Prognostic factors in colorectal cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood

1993 • 3,197 citations

Hepatogastroenterology

2011 • 2,829 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

RECURRENCE AND SURVIVAL AFTER TOTAL MESORECTAL EXCISION FOR RECTAL CANCER

1986 • 2,585 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

A Case–Control Study of Screening Sigmoidoscopy and Mortality from Colorectal Cancer

1992 • 1,757 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

The Spread of Rectal Cancer and its Effect on Prognosis

1958 • 807 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer

1994 • 708 citations

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

1992 • 703 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Patterns of recurrence of rectal cancer after potentially curative surgery

1983 • 543 citations

The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases

1986 • 539 citations

Preoperative Carcinoembryonic Antigen Level as a Prognostic Indicator in Colorectal Cancer

1978 • 471 citations

A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer

1985 • 467 citations

Microsatellite alterations as clonal markers for the detection of human cancer.

1994 • 448 citations

Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival

1994 • 413 citations

Mucinous carcinoma of the colon and rectum

1976 • 386 citations

Allelic Loss in Colorectal Carcinoma

1989 • 338 citations

The DCC Protein and Prognosis in Colorectal Cancer

1996 • 307 citations

Metastases in Small Lymph Nodes From Colon Cancer

1987 • 288 citations

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]

1989 • 273 citations

Prevalence and prognosis of individual clinical and pathologic variables associated with colorectal carcinoma

1967 • 258 citations

Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.

1996 • 252 citations

Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer

1993 • 249 citations

The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma

1994 • 246 citations

Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of 579 patients

1994 • 245 citations

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

1992 • 233 citations

Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience

1986 • 222 citations

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

1991 • 221 citations

Prognostic factors in carcinoma of the colon and rectum

1968 • 220 citations

A multivariate analysis of pathologic prognostic indicators in large bowel cancer

1988 • 214 citations

Predictors of survival after curative resection of carcinoma of the colon and rectum

1987 • 213 citations

Patterns of recurrence following curative resection alone for adenocarcinoma of the rectum and sigmoid colon

1981 • 213 citations

Survival and acquired genetic alterations in colorectal cancer

1992 • 208 citations

Vascular and neural invasion in colorectal carcinoma.Incidence and prognostic significance

1988 • 206 citations

Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum

1984 • 195 citations

Clearance technique for the detection of lymph nodes in colorectal cancer

1986 • 186 citations

c-myc oncogene expression in colorectal cancer

1987 • 185 citations

Cytoplasmic Accumulation of p53 Protein: an Independent Prognostic Indicator in Colorectal Adenocarcinomas

1994 • 185 citations

Expression of p21ras in fresh primary and metastatic human colorectal tumors.

1985 • 181 citations

PREDICTION OF OUTCOME AFTER CURATIVE RESECTION FOR LARGE BOWEL CANCER

1986 • 180 citations

Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas

1987 • 179 citations

Peculiarities of mucinous colorectal carcinoma

1985 • 176 citations

The Prognostic Significance of Tumor Location and Bowel Obstruction in Dukes B and C Colorectal Cancer

1983 • 176 citations

Venous and neural invasion as predictors of recurrence in rectal adenocarcinoma

1991 • 173 citations

MULTIVARIATE ANALYSIS OF PROGNOSTIC FACTORS FOR OPERABLE RECTAL CANCER

1984 • 173 citations

THE GRADING AND PROGNOSIS OF CARCINOMA OF THE COLON AND RECTUM

1939 • 167 citations

Detection of the c-myc oncogene product in colonic polyps and carcinomas

1986 • 164 citations

Resectable adenocarcinoma of the rectosigmoid and rectum. I. Patterns of failure and survival

1988 • 163 citations

Carcinoembryonic Antigen (CEA) as a Prognostic and Monitoring Test in Clinically Complete Resection of Colorectal Carcinoma

1976 • 162 citations

Perforative Carcinoma of Colon and Rectum

1974 • 154 citations

Management of severe obstruction of the large bowel due to malignant disease

1974 • 151 citations

Colorectal Cancer

1987 • 142 citations

Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis

1992 • 140 citations

A CONSIDERATION OF PATHOLOGICAL FACTORS INFLUENCING FIVE YEAR SURVIVAL IN RADICAL RESECTION OF THE LARGE BOWEL AND RECTUM FOR CARCINOMA

1947 • 139 citations

THE SPREAD OF CARCINOMA OF THE RECTUM

1943 • 138 citations

p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.

