Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Exercise training increases size of hippocampus and improves memory

2011 • 4,105 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

The Neuroendocrinology of Stress: A Never Ending Story

2008 • 3,415 citations

Exercise: a behavioral intervention to enhance brain health and plasticity

2002 • 2,571 citations

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

Exercise builds brain health: key roles of growth factor cascades and inflammation

2007 • 2,048 citations

Neurotrophin-regulated signalling pathways

2006 • 2,046 citations

Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

2005 • 2,005 citations

Dynamics of Hippocampal Neurogenesis in Adult Humans

2013 • 1,671 citations

Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons

2001 • 1,518 citations

Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus

2001 • 1,475 citations

Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older

2006 • 1,444 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

2004 • 1,345 citations

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

2007 • 1,288 citations

Transport of brain-derived neurotrophic factor across the blood–brain barrier

1998 • 1,258 citations

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

2013 • 1,068 citations

The role of exercise and PGC1α in inflammation and chronic disease

2008 • 995 citations

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

2002 • 932 citations

Stem and Progenitor Cells: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations

2001 • 928 citations

Brain-derived neurotrophic factor in neurodegenerative diseases

2009 • 886 citations

Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise

2009 • 834 citations

BDNF and Synaptic Plasticity, Cognitive Function, and Dysfunction

2014 • 825 citations

A BDNF autocrine loop in adult sensory neurons prevents cell death

1995 • 743 citations

Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus

2005 • 741 citations

A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

2014 • 684 citations

Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease

2010 • 666 citations

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

2013 • 657 citations

Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus

2004 • 617 citations

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

2008 • 607 citations

Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

2006 • 590 citations

Adenoviral Brain-Derived Neurotrophic Factor Induces Both Neostriatal and Olfactory Neuronal Recruitment from Endogenous Progenitor Cells in the Adult Forebrain

2001 • 531 citations

The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: Results of a one‐year exercise intervention

2012 • 490 citations

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

2016 • 446 citations

Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression

1999 • 405 citations

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

2008 • 383 citations

Regulation of hippocampal synaptic plasticity by BDNF

2014 • 370 citations

Neurobiological markers of exercise-related brain plasticity in older adults

2012 • 369 citations

Oxidative stress in athletes during extreme endurance exercise

2001 • 354 citations

p75NTR – live or let die

2005 • 305 citations

Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus

1994 • 301 citations

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

2014 • 298 citations

BDNF Promotes Differentiation and Maturation of Adult-born Neurons through GABAergic Transmission

2012 • 262 citations

Exercise differentially regulates synaptic proteins associated to the function of BDNF

2006 • 242 citations

Antioxidant response to oxidative stress induced by exhaustive exercise

2004 • 216 citations

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation

2009 • 211 citations

Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development

2007 • 209 citations

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

2013 • 209 citations

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

2008 • 188 citations

BDNF Is Expressed in Skeletal Muscle Satellite Cells and Inhibits Myogenic Differentiation

2006 • 182 citations

The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review.

2009 • 174 citations

Role of BDNF epigenetics in activity-dependent neuronal plasticity

2013 • 168 citations

Immunocytochemical detection of 5′-bromodeoxyuridine incorporation in the central nervous system of the mouse

1989 • 153 citations

BDNF control of adult SVZ neurogenesis

2011 • 139 citations

Physical exercise, reactive oxygen species and neuroprotection

2016 • 130 citations

Brain size and limits to adult neurogenesis

2015 • 127 citations

Traffic at the intersection of neurotrophic factor signaling and neurodegeneration

2003 • 127 citations

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Moderates an Effect of Physical Activity on Working Memory Performance

2013 • 126 citations

Brain‐derived neurotrophic factor regulates AMPA receptor trafficking to post‐synaptic densities via IP3R and TRPC calcium signaling

2007 • 116 citations

Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running

2003 • 114 citations

Neural Stem Cells and Neurogenesis in the Adult

2012 • 108 citations

Endurance factors improve hippocampal neurogenesis and spatial memory in mice

2011 • 102 citations

Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis

2011 • 100 citations

Estrogen and adult neurogenesis in the amygdala and hypothalamus

2007 • 97 citations

How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation

2017 • 83 citations

High Plasticity of New Granule Cells in the Aging Hippocampus

2017 • 80 citations

Exercise ameliorates cognition impairment due to restraint stress-induced oxidative insult and reduced BDNF level

2013 • 70 citations

BDNF genotype potentially modifying the association between incident stroke and depression

2007 • 63 citations

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

2015 • 62 citations

Plasma BDNF concentration, Val66Met genetic variant and depression‐related personality traits

2010 • 61 citations

Pattern Separation: A Potential Marker of Impaired Hippocampal Adult Neurogenesis in Major Depressive Disorder

2017 • 54 citations

BDNF polymorphism predicts the rate of decline in skilled task performance and hippocampal volume in healthy individuals

2011 • 44 citations

Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats

2015 • 38 citations

Colorado stride (COSTRIDE): testing genetic and physiological moderators of response to an intervention to increase physical activity

2013 • 19 citations