Essential Role for the Legionella pneumophila Rep Helicase Homologue in Intracellular Infection of Mammalian Cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

1995 • 5,571 citations

Legionnaires' Disease

1977 • 1,199 citations

MECHANISMS OF HELICASE-CATALYZED DNA UNWINDING

1996 • 740 citations

Conjugative Transfer by the Virulence System of Legionella pneumophila

1998 • 709 citations

The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.

1983 • 704 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes.

1983 • 644 citations

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila

1993 • 633 citations

Association of Legionella pneumophila with the macrophage endoplasmic reticulum

1995 • 556 citations

The molecular ecology of legionellae

1996 • 539 citations

Major Domain Swiveling Revealed by the Crystal Structures of Complexes of E. coli Rep Helicase Bound to Single-Stranded DNA and ADP

1997 • 490 citations

Classification of the Legionnaires' Disease Bacterium: Legionella pneumophila, genus novum, species nova, of the Family Legionellaceae, familia nova

1979 • 393 citations

Expression of Legionella pneumophila Virulence Traits in Response to Growth Conditions

1998 • 361 citations

Identification of Legionella pneumophila genes required for growth within and killing of human macrophages

1993 • 357 citations

Legionella pneumophila Utilizes the Same Genes To Multiply within Acanthamoeba castellanii and Human Macrophages

1999 • 299 citations

Invasion of Protozoa by Legionella pneumophila and Its Role in Bacterial Ecology and Pathogenesis

1998 • 245 citations

The modulation of host cell apoptosis by intracellular bacterial pathogens

2000 • 237 citations

Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa

1997 • 236 citations

Evidence for pore‐forming ability by Legionella pneumophila

1998 • 227 citations

THYMINE METABOLISM AND THYMINELESS DEATH IN PROKARYOTES AND EUKARYOTES

1998 • 227 citations

From protozoa to mammalian cells: a new paradigm in the life cycle of intracellular bacterial pathogens

2000 • 221 citations

Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion

1996 • 205 citations

The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum

1996 • 200 citations

The rep mutation

1975 • 197 citations

Natural Competence for DNA Transformation by Legionella pneumophila and Its Association with Expression of Type IV Pili

1999 • 187 citations

Legionnaires' Disease

1993 • 181 citations

Phenotypic modulation by Legionella pneumophila upon infection of macrophages

1993 • 170 citations

Escherichia coli DNA helicases: mechanisms of DNA unwinding

1992 • 166 citations

Apoptosis in Macrophages and Alveolar Epithelial Cells during Early Stages of Infection byLegionella pneumophilaand Its Role in Cytopathogenicity

1999 • 132 citations

Temporal Pore Formation-Mediated Egress from Macrophages and Alveolar Epithelial Cells byLegionella pneumophila

2000 • 126 citations

Identification of Legionella pneumophila mutants that have aberrant intracellular fates

1996 • 122 citations

The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila

1999 • 119 citations

Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection

1996 • 116 citations

Identification and Temperature Regulation of Legionella pneumophila Genes Involved in Type IV Pilus Biogenesis and Type II Protein Secretion

1998 • 111 citations

The mechanism of killing and exiting the protozoan host Acanthamoeba polyphaga by Legionella pneumophila

2000 • 110 citations

TheLegionella pneumophila icmGCDJBFGenes Are Required for Killing of Human Macrophages

1998 • 109 citations

Activation of Caspase 3 duringLegionella pneumophila-Induced Apoptosis

1999 • 109 citations

Hijacking of apoptotic pathwaysby bacterial pathogens

2000 • 101 citations

How is the intracellular fate of the Legionella pneumophila phagosome determined?

1998 • 101 citations

Identification of a Gal/GalNAc Lectin in the Protozoan Hartmannella vermiformis as a Potential Receptor for Attachment and Invasion by the Legionnaires' Disease Bacterium

1997 • 101 citations

Identification of Macrophage-Specific Infectivity Loci ( mil ) of Legionella pneumophila That Are Not Required for Infectivity of Protozoa

1998 • 91 citations

Transcriptional regulation of the macrophage‐induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant

1997 • 90 citations

Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence

1996 • 88 citations

Fatal attraction of mammalian cells to Legionella pneumophila

1998 • 84 citations

Heterogeneity in the Attachment and Uptake Mechanisms of the Legionnaires’ Disease Bacterium, Legionella pneumophila , by Protozoan Hosts

1998 • 78 citations

Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes

1988 • 75 citations

Community Outbreak of Legionnaires' Disease: An Investigation Confirming the Potential for Cooling Towers to Transmit Legionella Species

1996 • 75 citations

Legionella pneumophila Replicates within Rat Alveolar Epithelial Cells

1993 • 73 citations

Analysis of the Intracellular Fate of Legionella pneumophila Mutants^a

1996 • 69 citations

Induced Expression of the Legionella pneumophila Gene Encoding a 20-Kilodalton Protein during Intracellular Infection

1998 • 65 citations

The rep mutation

1972 • 64 citations

Cloning and molecular characterization of a Legionella pneumophila gene induced by intracellular infection and by various in vitro stress conditions

1994 • 62 citations

Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cells

1999 • 60 citations

Different fates ofLegionella pneumophila pmiandmilmutants within macrophages and alveolar epithelial cells

1998 • 60 citations

Identification of the Aspartate-β-Semialdehyde Dehydrogenase Gene of Legionella pneumophila and Characterization of a Null Mutant

1998 • 59 citations

Escherichia coli repgene: sequence of the gene, the encoded helicase, and its homology withuvrD^*

1987 • 55 citations

Legionnaires' disease: the pore macrophage and the legion of terror within

1998 • 51 citations

Identification of Putative Cytoskeletal Protein Homologues in the Protozoan Host Hartmannella vermiformis as Substrates for Induced Tyrosine Phosphatase Activity upon Attachment to the Legionnaires' Disease Bacterium, Legionella pneumophila

1998 • 42 citations

The Legionella pneumophila prp locus; required during infection of macrophages and amoebae

1999 • 37 citations

Entamoeba histolytica:Involvement of pp125FAKin Collagen-Induced Signal Transduction

1996 • 35 citations

Characterization of a Macrophage-Specific Infectivity Locus ( milA ) of Legionella pneumophila

2000 • 31 citations

Invasion of mammalian and protozoan cells by Legionella pneumophila

1998 • 30 citations

Phenotypic modulation by intracellular bacterial pathogens

1999 • 23 citations

Probing the microenvironment of intracellular bacterial pathogens

1999 • 21 citations

Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity

1997 • 14 citations

Prevalence of Pneumonia due to <i>Legionella pneumophila</i> and <i>Mycoplasma pneumoniae</i> in a Population Admitted to a Department of Internal Medicine

1995 • 9 citations