Beyond the Glial Scar

Degeneration and Regeneration of the Nervous System.

1929 • 2,924 citations

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats

1981 • 1,679 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

1990 • 1,232 citations

Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study

1997 • 1,201 citations

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

1994 • 1,123 citations

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury

1997 • 1,089 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Axons from CNS neurones regenerate into PNS grafts

1980 • 928 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.

1988 • 876 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro

1990 • 775 citations

Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function

1996 • 764 citations

Regeneration of adult axons in white matter tracts of the central nervous system

1997 • 747 citations

Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors

1995 • 723 citations

Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data

1992 • 716 citations

Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes

1985 • 714 citations

The origin and nature of ramified and amoeboid microglia: A historical review and current concepts

1993 • 682 citations

Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function

1996 • 653 citations

Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

1997 • 620 citations

The outgrowth of the nerve fiber as a mode of protoplasmic movement

1910 • 615 citations

Intraspinal Sprouting of Dorsal Root Axons

1958 • 609 citations

The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration.

1987 • 596 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Quantitative aspects of reactive gliosis: A review

1992 • 548 citations

Inhibitors of Neurite Growth

1993 • 545 citations

Glial cells and the central myelin sheath.

1968 • 530 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Astroglia in CNS injury

1991 • 496 citations

Astrocyte‐specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein

1974 • 493 citations

Injury-Induced Proteoglycans Inhibit the Potential for Laminin-Mediated Axon Growth on Astrocytic Scars

1995 • 487 citations

THE ASTROGLIAL RESPONSE TO STABBING. IMMUNOFLUORESCENCE STUDIES WITH ANTIBODIES TO ASTROCYTE‐SPECIFIC PROTEIN (GFA) IN MAMMALIAN AND SUBMAMMALIAN VERTEBRATES

1976 • 473 citations

Role of glial cells in the regulation of the brain ion microenvironment

1989 • 448 citations

The outgrowth of the nerve fiber as a mode of protoplasmic movement

1959 • 443 citations

Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan

1994 • 415 citations

Fibrillary astrocytes proliferate in response to brain injury

1979 • 399 citations

Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury

1994 • 395 citations

Macrophages and inflammation in the central nervous system

1993 • 390 citations

Laminin is produced by early rat astrocytes in primary culture.

1983 • 389 citations

Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions

1998 • 386 citations

Observations on the astrocyte response to a cerebral stab wound in adult rats

1985 • 354 citations

Laminin is induced in astrocytes of adult brain by injury.

1984 • 315 citations

Regeneration in the Mammalian Peripheral Nervous System

1956 • 312 citations

Delayed Macrophage Responses and Myelin Clearance during Wallerian Degeneration in the Central Nervous System: The Dorsal Radiculotomy Model

1994 • 303 citations

Reactive glia as rivals in regulating neuronal survival

1993 • 299 citations

Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth

1990 • 299 citations

Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury.

1992 • 297 citations

Fibroblasts Genetically Modified to Produce Nerve Growth Factor Induce Robust Neuritic Ingrowth after Grafting to the Spinal Cord

1994 • 287 citations

Deposition of Scar Tissue in the Central Nervous System

1983 • 285 citations

Oligodendrocytes arrest neurite growth by contact inhibition

1990 • 285 citations

Impaired neuroglial activation in interleukin-6 deficient mice

1997 • 284 citations

Pathological findings in acute experimental spinal cord trauma

1971 • 281 citations

Transplantation of activated macrophages overcomes central nervous system regrowth failure

1996 • 281 citations

Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats

1988 • 279 citations

Functional Recovery and Enhanced Corticofugal Plasticity after Unilateral Pyramidal Tract Lesion and Blockade of Myelin-Associated Neurite Growth Inhibitors in Adult Rats

1998 • 278 citations

Activated Macrophages and the Blood–Brain Barrier: Inflammation after CNS Injury Leads to Increases in Putative Inhibitory Molecules

1997 • 274 citations

Nervous tissue proteoglycans

1993 • 269 citations

Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuronal Properties in the Mammalian Brain

1990 • 269 citations

Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules.

