumococcus C polysaccharide and β-lipoprotein

1971 • 179 citations

Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice

1972 • 172 citations

Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae

1981 • 170 citations

Binding properties of immunoglobulin combining sites specific for terminal or nonterminal antigenic determinants in dextran.

1975 • 168 citations

The role of gene deletion in the immunoglobulin heavy chain switch

1980 • 164 citations

Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes

1980 • 159 citations

Contemporary topics in molecular immunology

1974 • 158 citations

The Upper Limit for the Size of the Human Antidextran Combining Site

1960 • 153 citations

Immunochemical Analysis of the Cross-Reacting Idiotypes of Mouse Myeloma Proteins with Anti-Dextran Activity and Normal Anti-Dextran Antibody

1973 • 141 citations

The joining of V and J gene segments creates antibody diversity

1980 • 137 citations

Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.

1980 • 129 citations

Structural basis for the specificity of phosphorylcholine-binding immunoglobulins

1976 • 125 citations

Heterogeneity in Extent of the Combining Regions of Human Antidextran

1956 • 121 citations

Immunochemical studies of the reaction between a mouse myeloma macroglobulin and dextrans

1970 • 116 citations

Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran.

1980 • 115 citations

Kinetic mapping of the antibody combining site by chemical relaxation spectrometry

1974 • 113 citations

Single amino acid substitution altering antigen-binding specificity.

1982 • 112 citations

Three IgA Myeloma Immunoglobulins from the BALB/c Mouse: Precipitation with Pneumococcal C Polysaccharide

1968 • 111 citations

Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.

1981 • 109 citations

Ordering of mouse immunoglobulin heavy chain genes by molecular cloning

1981 • 101 citations

Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class.

1980 • 101 citations

Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome

1980 • 98 citations

DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats.

1978 • 98 citations

Multiple individual and cross-specific indiotypes on 13 levan-binding myeloma proteins of BALB/c mice.

1975 • 97 citations

Localization of affinity-labeled residues on the heavy and light chain of two myeloma proteins with anti-hapten activity

1972 • 95 citations

Structure of an antibody combining site by magnetic resonance

1977 • 89 citations

Immunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine

1974 • 89 citations

Natural History of the Myeloma

1967 • 88 citations

Model-building Studies of Antigen-binding Sites: The Hapten-binding Site of MOPC-315

1977 • 86 citations

Antigen-binding mutants of mouse myeloma cells.

1977 • 82 citations

Immunochemical studies on mouse myeloma proteins with specificity for dextran or for levan

1972 • 81 citations

Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Sequence and position of a labeled tryptic peptide

1970 • 78 citations

IMMUNOCHEMICAL STUDIES ON MOUSE MYELOMA PROTEINS REACTIVE WITH DEXTRANS OR WITH FRUCTOSANS AND ON HUMAN ANTILEVANS

1974 • 78 citations

Somatic mutation in a cultured mouse myeloma cell affects antigen binding.

1982 • 76 citations

Mouse Lambda-Chain Sequences

1973 • 75 citations

Binding properties of a mouse immunoglobulin M myeloma protein with carbohydrate specificity

1971 • 74 citations

Structural studies on induced antibodies with defined idiotypic specificities. IX. Framework differences in the heavy- and light-chain-variable regions of monoclonal anti-p-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.

1980 • 73 citations

Size and heterogeneity of the combining sites on an antibody molecule

1957 • 71 citations

Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions

1979 • 71 citations

Uniformity in the clonal repertoire for the immune response to phosphorylcholine in mice

1976 • 69 citations

Nucleotide sequence of immunoglobulin heavy chain joining segments between translocated VH and mu constant regions genes.

1980 • 69 citations

Structural diversity among anti-p-azophenylarsonate monoclonal antibodies from A/J mice: Comparison of Id− and Id+ sequences

1981 • 65 citations

Affinity labeling and cross-linking of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenol activity

1971 • 64 citations

Dynamics of hapten-antibody interaction. Studies on a myeloma protein with anti-2, 4-dinitrophenyl specificity

1972 • 63 citations

Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families.

1983 • 63 citations

Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.

1976 • 61 citations

Anti-phosphocholine hybridoma antibodies. I. Direct evidence for three distinct families of antibodies in the murine response

1981 • 60 citations

Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein

1974 • 60 citations

Affinity Labeling of the Active Sites of Antibodies to the 2,4-Dinitrophenyl Hapten^*

1963 • 60 citations

Genetics of Susceptibility to Plasmacytoma Induction. I. BALB/cAnN (C), C57BL/6N (B6), C57BL/Ka (BK), (C × B6)F 1 , (C × BK) F 1 , and C × B Recombinant-Inbred Strains

1975 • 59 citations

A hypothetical space-filling model of the V-regions of the galactan-binding myeloma immunoglobulin J539☆

1981 • 58 citations

The Structure and Genetics of Mouse Immunoglobulins: An Analysis of NZB Myeloma Proteins and Sets of BALB/c Myeloma Proteins Binding Particular Haptens

1977 • 58 citations

Multiple Myeloma and Related Disorders.

1974 • 56 citations

Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype.

1981 • 56 citations

Structural requirements for the binding of derivatives of D-galactose to two homogeneous murine immunoglobulins

1974 • 54 citations

Homogeneous Antibodies: Induction and Value as Probe for the Antibody Problem

1974 • 51 citations

Polymorphism in immunoglobulin heavy chains suggesting gene conversion.