1994 • 136 citations

[Long-term results of surgical therapy of colon cancer. Results of the Colorectal Cancer Study Group].

1994 • 133 citations

The Use of Preoperative Plasma CEA Levels for the Stratification of Patients After Curative Resection of Colorectal Cancers

1980 • 126 citations

Periodic health examination

1986 • 123 citations

Lymphatic vessel invasion is an independent prognostic factor for survival in colorectal cancer

1989 • 120 citations

Type and number of Ki-ras point mutations relate to stage of human colorectal cancer.

1994 • 111 citations

Clinical and pathologic prognostic indicators in colorectal cancer. A population-based study.

1992 • 111 citations

Prognostic factors in colonic cancer

1989 • 111 citations

Obstructive and perforative colonic carcinoma: patterns of failure.

1985 • 110 citations

Prognostic factors in rectal carcinoma

1989 • 110 citations

Determination of Tumor Aggressiveness in Colorectal Cancer by K-ras-2 Analysis

1993 • 107 citations

Local recurrence after curative resection of colorectal adenocarcinoma.

1990 • 107 citations

A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients

1996 • 102 citations

Factors influencing survival after resection in cancer of the colon and rectum

1969 • 99 citations

Pathological studies in rectal cancer

1980 • 94 citations

Carcinoma of the Colon and Rectum

1969 • 89 citations

Tumor DNA Content in Resectable, Primary Colorectal Carcinoma

1989 • 86 citations

Prognostic value of pathological characteristics of colorectal cancer

1995 • 84 citations

Obstruction and Perforation in Colo-Rectal Cancer

1971 • 83 citations

A simultaneous flow cytometric assay for c-myc oncoprotein and DNA in nuclei from paraffin embedded material

1985 • 83 citations

Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas

1996 • 82 citations

Prognosis in Colon Cancer

1975 • 82 citations

Current status of adjuvant chemotherapy for colorectal cancer: Can molecular markers play a role in predicting prognosis?

1992 • 78 citations

Perforation in cancer of the colon and rectum

1967 • 77 citations

p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

1997 • 77 citations

Mucinous carcinomas of the colon and rectum and their relation to polyps

1982 • 77 citations

Prognostic significance of vascular invasion in colorectal cancer of Dukes' B class

1977 • 73 citations

Some prognostic factors in survival of patients with cancer of the colon and rectum

1975 • 72 citations

The relationship of depth of penetration and tumor size to the number of positive nodes in dukes C colorectal cancer

1984 • 72 citations

Colorectal adenocarcinoma in patients less than 40 years old

1976 • 70 citations

Carcinoembryonic Antigen and Prognosis in Patients with Colon Cancer

1975 • 70 citations

Prognostic value of preoperative serum CEA level compared to clinical staging. I. Colorectal carcinoma

1981 • 70 citations

REGIONAL LYMPHATIC METASTASES OF CARCINOMA OF THE COLON

1941 • 68 citations

Prognostic factors in colorectal cancer: Current status and new trends

1991 • 64 citations

Automatic identification of surgical and orthodontic instruments.

1994 • 64 citations

Independent prognostic value of ploidy in colorectal cancer. A prospective study using image cytometry

1990 • 63 citations

Fecal occult blood screening for colorectal cancer in a Veterans Administration hospital

1983 • 62 citations

Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis

1996 • 58 citations

Mucoid carcinoma of the rectum

1951 • 58 citations

PROGNOSTIC SIGNIFICANCE OF p53 ABNORMALITIES IN COLORECTAL CARCINOMA DETECTED BY PCR-SSCP AND IMMUNOHISTOCHEMICAL ANALYSIS

1996 • 57 citations

Pre- and postoperative uses of CEA

1978 • 56 citations

Current status of adjuvant chemotherapy for colorectal cancer: Can molecular markers play a role in predicting prognosis?