1993 • 268 citations

A chondroitin sulfate proteoglycan may influence the direction of retinal ganglion cell outgrowth

1991 • 264 citations

Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve

1996 • 263 citations

Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

1993 • 259 citations

Putative Inhibitory Extracellular Matrix Molecules at the Dorsal Root Entry Zone of the Spinal Cord during Development and after Root and Sciatic Nerve Lesions

1993 • 252 citations

Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS

1995 • 251 citations

Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth

1997 • 251 citations

Nerve Growth Factor Delivery by Gene Transfer Induces Differential Outgrowth of Sensory, Motor, and Noradrenergic Neurites after Adult Spinal Cord Injury

1996 • 250 citations

Reactive Gliosis as a Consequence of Interleukin-6 Expression in the Brain: Studies in Transgenic Mice

1994 • 242 citations

The reaction of embryonic cells to solid structures

1914 • 238 citations

Preferential outgrowth of central nervous system neurites on astrocytes and Schwann cells as compared with nonglial cells in vitro.

1985 • 232 citations

Glial cell extracellular matrix: boundaries for axon growth in development and regeneration

1997 • 232 citations

Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brain

1986 • 227 citations

Chapter 22 Response of rubrospinal and corticospinal neurons to injury and neurotrophins

1994 • 227 citations

Intrinsic changes in developing retinal neurons result in regenerative failure of their axons.

1995 • 219 citations

Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury

1993 • 218 citations

Is astrocyte laminin involved in axon guidance in the mammalian CNS?

1988 • 215 citations

Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth

1989 • 214 citations

Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord

1994 • 213 citations

Is reactive gliosis a property of a distinct subpopulation of astrocytes?

1986 • 206 citations

Effects of pro-inflammatory cytokines in experimental spinal cord injury

1997 • 201 citations

Smooth muscle cell expression of extracellular matrix genes after arterial injury.

1994 • 200 citations

An inhibitor of neurite outgrowth produced by astrocytes

1994 • 200 citations

Regeneration of Axons in the Vertebrate Central Nervous System

1956 • 200 citations

The Impact of Microglia-Derived Cytokines upon Gliosis in the CNS

1994 • 195 citations

Immunocytochemical demonstration of early appearing astroglial structures that form boundaries and pathways along axon tracts in the fetal brain

1993 • 194 citations

Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord.

1990 • 193 citations

Surveillance, Intervention and Cytotoxicity: Is There a Protective Role of Microglia?

1994 • 185 citations

Axonal regeneration across transected mammalian spinal cords: An electron microscopic study of delayed microsurgical nerve grafting☆

1977 • 183 citations

Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor

1991 • 183 citations

Amyloid β protein (Aβ) removal by neuroglial cells in culture

1995 • 182 citations

Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture

1994 • 181 citations

Proliferation of mature oligodendrocytes after trauma to the central nervous system

1984 • 179 citations

Effects of silica on the outcome from experimental spinal cord injury: Implication of macrophages in secondary tissue damage

1994 • 175 citations

Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite outgrowth from PC12D cells.

1991 • 171 citations

A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury.

1995 • 168 citations

Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord.

1992 • 166 citations

Quantitative studies on proliferative changes of reactive astrocytes in mouse cerebral cortex

1988 • 163 citations

Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats

1992 • 162 citations

Astrocytes secrete basal lamina after hemisection of rat spinal cord

1985 • 160 citations

Growth of regenerating goldfish axons is inhibited by rat oligodendrocytes and CNS myelin but not but not by goldfish optic nerve tract oligodendrocytelike cells and fish CNS myelin

1991 • 157 citations

Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite outgrowth from PC12D cells

1991 • 155 citations

Identification of a developmentally regulated keratan sulfate proteoglycan that inhibits cell adhesion and neurite outgrowth

1991 • 154 citations

La influencia del neurotropismo en la regeneracion de los centros nerviosos

1911 • 154 citations

Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts

1997 • 154 citations

Sprouts from Cut Corticospinal Axons Persist in the Presence of Astrocytic Scarring in Long-Term Lesions of the Adult Rat Spinal Cord