1982 • 50 citations

Progress in Immunology: First International Congress of Immunology

2014 • 47 citations

SIX BALB/c IgA MYELOMA PROTEINS THAT BIND ß-(1 → 6)-<scp>D</scp>-GALACTAN

1973 • 47 citations

kappa Chain joining segments and structural diversity of antibody combining sites.

1980 • 46 citations

Specificity and structure of the myeloma protein produced by mouse plasmacytoma MOPC-460

1971 • 46 citations

THE PARTICIPATION OF A AND B POLYPEPTIDE CHAINS IN THE ACTIVE SITES OF ANTIBODY MOLECULES

1964 • 45 citations

Immunochemical studies on a mouse myeloma protein with specificity for certain β-linked terminal residues of N-acetyl-d-glucosamine

1970 • 45 citations

Nucleic acid and protein sequences of phosphocholine-binding light chains.

1981 • 45 citations

The combining site of the dinitrophenyl-binding immunoglobulin A myeloma protein MOPC 315

1977 • 43 citations

Crystal structure of galactan-binding mouse immunoglobulin J539 Fab at 4.5-A resolution.

1979 • 42 citations

Attempts to locate residues in complementarity-determining regions of antibody combining sites that make contact with antigen.

1976 • 42 citations

Structural Studies on the Combining Site of the Myeloma Protein MOPC 315

1975 • 40 citations

THE STRANGE CROSS-REACTION OF MENADIONE (VITAMIN K3) AND 2,4-DINITROPHENYL LIGANDS WITH A MYELOMA PROTEIN AND SOME CONVENTIONAL ANTIBODIES

1974 • 38 citations

Subunit interactions in mouse myeloma proteins with anti-galactan activity.

1976 • 38 citations

Kappa chain structure from a crystallized murine Fab′: Role of joining segment in hapten binding

1981 • 38 citations

On the location and structure of the active sites of antibody molecules.

1968 • 36 citations

Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains.

1976 • 35 citations

Affinity Labeling of the Heavy and Light Chains of a Myeloma Protein with Anti-2,4-Dinitrophenyl Activity

1970 • 35 citations

Affinity Labeling of the Active Sites of Rabbit Anti-2,4-dinitrophenyl Antibodies with m-Nitrobenzenediazonium Fluoroborate^*

1967 • 34 citations

kappa-Chain restriction in anti-galactan antibodies.

1982 • 33 citations

The affinity of a linear, α-D-(1→6)-linked D-glucopyranan (dextran) for homogeneous immunoglobulin A W3129

1979 • 33 citations

Affinity Site Labeling of a Mouse Myeloma Protein Which Binds Dinitrophenyl Ligands

1968 • 30 citations

The gross architecture of an antibody-combining site as determined by spin-label mapping

1977 • 30 citations

Idiotypes of inulin-binding myeloma proteins localized to variable region light and heavy chains: genetic significance.

1977 • 29 citations

Sequence variation among heavy chains from inulin-binding myeloma proteins

1978 • 28 citations

Hapten Binding Studies on Mouse IgA Myeloma Proteins with Antibody Activity

1971 • 27 citations

Uniformity in a Clonal Repertoire: A Case for a Germ-line Basis of Antibody Diversity

1977 • 26 citations

The complete V domain amino acid sequences of two myeloma inulin-binding proteins.

1982 • 26 citations

Serological distinciton of heavy chain variable regions (VH subgroups) of mouse immunoglobulins. I. Common VH determinants on the heavy chains of mouse myeloma proteins having different binding sites.

1977 • 24 citations

The structural basis of a hapten-inhibitable kappa-chain idiotype.

1979 • 24 citations

κ Chain variable region from M167, a phosphorylcholine binding myeloma protein

1978 • 22 citations

Phosphorylcholine‐binding hybridoma proteins of normal and idiotypically suppressed BALB/c mice. II. Variable region N‐terminal amino acid sequences

1980 • 22 citations

Allelic forms of anti-phosphorylcholine antibodies.

1981 • 21 citations

The cross-reactive idiotype of anti-4-azobenzenearsonate hybridoma-derived antibodies in A/J mice constitutes multiple heavy chains.

1980 • 21 citations

The Structural Basis of a Hapten-Inhibitable κ-Chain Idiotype

1979 • 19 citations

The binding of phosporylcholine-containing antigens from Streptococcus pneumoniae to myeloma immunoglobulins M-603 and H-8

1977 • 19 citations

Immunochemical studies on dextran-specific and levan-specific myeloma proteins from nzb mice

1978 • 19 citations

Allelic forms of the immunoglobulin heavy chain variable region.

1980 • 16 citations

The interaction of two polysaccharides containing β1,6-linked galactopyranosyl residues with two monoclonal antigalactan immunoglobulin Fab' fragments

1981 • 15 citations

The Presence of Arginyl Residues and Carboxylate Groups in the Phosphorylcholine-Binding Site of Mouse Myeloma Protein, HOPC 8

1974 • 15 citations

Specificity of interactions of hapten side chains with the combining site of the myeloma protein MOPC 315

1977 • 14 citations

Correction

1977 • 13 citations

Structural Evidence for a Polymorphic or Allelic form of the Heavy Chain Variable Region

1979 • 10 citations

Comparative Studies of Antibody Active Sites

1967 • 9 citations

Immunoglobulin heavy chains from anti-inulin myeloma proteins: evidence for a new heavy chain joining segment.

1981 • 6 citations