A germline transformation analysis reveals flexibility in the organization of beat shock consensus elements

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

Specific DNA binding of GAL4, a positive regulatory protein of yeast

1985 • 767 citations

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene

1986 • 562 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Saccharomyces cerevisiae GAL1-GAL10 Divergent Promoter Region: Location and Function of the Upstream Activating Sequence UAS_G

1984 • 395 citations

Transient expression of genes introduced into cultured cells of Drosophila.

1983 • 370 citations

Accumulation of a specific subset of D. melanogaster heat shock mRNAs in normal development without heat shock

1983 • 365 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin

1984 • 329 citations

New heat shock puffs and β=galactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene

1983 • 323 citations

Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene

1985 • 291 citations

A short nucleotide sequence required for regulation of HIS4 by the general control system of yeast

1983 • 288 citations

Determinants of heat shock-induced chromosome puffing

1985 • 281 citations

The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence

1984 • 272 citations

The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter

1983 • 241 citations

Heat shock regulatory elements function as an inducible enhancer in the xenopus hsp70 gene and when linked to a heterologous promoter

1986 • 239 citations

Upstream elements necessary for optimal function of the hsp 70 promoter in transformed flies

1984 • 213 citations

Spatial and temporal pattern of hsp26 expression during normal development.

1986 • 193 citations

The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites.

1986 • 167 citations

DNA loops induced by cooperative binding of λ repressor

1986 • 165 citations

Extensive regions of homology in front of the two hsp70 heat shock variant genes in Drosophila melanogaster

1981 • 161 citations

Ecdysterone induces the transcription of four heat-shock genes in Drosophila S3 cells and imaginal discs

1982 • 160 citations

Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis

1986 • 158 citations

A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast.

1985 • 144 citations

Separate regulatory elements for the heat-inducible and ovarian expression of the drosophila hsp26 gene

1985 • 138 citations

Activation of the Drosophila hsp27 promoter by heat shock and by ecdysone involves independent and remote regulatory sequences

1986 • 128 citations

Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein

1979 • 121 citations

Heat shock and ecdysterone activation of the Drosophila melanogaster hsp23 gene; a sequence element implied in developmental regulation.

1986 • 112 citations

Locus Encoding a Family of Small Heat Shock Genes in Caenorhabditis elegans: Two Genes Duplicated to Form a 3.8-Kilobase Inverted Repeat

1985 • 110 citations

Binding of Drosophila heat-shock gene transcription factor to the hsp 70 promoter. Evidence for symmetric and dynamic interactions.

1986 • 93 citations

Nucleosomal Instability and Induction of New Upstream Protein-DNA Associations Accompany Activation of Four Small Heat Shock Protein Genes in Drosophila melanogaster

1986 • 90 citations

A CCAAT box confers cell-type-specific regulation on the Xenopus hsp70 gene in oocytes

1986 • 78 citations

The Heat Shock Consensus Sequence Is Not Sufficient for hsp70 Gene Expression in Drosophila melanogaster

1985 • 73 citations

Functional analysis of the glucocorticoid regulatory elements present in the mouse mammary tumor virus long terminal repeat

1986 • 68 citations

Cloning and characterization of nine heat-shock-induced mRNAs of Drosophila melanogaster

1981 • 63 citations

Sequence requirement for expression of the Drosophila melanogaster heat shock protein hsp22 gene during heat shock and normal development.

1986 • 55 citations

Several hundred base pairs upstream of Drosophila hsp23 and 26 genes are required for their heat induction in transformed flies.

1986 • 50 citations

Sequences involved in temperature and ecdysterone-induced transcription are located in separate regions of a Drosophila melanogaster heat shock gene.

1986 • 48 citations

Constitutive and Coordinately Regulated Transcription of Yeast Genes: Promoter Elements, Positive and Negative Regulatory Sites, and DNA Binding Proteins

1985 • 39 citations

A consensus sequence polymer inhibits in vivo expression of heat shock genes.

1986 • 33 citations

Sequence Requirement for Expression of the Drosophila melanogaster Heat Shock Protein hsp22 Gene During Heat Shock and Normal Development

1986 • 18 citations

A Consensus Sequence Polymer Inhibits in Vivo Expression of Heat Shock Genes

1986 • 18 citations

Sequences Involved in Temperature and Ecdysterone-Induced Transcription Are Located in Separate Regions of a Drosophila melanogaster Heat Shock Gene

1986 • 13 citations