Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new method for sequencing DNA.

1977 • 7,941 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels

1977 • 1,607 citations

The use of thin acrylamide gels for DNA sequencing

1978 • 1,449 citations

Enhanced autoradiographic detection of ³²P and ¹²⁵I using intensifying screens and hypersensitized film

1977 • 947 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

A physical map of the DNA regions flanking the rabbit β-globin gene

1977 • 654 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Mouse myelomas and lymphomas in culture

1970 • 559 citations

Immunoglobulin-producing tumors and myeloma proteins of mice.

1972 • 518 citations

Biological Activities of Immunoglobulins of Different Classes and Subclasses

1974 • 501 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUES

1965 • 444 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

The molecular basis of antibody formation: a paradox.

1965 • 394 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS

1970 • 284 citations

The arrangement and rearrangement of antibody genes

1978 • 277 citations

THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS

1972 • 272 citations

Antigen-Binding Myeloma Proteins of Mice

1978 • 272 citations

Light Chain Evolution

1967 • 263 citations

THE GENETIC CONTROL OF IMMUNOGLOBULIN SYNTHESIS

1972 • 249 citations

COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I<scp>G</scp>A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE

1970 • 248 citations

Chromatid structure: relationship between DNA content and nucleotide sequence diversity

1971 • 241 citations

Antibody Diversity

1978 • 240 citations

Suppression of Immunoglobulin G Synthesis as a Result of Antibody-Mediated Suppression of Immunoglobulin M Synthesis in Chickens

1970 • 235 citations

RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO α-, γ-, AND µ- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS A<scp>A</scp>1 AND A<scp>A</scp>2

1966 • 212 citations

Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey That Suggests a Model for the Generation of Immunoglobulin Isotype Diversity

1978 • 211 citations

Rearrangement of genetic information may produce immunoglobulin diversity

1978 • 209 citations

Similar Idiotypic Specificity for the Membrane IgD and IgM of Human B Lymphocytes

1975 • 179 citations

Somatic Translocation of Antibody Genes

1970 • 178 citations

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

1975 • 139 citations

Amino acid sequence of a mouse immunoglobulin mu chain.

1979 • 134 citations

Somatic Changes in the Content and Context of Immunoglobulin Genes

1977 • 132 citations

GENETICS OF ANTIBODIES

1968 • 124 citations

Genetic control of antibody specificity in the mouse

1975 • 116 citations

Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.

1976 • 108 citations

Variable region genes for the immunoglobulin framework are assembled from small segments of DNA—A hypothesis

1978 • 107 citations

A very large repeating unit of mouse DNA containing the 18S, 28S and 5.8S rRNA genes

1977 • 99 citations

Incidence of cells simultaneously secreting IgM and IgG antibody to sheep erythrocytes

1971 • 90 citations

Natural History of the Myeloma

1967 • 88 citations

Expression of phosphorylcholine-specific B cells during murine development

1977 • 85 citations

Late acquisition of a germ line antibody specificity

1976 • 81 citations

Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA

1978 • 71 citations

Genetics, Cellular Expression and Function of IgD and IgM Receptors

1977 • 69 citations

Immunoglobulin Allotypes

1973 • 69 citations

mu-Chains from a nonsecretor B cell line differ from secreted mu-chains at the C-terminal end.

1978 • 63 citations

Structure of Immunoglobulins

1973 • 61 citations

Intervening sequences divide the gene for the constant region of mouse immunoglobulin mu chains into segments, each encoding a domain.

1980 • 59 citations

The Structure and Genetics of Mouse Immunoglobulins: An Analysis of NZB Myeloma Proteins and Sets of BALB/c Myeloma Proteins Binding Particular Haptens

1977 • 58 citations

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome.

1979 • 54 citations

Mouse Immunoglobulin Heavy Chains Are Coded by Multiple Germ Line Variable Region Genes

1974 • 53 citations

Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins.

1976 • 43 citations

Surface Markers and Functional Relationships of Cells Involved in Murine B-lymphocyte Differentiation

1977 • 43 citations

Immunoglobulin structure and genetics. Identity between variable regions of a mu and a gamma2 chain.

1977 • 41 citations

Genetics of the immunoglobulin variable region

1974 • 39 citations

Nuclear Transcripts of Mouse Heavy Chain Immunoglobulin Genes Contain Only the Expressed Class of C-Region Sequences

1979 • 37 citations

Organization of Immunoglobulin Genes

1978 • 37 citations

Structural differences between macroglobulins belonging to two serologically distinguishable subclasses

1968 • 32 citations

The Binding of Murine IgM to Staphylococcal A Protein

1978 • 32 citations

Molecular cloning of mouse immunoglobulin heavy chain messenger ribonucleic acids coding for .mu., .alpha., .gamma.1, .gamma.2a, and .gamma.3 chains

1980 • 30 citations

Cloning of immunoglobulin kappa light chain genes from mouse liver and myeloma MOPC 173

1979 • 29 citations

The generation of antibody diversity, a new look

1977 • 28 citations

Chromosomal locations of mouse immunoglobulin genes.

1978 • 26 citations

Clonal evolution of myeloma cells leads to quantitative changes in immunoglobulin secretion and surface antigen expression.

1979 • 26 citations

Chromosomal Alteration and Development of Tumors. XIX. Chromosome Constitution of Tumor Cells in 16 Plasma Cell Neoplasms of BALB/c Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1968 • 20 citations

Immunoglobulin µ and γ heavy chain classes are not determined by class-specific RNA-splicing enzymes

1978 • 18 citations

Amino acid sequence of the first 217 residues of a mouse heavy chain (MOPC 47A) with a domain deletion.

1977 • 15 citations

Quantitation of Antibody Genes by Molecular Hybridization

1977 • 14 citations

The Significance of Hybridization Kinetic Experiments for Theories of Antibody Diversity

1977 • 10 citations

Organization of immunoglobulin genes

1978 • 5 citations

Mechanism of ploidy shift from diploidy to tetraploidy in MSPC-1 mouse myeloma

1978 • 3 citations

The multicellular (as opposed to the monoclonal) origin of the murine myeloma cell

1975 • 2 citations