1995 • 154 citations

Neuronophagia by Leukocytes in Experimental Spinal Cord Injury

1983 • 153 citations

Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds

1996 • 153 citations

Astrogliosis in the Neonatal and Adult Murine Brain Post-Trauma: Elevation of Inflammatory Cytokines and the Lack of Requirement for Endogenous Interferon-γ

1997 • 151 citations

Glial fibrillary acidic protein in cryogenic lesions of the rat brain

1981 • 151 citations

Correlation between growth form and movement and their dependence on neuronal age

1984 • 150 citations

Cross talk between the immune system and the nervous system in response to injury: implications for regeneration

1994 • 149 citations

β-Amyloid of Alzheimer's Disease Induces Reactive Gliosis That Inhibits Axonal Outgrowth

1993 • 148 citations

Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin

1994 • 148 citations

Experimental Analysis of Progressive Necrosis after Spinal Cord Trauma in the Rat: Etiological Role of the Inflammatory Response

1997 • 146 citations

Inhibition of formation of a glial barrier as a means of permitting a peripheral nerve to grow into the brain

1952 • 144 citations

Regeneration in the spinal cord of the cat and dog

1950 • 143 citations

Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation.

1996 • 143 citations

Truncated trkB Receptors on Nonneuronal Cells Inhibit BDNF-Induced Neurite Outgrowthin Vitro

1997 • 142 citations

Trying to understand axonal regeneration in the CNS of fish

1992 • 139 citations

Purification, characterization and developmental expression of a brain-specific chondroitin sulfate proteoglycan, 6B4 proteoglycan/phosphacan

1995 • 134 citations

Inhibitors and Promoters of Thalamic Neuron Adhesion and Outgrowth in Embryonic Neocortex: Functional Association with Chondroitin Sulfate

1996 • 134 citations

Oligodendrocytes repel axons and cause axonal growth cone collapse

1989 • 128 citations

Regeneration of Cut Adult Axons Fails Even in the Presence of Continuous Aligned Glial Pathways

1996 • 128 citations

The Biology of the Oligodendrocyte

1984 • 127 citations

Regenerating axons form nerve terminals at astrocytes

1985 • 124 citations

Astroglial reaction in the gray matter of lumbar segments after midthoracic transection of the adult rat spinal cord

1981 • 119 citations

Long axon growth from embryonic neurons transplanted into myelinated tracts of the adult rat spinal cord

1993 • 116 citations

Regional Heterogeneity in the Response of Astrocytes following Traumatic Brain Injury in the Adult Rat

1996 • 116 citations

Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury.

1994 • 115 citations

A POTENT INHIBITOR OF NEURITE OUTGROWTH THAT PREDOMINATES IN THE EXTRACELLULAR MATRIX OF REACTIVE ASTROCYTES

1996 • 115 citations

Soluble Myelin-Associated Glycoprotein (MAG) Foundin VivoInhibits Axonal Regeneration

1997 • 114 citations

6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons

1996 • 114 citations

Focal brain injury and upregulation of a developmentally regulated extracellular matrix protein

1995 • 114 citations

Core Protein of Chondroitin Sulfate Proteoglycan Promotes Neurite Outgrowth from Cultured Neocortical Neurons

1991 • 112 citations

Astrocyte-polymer implants promote regeneration of dorsal root fibers into the adult mammalian spinal cord

1990 • 112 citations

Differences between adult and neonatal rats in their astroglial response to spinal injury

1984 • 110 citations

CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system

1995 • 110 citations

Reaction of oligodendrocytes and astrocytes to trauma and implantation. A combined autoradiographic and immunohistochemical study.

1985 • 110 citations

Regeneration of severed nerve fibers in the spinal cord of the adult cat

1954 • 109 citations

A chronicle of microglial ontogeny

1993 • 108 citations

Spinal Cord Injury in the Rat: Treatment with Bacterial Lipopolysaccharide and Indomethacin Enhances Cellular Repair and Locomotor Function

1994 • 108 citations

Ciliary Neurotrophic Factor Activates JAK/Stat Signal Transduction Cascade and Induces Transcriptional Expression of Glial Fibrillary Acidic Protein in Glial Cells

1997 • 106 citations

The effects of a lesion or a peripheral nerve graft on GAP-43 upregulation in the adult rat brain: an in situ hybridization and immunocytochemical study

