Interleukin-5: An overview

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Interleukin-5, eosinophils, and disease

1992 • 874 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Interleukin-5, eosinophils, and disease

1992 • 771 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.

1988 • 619 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Asthma and inflammation.

2012 • 569 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors.

1988 • 528 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

1993 • 247 citations

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

1990 • 240 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

1987 • 236 citations

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

1989 • 234 citations

Molecular cloning and expression of the murine interleukin-5 receptor.

1990 • 227 citations

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.

1990 • 213 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

1993 • 208 citations

Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).

1992 • 206 citations

Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue

1986 • 205 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Molecular cloning and expression of the human interleukin 5 receptor.

1992 • 199 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays

1987 • 180 citations

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.

1994 • 178 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

1980 • 166 citations

Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.

1989 • 149 citations

Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor.

1991 • 144 citations

A Critical Cytoplasmic Domain of the Interleukin-5 (IL-5) Receptor α Chain and Its Function in IL-5-Mediated Growth Signal Transduction

1994 • 139 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

Interleukin-5 and Its Receptor System: Implications in the Immune System and Inflammation

1994 • 135 citations

Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1992 • 128 citations

CBA/N Immune Defective Mice; Evidence for the Failure of a B Cell Subpopulation to be Expressed

1982 • 121 citations

Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex.

1992 • 117 citations

Distribution of IL-5 receptor-positive B cells. Expression of IL-5 receptor on Ly-1(CD5)+ B cells.

1990 • 116 citations

Molecular basis of a high affinity murine interleukin-5 receptor.

1991 • 112 citations

Role of Bruton's tyrosine kinase in immunodeficiency

1994 • 112 citations

Reconstitution of the functional receptors for murine and human interleukin 5.

1993 • 111 citations

Enhancement of human basophil histamine release by interleukin 5.

1990 • 103 citations

Monoclonal antibodies reactive with the mouse interleukin 5 receptor.

1989 • 103 citations

BCGFII activity on activated B cells of a purified murine T cell-replacing factor (TRF) from a T cell hybridoma (B151K12).

1985 • 100 citations

Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines.

1989 • 99 citations

Tyrosine phosphorylation of receptor beta subunits and common substrates in response to interleukin-3 and granulocyte-macrophage colony-stimulating factor.

1992 • 90 citations

Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells.

1993 • 86 citations

Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line.

1981 • 81 citations

Interleukin-5

1992 • 77 citations

Differential regulation of IgA production by TGF-β and IL-5: TGF-β induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells

1992 • 74 citations

Structure-function analysis of interleukin-5 utilizing mouse/human chimeric molecules.

1991 • 68 citations

IL-5 receptor positive B cells, but not eosinophils, are functionally and numerically influenced in mice carrying the X-linked immune defect

1993 • 68 citations

Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line

1990 • 65 citations

Interleukin-5 induces maturation but not class switching of surface IgA-positive B cells into IgA-secreting cells.

1989 • 63 citations

Establishment of IL-5-Dependent Early B Cell Lines by Long-Term Bone Marrow Cultures

1989 • 60 citations

In vivoadministration of antibody to murine IL-5 receptor inhibits eosinophilia of IL-5 transgenic mice

1991 • 57 citations

Conversion of Normal Ly-1-Positive B-Lineage Cells into Ly-1-Positive Macrophages in Long-Term Bone Marrow Cultures

1990 • 53 citations

Characterization of the murine interleukin 5 receptor by using a monoclonal antibody

1990 • 53 citations

Defective IL-5-receptor-mediated signaling in B cells of X-linked immunodeficient mice

1995 • 52 citations

Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis.

1996 • 44 citations

Human interleukin‐5 induces staphylococcal A Cowan 1 strain‐activated human B cells to secrete IgM

1993 • 43 citations

Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching.

1993 • 39 citations

Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.

1992 • 29 citations

The Murine Interleukin-5 Receptor α-Subunit Gene: Characterization of the Gene Structure and Chromosome Mapping

1994 • 27 citations

Molecular characterization of the β chain of the murine interleukin 5 receptor

1991 • 26 citations

Biochemical and functional characterization of soluble form of IL-5 receptor α (sIL-5Rα) Development of ELISA system for detection of sIL-5Rα

1994 • 22 citations

Localization of the gene encoding the α subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24–3p26

1992 • 20 citations

Interleukin-5 Levels of Pleural Fluid and Serum Samples in a Patient with PIE Syndrome

1992 • 13 citations