Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Current protocols in molecular biology

1988 • 2,473 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Octamania: The POU factors in murine development

1991 • 373 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif

1988 • 304 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors

1992 • 272 citations

The DNA binding specificity of the bipartite POU domain and its subdomains.

1992 • 268 citations

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

1990 • 248 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

1988 • 234 citations

The B-cell antigen receptor complex

1991 • 213 citations

Two regulatory elements for immunoglobulin kappa light chain gene expression.

1984 • 197 citations

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.

1988 • 197 citations

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.

1988 • 174 citations

The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies.

1981 • 158 citations

The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter.

1987 • 144 citations

An immunoglobulin promoter displays cell-type specificity independently of the enhancer

1985 • 144 citations

Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro.

1988 • 132 citations

How do different transcription factors binding the same DNA sequence sort out their jobs?

1989 • 126 citations

Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene

1990 • 125 citations

Cell-type preference of immunoglobulin kappa and lambda gene promoters.

1985 • 118 citations

Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters.

1990 • 117 citations

Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities.

1991 • 99 citations

Common mechanisms of promoter recognition by RNA polymerases II and III

1989 • 92 citations

Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration

1991 • 81 citations

Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene.

1989 • 77 citations

Contribution of Promoter to Tissue-Specific Expression of the Mouse Immunoglobulin Kappa Gene

1985 • 76 citations

BLyF, a Novel Cell-Type- and Stage-Specific Regulator of the B-Lymphocyte Gene mb-1

1992 • 67 citations

Oct2 Transactivation from a Remote Enhancer Position Requires a B-Cell-Restricted Activity

1992 • 63 citations

Extinction of an immunoglobulin κ promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression

1990 • 61 citations

The regulation of growth and differentiation of a murine B cell lymphoma. I. Lipopolysaccharide-induced differentiation.

1981 • 57 citations

Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor.

1990 • 49 citations

Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point.

1990 • 48 citations

Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation.

1991 • 44 citations

The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.

1990 • 44 citations

Activation of Octamer-Containing Promoters by Either Octamer-Binding Transcription Factor 1 (OTF-1) or OTF-2 and Requirement of an Additional B-Cell-Specific Component for Optimal Transcription of Immunoglobulin Promoters

1990 • 41 citations

Cell‐Type Specific Regulation of a K Immunoglobulin Gene by Promoter and Enhancer Elements

1986 • 21 citations

The Ubiquitous Octamer-Binding Protein(s) Is Sufficient for Transcription of Immunoglobulin Genes

1990 • 18 citations

Regulation and a Possible Stage-Specific Function of Oct-2 during Pre-B-Cell Differentiation

1991 • 17 citations

Antigen Receptor-Induced Cell Cycle Arrest in WEHI-231 B Lymphoma Cells Depends on the Duration of Signaling before the G₁ Phase Restriction Point

1990 • 10 citations