1995 • 104 citations

Extensive regeneration in vitro by early embryonic neurons on immature and adult CNS tissue

1995 • 103 citations

The complexity in regulating the expression of tenascins

1995 • 102 citations

Involvement of a chondroitin sulfate proteoglycan in the avoidance of chick epidermis by dorsal root ganglia fibers: A study using β-d-xyloside

1991 • 102 citations

Unique Changes of Ganglion Cell Growth Cone Behavior Following Cell Adhesion Molecule Perturbations: A Time-Lapse Study of the Living Retina

1995 • 97 citations

Astrocyte topography and tenascin/cytotactin expression: correlation with the ability to support neuritic outgrowth

1990 • 97 citations

Neurite guidance by non-neuronal cells in culture: preferential outgrowth of peripheral neurites on glial as compared to nonglial cell surfaces

1985 • 97 citations

Vascular and astrocytic reactions during establishment of hippocampal transplants in adult host brain

1984 • 95 citations

Chronic regenerative changes in the spinal cord after cord compression injury in rats

1987 • 95 citations

The problem of neuronal regeneration in the central nervous system: I. The influence of spinal ganglia and nerve fragments grafted in the brain.

1942 • 94 citations

Chapter 46 Central nervous system regeneration: oligodendrocytes and myelin as non-permissive substrates for neurite growth

1988 • 94 citations

Chapter 11 Proteoglycans and other repulsive molecules in glial boundaries during development and regeneration of the nervous system

1996 • 94 citations

The problem of neuronal regeneration in the central nervous system: II. The insertion of peripheral nerve stumps into the brain.

1943 • 92 citations

Genetic influences on cellular reactions to spinal cord injury: A wound-healing response present in normal mice is impaired in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration

1996 • 92 citations

An in vitro model of wound healing in the CNS: Analysis of cell reaction and interaction at different ages

1989 • 90 citations

Modification of astrocytes in the spinal cord following dorsal root or peripheral nerve lesions

1990 • 90 citations

Post-transcriptional regulation of syndecan-1 expression by cAMP in peritoneal macrophages

1993 • 89 citations

Role of endothelin-1 in astrocyte responses after acute brain damage

1997 • 86 citations

Spinal axons in central nervous system scar tissue are closely related to laminin-immunoreactive astrocytes

1995 • 85 citations

Axonal regeneration and physiological activity following transection and immunological disruption of myelin within the hatchling chick spinal cord

1995 • 85 citations

Boundaries and Wounds, Glia and Glycoconjugates

1991 • 84 citations

Proteoglycan metabolism in normal and inflammatory human macrophages

1993 • 83 citations

The proteoglycan chondroitin sulfate is present in a subpopulation of cultured astrocytes and in their precursors

1987 • 82 citations

Astrocytes from adult rat optic nerves are nonpermissive for regenerating retinal ganglion cell axons

1995 • 82 citations

Characterization of glycosaminoglycans produced by primary astrocytes in vitro

1991 • 78 citations

Chondroitin Sulfate Proteoglycan and Tenascin in the Wounded Adult Mouse NeostriatumIn Vitro: Dopamine Neuron Attachment and Process Outgrowth

1996 • 77 citations

Regrowth of motor axons following spinal cord lesions: Distribution of laminin and collagen in the CNS scar tissue

1993 • 76 citations

Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord

1997 • 76 citations

Long Fibre Growth by Axons of Embryonic Mouse Hippocampal Neurons Microtransplanted into the Adult Rat Fimbria

1993 • 76 citations

Essentiality of a specific cellular terrain for growth of axons into a spinal cord lesion

1985 • 75 citations

Regrowth of lesioned dorsal root nerve fibers into the spinal cord of neonatal rats

1987 • 75 citations

Genetic influences on cellular reactions to spinal cord injury: Activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration

1996 • 74 citations

Tenascin-C expression by neurons and glial cells in the rat spinal cord: Changes during postnatal development and after dorsal root or sciatic nerve injury

1995 • 73 citations

Nerve growth factor enhances neurite arborization of adult sensory neurons; a study i single-cell culture