1992 • 54 citations

Clinical significance of the preoperative plasma carcinoembryonic antigen (CEA) level in patients with carcinoma of the large bowel

1982 • 50 citations

An analysis of 284 patients with perforative carcinoma of the colon.

1966 • 50 citations

Obstruction In Cancer Of The Colon

1967 • 48 citations

K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.

1996 • 48 citations

Prognostic markers for colorectal cancer: Expression of P53 and BCL2

1997 • 46 citations

Predictive value of plasma CEA levels

1982 • 46 citations

Detection of oncogene mutation from neoplastic colonic cells exfoliated in feces

1996 • 46 citations

Immunohistological p53 staining is of limited value in the staging and prognostic prediction of colorectal cancer.

1996 • 45 citations

Postoperative survival of patients with potentially curable cancer of the colon

1985 • 42 citations

Pre-operative carcino-embryonic antigen and survival in patients with colorectal cancer

1984 • 41 citations

Complete colonic obstruction due to adenocarcinoma.

1962 • 41 citations

Prognostic factors in japanese patients with colorectal cancer: The significance of large bowel obstruction—univariate and multivariate analyses

1991 • 39 citations

THE LATERAL SPREAD OF CARCINOMA THE RECTUM

1955 • 37 citations

Pathologic studies in colorectal cancer. A guide to the surgical pathology examination of colorectal specimens and review of features of prognostic significance.

1982 • 37 citations

Periodic health examination, 1994 update: 2. Screening strategies for colorectal cancer. Canadian Task Force on the Periodic Health Examination.

1994 • 35 citations

Faecal occult blood testing and colonoscopy in the surveillance of subjects at high risk of colorectal neoplasia

1995 • 35 citations

Prognostic significance of p53 and c-erbB-2 immunohistochemical evaluation in colorectal adenocarcinoma.

1995 • 32 citations

Accurate specimen preparation and examination is mandatory to detect lymph nodes and avoid understaging in colorectal cancer

1992 • 30 citations

Prognostic value of the histochemical expression of Helix pomatia agglutinin in advanced colorectal cancer

1994 • 28 citations

Preoperative CEA level: a prognostic test in patients with colorectal carcinoma.

1980 • 28 citations

p53 Nuclear overexpression may not be an independent prognostic marker in early colorectal cancer

1995 • 27 citations

Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma

1997 • 25 citations

Morphological predictors of survival in colorectal carcinoma: Univariate and multivariate analysis

1987 • 24 citations

Carcinoembryonic antigen (CEA) and alkaline phosphatase in progressive colorectal cancer with special reference to patient survival

1986 • 21 citations

Current views related to management of large bowel obstruction caused by carcinoma of the colon

1962 • 21 citations

Trisomy 18: A nine year review

1988 • 19 citations

Factors of prognostic value in long-term survival of colorectal cancer patients.

1991 • 18 citations

Preoperative carcinoembryonic antigen and prognosis in patients with colorectal cancer.

1985 • 16 citations

Immunohisto-chemical p53 staining is of limited value in the staging and prognostic prediction of colorectal cancer.

1996 • 13 citations

Clinico-pathological correlation and prognostic significance of nuclear p53 protein in colorectal cancer. Colorectal Cancer Study Group of the University and Health Care District of Modena.

1996 • 12 citations

DNA polymerase alpha positive-cell rate in colorectal cancer and its relationship to prognosis

1992 • 10 citations

Two-year follow-up study of patients with known serum concentrations of carcinoembryonic antigen.

1977 • 6 citations

Carcinoma of the colon and rectum; a study of 353 cases with special reference to prognosis.

1956 • 6 citations

Accumulation of p53 in relation to long-term prognosis in colorectal carcinoma

1997 • 5 citations