P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

p53 function and dysfunction

1992 • 1,918 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Gain of function mutations in p53

1993 • 876 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 • 664 citations

P53 expression in breast cancer

1988 • 612 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

1982 • 448 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

1990 • 386 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

1992 • 375 citations

Multifactorial analysis of p53 alteration in human cancer: A review

1994 • 359 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Allelic Loss in Colorectal Carcinoma

1989 • 338 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Prognostic significance of p53 mutations and 3p deletions in primary, resected non-small cell lung cancer

1995 • 333 citations

Cancer: causes, occurrence and control

1991 • 325 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

Serum p53 antibodies as early markers of lung cancer

1995 • 301 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.

1992 • 299 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot.

1992 • 283 citations

Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

1992 • 281 citations

p53 Mutations in non-small cell lung cancer in Japan: Association between mutations and smoking

1992 • 280 citations

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]

1989 • 273 citations

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

1991 • 262 citations

High frequency mutagenesis by a DNA methyltransferase

1992 • 259 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

p53 as an Independent Prognostic Marker in Lymph Node-Negative Breast Cancer Patients

1993 • 243 citations

p53 expression in colorectal tumors.

1991 • 243 citations

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

1992 • 233 citations

Prognostic significance of p53 overexpression in gastric and colorectal carcinoma

1992 • 231 citations

Allelotype study of primary hepatocellular carcinoma

1991 • 223 citations

The specificity of UV-induced mutations at an endogenous locus in mammalian cells.

1987 • 216 citations

Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

1994 • 213 citations

p53 Protein accumulates frequently in early bronchial neoplasia

1994 • 211 citations

MUTATIONAL SPECIFICITY IN BACTERIA

1983 • 208 citations

Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis

1990 • 205 citations

Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors.

1993 • 200 citations

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

1992 • 198 citations

Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions.

1982 • 184 citations

Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.

1992 • 182 citations

Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products

1990 • 175 citations

Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer

1991 • 174 citations

Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface.

1993 • 173 citations

Radioimmunoassay of the cellular protein p53 in mouse and human cell lines.

1982 • 172 citations

A mutant p53 tumor suppressor protein is a target for peptide-induced CD8+ cytotoxic T-cells.

1993 • 171 citations

Cell Cycle-Dependent Strand Bias for UV-Induced Mutations in the Transcribed Strand of Excision Repair-Proficient Human Fibroblasts but Not in Repair-Deficient Cells

1991 • 169 citations

Carcinogens leave fingerprints

1992 • 169 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

Cancer: Causes, occurrence and control

1991 • 159 citations

Mutational specificity of alkylating agents and the influence of DNA repair

1990 • 157 citations

The origin of point mutations in human tumor cells.

1992 • 154 citations

p53 allele losses, mutations and expression in breast cancer and their relationship to clinico‐pathological parameters

1992 • 152 citations

Relation between p53 overexpression and established prognostic factors in breast cancer.

1991 • 149 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

The regulation of p53 function: Steiner award lecture

1994 • 145 citations

Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 protein

1994 • 143 citations

Prognostic significance of circulating P53 antibodies in patients undergoing surgery for locoregional breast cancer

1995 • 142 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Anti-p53 Antibodies in Sera of Workers Occupationally Exposed to Vinyl Chloride

1995 • 138 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 138 citations

Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma

1987 • 134 citations

Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts.

1992 • 130 citations

Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells

1988 • 124 citations

Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.

1993 • 122 citations

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1993 • 118 citations

Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma.

1989 • 116 citations

Clinical utility of the immunocytochemical detection of p53 protein in cytological specimens.

1994 • 112 citations

Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia

1990 • 108 citations

Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells.

1991 • 107 citations

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

1995 • 101 citations

Deletion mapping of the medulloblastoma locus on chromosome 17p

1990 • 88 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

GERMLINE p53 MUTATIONS AND HERITABLE CANCER

1994 • 78 citations

Kinds and location of mutations induced by (±)-7β,8α- dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts

1991 • 78 citations

p53 from basic research to clinical applications.

1992 • 67 citations

Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif.

1994 • 62 citations

Gene therapy of cancer through restoration of tumor-suppressor functions?

1992 • 55 citations

The role and prognostic significance of p53 gene alterations in breast cancer

1993 • 53 citations

p53 and Human Malignancies

1991 • 49 citations

The dominating effect of mutant p53

1995 • 48 citations

Mutational Spectrometry in Animal Toxicity Testing

1990 • 29 citations

The clinical relevance of the p53 tumour suppressor gene*

1994 • 28 citations

p53 gene alterations in human hematological malignancies: a review.

1991 • 14 citations