1990 • 73 citations

Serglycin-binding proteins in activated macrophages and platelets

1996 • 70 citations

Neurite Outgrowth Inhibitor of Gliotic Brain Tissue. Mode of Action and Cellular Localization, Studied with Specific Monoclonal Antibodies

1997 • 70 citations

Modulation of the Expression of Chondroitin Sulfate Proteoglycan in Stimulated Human Monocytes

1989 • 70 citations

Inflammatory Cytokines Interact to Modulate Extracellular Matrix and Astrocytic Support of Neurite Outgrowth

1997 • 68 citations

Cell proliferation in injured spinal cord. An electron microscopic study

1973 • 67 citations

A central nervous system keratan sulfate proteoglycan: localization to boundaries in the neonatal rat brain

1993 • 66 citations

Regeneration of axons in the optic nerve of the adult Browman-Wyse (BW) mutant rat

1992 • 63 citations

Regional Differences in Reactive Gliosis Induced by Substrate-Bound β-Amyloid

1994 • 61 citations

Extracellular matrix of cultured glial cells: Selective expression of chondroitin 4-sulfate by type-2 astrocytes and their progenitors

1990 • 59 citations

Reactive proliferation of astrocytes studied by immunohistochemistry for proliferating cell nuclear antigen

1992 • 59 citations

Restricted appearance of tenascin and chondroitin sulphate proteoglycans after transection and sprouting of adult rat postcommissural fornix

1995 • 58 citations

Histopathological reactions and axonal regeneration in the transected spinal cord of hibernating squirrels

1981 • 57 citations

Contribution of Peripheral Macrophages and Microglia to the Cellular Reaction after Mechanical or Neurotoxin-Induced Lesions of the Rat Brain

1994 • 56 citations

A monoclonal antibody (IN-1) which neutralizes neurite growth inhibitory proteins in the rat CNS recognizes antigens localized in CNS myelin

1994 • 56 citations

Neurite outgrowth inhibitors associated with glial cells and glial cell lines

1993 • 54 citations

Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein

1996 • 54 citations

Reinnervation of the mammalian spinal cord after neonatal dorsal root crush

1988 • 54 citations

Development and role of retinal glia in regeneration of ganglion cells following retinal injury.

1996 • 53 citations

Reaction of oligodendrocytes and astrocytes to trauma and implantation. A combined autoradiographic and immunohistochemical study.

1985 • 52 citations

GAP-43 in the axons of mammalian CNS neurons regenerating into peripheral nerve grafts

1991 • 52 citations

Synthesis of stromal glycosaminoglycans in response to injury

1995 • 51 citations

The mechanism of spinal cord cavitation following spinal cord transection

1977 • 51 citations

A SEARCH FOR TROPHIC INFLUENCE OF POSTERIOR SPINAL ROOTS ON SKELETAL MUSCLE, WITH A NOTE ON THE NERVE FIBRES FOUND IN THE PROXIMAL STUMPS OF THE ROOTS AFTER EXCISION OF THE ROOT GANGLIA

1931 • 50 citations

Chondroitin/Dermatan Sulphate Promotes the Survival of Neurons from Rat Embryonic Neocortex

1997 • 50 citations

Changing interactions between astrocytes and neurons during CNS maturation

1991 • 50 citations

High Molecular Weight Protein of Human Central Nervous System Myelin Inhibits Neurite Outgrowth: an Effect which can be Neutralized by the Monoclonal Antibody IN‐1

1997 • 50 citations

Morphological studies on neuroglia

1981 • 49 citations

Basal Lamina Formation by Astrocytes in Organotypic Cultures of Mouse Spinal Cord Tissue

1985 • 49 citations

Membrane‐anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan‐4–like heparan sulfate proteoglycan and a distinct chondroitin sulfate form

1993 • 46 citations

Molecular Correlates of Spinal Cord Repair in the Embryonic Chick: Heparan Sulfate and Chondroitin Sulfate Proteoglycans

1994 • 45 citations

The macrophage cell surface glycoprotein F4/80 is a highly glycosylated proteoglycan

1996 • 42 citations

Retinal neurite growth on astrocytes is not modified by extracellular matrix, anti‐L1 antibody, or oligodendrocytes

1991 • 41 citations

Cell density-dependent expression of chondroitin sulfate proteoglycan in cultured human monocytes.

