Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA.

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

1994 • 775 citations

Specific DNA binding of GAL4, a positive regulatory protein of yeast

1985 • 767 citations

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

1994 • 766 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Molecular Genetics of the Bithorax Complex in Drosophila melanogaster

1983 • 616 citations

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.

1982 • 575 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

1991 • 566 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

1992 • 552 citations

Vectors for Drosophila P-element-mediated transformation and tissue culture transfection

1988 • 547 citations

DNA position-specific repression of transcription by a Drosophila zinc finger protein.

1992 • 418 citations

Segmental distribution of bithorax complex proteins during Drosophila development

1985 • 397 citations

Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin

1993 • 360 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.

1994 • 346 citations

Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster.

1992 • 335 citations

The abdominal region of the bithorax complex

1985 • 326 citations

Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products

1993 • 317 citations

In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster

1989 • 302 citations

Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products

1992 • 292 citations

Position-effect variegation after 60 years

1990 • 286 citations

Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

1994 • 267 citations

Boundaries and fields in early embryos

1992 • 239 citations

Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.

1992 • 231 citations

A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation.

1990 • 225 citations

Spatial regulation of antennapedia and bithorax gene expression by the Polycomb locus in Drosophila

1986 • 204 citations

polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila.

1993 • 200 citations

Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly.

1993 • 191 citations

Yeast activators stimulate plant gene expression

1988 • 167 citations

Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.

1991 • 162 citations

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.

1993 • 154 citations

Transcriptional silencing by the Polycomb protein in Drosophila embryos.

1995 • 143 citations

A germline transformation analysis reveals flexibility in the organization of beat shock consensus elements

1987 • 142 citations

Role of the Histone Amino Termini in Facilitated Binding of a Transcription Factor, GAL4-AH, to Nucleosome Cores

1994 • 136 citations

Position effect variegation in Drosophila: Towards a genetics of chromatin assembly

1989 • 134 citations

Silencers in abdominal-B, a homeotic Drosophila gene.

1993 • 130 citations

Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells.

1994 • 123 citations

Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex

1995 • 119 citations

Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions.

1988 • 118 citations

GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo.

1993 • 109 citations

Homeogene expression patterns and chromosomal imprinting.

1990 • 104 citations

Mechanism of transcriptional antirepression by GAL4-VP16.

1992 • 97 citations

Cloning and characterization of the scalloped region of Drosophila melanogaster.

1991 • 46 citations

Mechanisms for the construction and developmental control of heterochromatin formation and imprinted chromosome domains

1990 • 46 citations

TSF1 to TSF6, required for silencing the Saccharomyces cerevisiae GAL genes, are global regulatory genes.

1993 • 29 citations