Role of Bruton's tyrosine kinase in immunodeficiency

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Cytokine signal transduction

1994 • 1,358 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

The when and how of Src regulation

1993 • 543 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

1992 • 506 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

Development and applications of a molecular genetic linkage map of the mouse genome

1991 • 427 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells.

1994 • 301 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

B Lymphocyte Precursors in Human Bone Marrow: An Analysis of Normal Individuals and Patients with Antibody-Deficiency States

1978 • 236 citations

Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.

1993 • 232 citations

Genetics of src: Structure and Functional Organization of a Protein Tyrosine Kinase

1989 • 197 citations

B cells in patients with X-linked agammaglobulinemia.

1985 • 186 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Expression of the Gene Defect in X-Linked Agammaglobulinemia

1986 • 177 citations

Phenotypic features and proliferative activity of B cell progenitors in X-linked agammaglobulinemia.

1990 • 152 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.

1993 • 142 citations

Molecular Approaches to Analysis of X-Linked Immunodeficiencies

1992 • 139 citations

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice

1994 • 131 citations

Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.

1982 • 131 citations

Structure and Expression of Novel Protein-Tyrosine Kinases, EMB and EMT, in Hematopoietic Cells

1993 • 131 citations

A Point Mutation in the SH2 Domain of Bruton's Tyrosine Kinase in Atypical X-Linked Agammaglobulinemia

1994 • 129 citations

Mapping of the X-linked agammaglobulinemia locus by use of restriction fragment-length polymorphism.

1986 • 123 citations

X-Linked Immune Deficiency (xid) of CBA/N Mice

1986 • 123 citations

Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB x NZW)F1 pre-B cells.

1992 • 116 citations

Bruton's Tyrosine Kinase is a Key Regulator in B‐Cell Development

1994 • 107 citations

Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking.

1992 • 101 citations

Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis

1994 • 101 citations

Primary sequence and developmental expression of a novel Drosophila melanogaster src gene.

1987 • 98 citations

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

1994 • 87 citations

PH domains and phospholipases — a meaningful relationship?

1994 • 72 citations

IL-5 receptor positive B cells, but not eosinophils, are functionally and numerically influenced in mice carrying the X-linked immune defect

1993 • 68 citations

Mapping of a gene for X-linked agammaglobulinemia and evidence for genetic heterogeneity

1986 • 64 citations

Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells.

1993 • 61 citations

Identification of a closely linked DNA marker, DXS178, to further refine the X-linked agammaglobulinemia locus

1990 • 61 citations

Close linkage of probe p212 (DXS178) to X-linked agammaglobulinemia

1989 • 60 citations

Close linkage of random DNA fragments from Xq 21.3–22 to X-linked agammaglobulinaemia (XLA)

1987 • 57 citations

Oncogenic Activation of c-ABL by Mutation within Its Last Exon

1993 • 51 citations

Unbalanced X chromosome mosaicism in B cells of mice with X-linked immunodeficiency.

1983 • 50 citations

Linkage Analysis and Physical Mapping near the Gene for X-Linked Agammaglobulinemia at Xq22

1993 • 49 citations

Oncogenic activation of c-ABL by mutation within its last exon.

1993 • 38 citations

X-linked agammaglobulinemia - gene cloning and future prospects

1993 • 37 citations

Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire.

1993 • 30 citations

Induction of partial chimerism in nonirradiated B-lymphocyte-deficient CBA/N mice.

1978 • 14 citations

Establishment of a Reproducible Culture Technique for the Selective Growth of B-Cell Progenitors

1992 • 13 citations

Functionality of Clonal Lymphoid Progenitor Cells Expressing the P210 BCR/ABL Oncogene

1990 • 2 citations