1988 • 40 citations

Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog

1997 • 39 citations

Effects of chronic intrahippocampal infusion of lipopolysaccharide in the rat

1996 • 39 citations

A CNS specific proteoglycan associated with astrocytes in rat optic nerve

1992 • 37 citations

Reactive Astroglia Support Primary Dendritic but Not Axonal Outgrowth from Mouse Cortical Neuronsin Vitro

1996 • 36 citations

Comparative study of astrocytes and mononuclear leukocytes reacting to brain trauma in mice

1973 • 36 citations

Proteoglycans synthesized in vitro by nude and normal mouse peritoneal macrophages

1990 • 34 citations

Dorsal roots following anastomosis of the central stumps

1947 • 34 citations

Differentiation-associated changes in the expression of chondroitin sulfate proteoglycan in induced U-937 cells.

1988 • 33 citations

A comparison of the regeneration potential of dorsal root fibers into gray or white matter of the adult rat spinal cord

1990 • 33 citations

Effect of benzyl γ-<scp>d</scp>-xyloside on the biosynthesis of chondroitin sulphate proteoglycan in cultured human monocytes

1986 • 31 citations

Growth and degeneration of axons on astrocyte surfaces: Effects on extracellular matrix and on later axonal growth

1993 • 30 citations

Regeneration of dorsal root axons is related to specific non-neuronal cells lining NGF-treated intraspinal nitrocellulose implants

1992 • 30 citations

Degradation of collagen and proteoglycan by macrophages and fibroblasts Individual potentialities of each cell type and cooperative effects through the activation of fibroblasts by macrophages

1982 • 29 citations

Embryonic Optic Nerve Tissue Fails to Support Neurite Outgrowth by Central and Peripheral Neurons In Vitro

1993 • 28 citations

Genetic influences on cellular reactions to CNS injury: The reactive response of astrocytes in denervated neuropil regions in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration

1997 • 27 citations

Chondroitin 4-Sulfate Stimulates Regeneration of Goldfish Retinal Axons

1997 • 27 citations

Reinitiation of chondroitin sulphate proteoglycan synthesis in regenerating skeletal muscle

1988 • 26 citations

Effects of Axonal Injury on Astrocyte Proliferation and Morphologyin Vitro:Implications for Astrogliosis

1996 • 26 citations

The oligodendroglial reaction to brain stab wounds: An immunohistochemical study

1995 • 25 citations

The regeneration of peripheral nerves inserted into the cerebral cortex and the healing of cerebral lesions

1958 • 25 citations

Regrowth of anastomosed ventral root nerve fibers in the dorsal root of rats

1983 • 25 citations

A Novel Aspect of Thrombin in the Tissue Reaction Following Central Nervous System Injury

1994 • 24 citations

A chondroitin sulphate proteoglycan from human cultured glial and glioma cells. Structural and functional properties

1984 • 24 citations

Low-density lipoprotein binding affinity of arterial chondroitin sulfate proteoglycan variants modulates cholesteryl ester accumulation in macrophages

1995 • 24 citations

Regrowth of cholinergic and catecholaminergic neurons along a peripheral and central nervous pathway

1985 • 22 citations

Chondroitin sulfate proteoglycan and heparan sulfate proteoglycan production by cultured pigeon peritoneal macrophages

1992 • 16 citations

Chapter 29 Mammalian root-spinal cord regeneration

1988 • 15 citations

Growth Cones of Dorsal Root Ganglion but Not Retina Collapse and Avoid Oligodendrocytes in Culture

1995 • 12 citations

Sulfur-containing macromolecules in cultured monocyte-like cells

1988 • 11 citations

Proteoglycan biosynthesis in relation to differentiation of cord blood monocytes in vitro

1987 • 10 citations

Histological Factors Influencing the Growth of Axons into Lesions of the Mammalian Spinal Cord

1986 • 9 citations

Transient Morphological and Biochemical Alterations of Arterial Proteoglycan during Early Wound Healing

1993 • 6 citations