High Plasticity of New Granule Cells in the Aging Hippocampus

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

The Hallmarks of Aging

2013 • 12,238 citations

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

2009 • 6,324 citations

Exercise training increases size of hippocampus and improves memory

2011 • 4,105 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

2005 • 2,005 citations

Neurotrophin regulation of neural circuit development and function

2012 • 1,726 citations

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

2011 • 1,575 citations

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

2009 • 1,563 citations

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

2011 • 1,458 citations

Neural mechanisms of ageing and cognitive decline

2010 • 1,223 citations

GABA regulates synaptic integration of newly generated neurons in the adult brain

2005 • 1,221 citations

Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus

2006 • 1,193 citations

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

1998 • 1,135 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

2009 • 931 citations

A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain

2007 • 886 citations

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

2011 • 823 citations

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

2011 • 796 citations

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

2013 • 731 citations

Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development

2005 • 646 citations

The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands

2003 • 597 citations

NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

2006 • 594 citations

Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons

1998 • 521 citations

Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature Stage

2007 • 505 citations

Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity

1996 • 503 citations

Chemogenetic Tools to Interrogate Brain Functions

2014 • 470 citations

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

2012 • 447 citations

Optical controlling reveals time-dependent roles for adult-born dentate granule cells

2012 • 399 citations

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

2008 • 383 citations

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

2012 • 376 citations

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

1998 • 360 citations

Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons

2012 • 359 citations

Running throughout middle‐age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

2012 • 288 citations

Can physical exercise in old age improve memory and hippocampal function?

2016 • 282 citations

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

2017 • 269 citations

BDNF Promotes Differentiation and Maturation of Adult-born Neurons through GABAergic Transmission

2012 • 262 citations

Reliable Activation of Immature Neurons in the Adult Hippocampus

2009 • 258 citations

The exercise-induced expression of BDNF within the hippocampus varies across life-span

2005 • 256 citations

Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis

2015 • 230 citations

Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus

2005 • 225 citations

The Timing for Neuronal Maturation in the Adult Hippocampus Is Modulated by Local Network Activity

2011 • 217 citations

Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule Cells

2014 • 195 citations

A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity

2015 • 182 citations

Senescent synapses and hippocampal circuit dynamics

2010 • 181 citations

Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus

2006 • 181 citations

Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons

2007 • 168 citations

Altered Hippocampal Transcript Profile Accompanies an Age-Related Spatial Memory Deficit in Mice

2004 • 161 citations

Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits

2016 • 152 citations

GABA Depolarization Is Required for Experience-Dependent Synapse Unsilencing in Adult-Born Neurons

2013 • 149 citations

In VivoAnalysis of Ascl1 Defined Progenitors Reveals Distinct Developmental Dynamics during Adult Neurogenesis and Gliogenesis

2007 • 145 citations

A mechanism for the segregation of age in mammalian neural stem cells

2015 • 144 citations

Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?

2013 • 135 citations

Adult Neurogenesis and the Future of the Rejuvenating Brain Circuits

2015 • 124 citations

Autocrine Action of BDNF on Dendrite Development of Adult-Born Hippocampal Neurons

2015 • 122 citations

A disynaptic feedback network activated by experience promotes the integration of new granule cells

2016 • 120 citations

Mechanisms of Hippocampal Aging and the Potential for Rejuvenation

2017 • 108 citations

Newborn granule cells in the ageing dentate gyrus

2008 • 96 citations

Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle‐age period

2016 • 87 citations

Dynamic role of adult-born dentate granule cells in memory processing

2015 • 67 citations

Aging Research—Where Do We Stand and Where Are We Going?

2014 • 60 citations

Reliable Genetic Labeling of Adult-Born Dentate Granule Cells UsingAscl1^CreERT2andGlast^CreERT2Murine Lines

2015 • 45 citations

Lrig1 is a cell‐intrinsic modulator of hippocampal dendrite complexity and <scp>BDNF</scp> signaling

2016 • 44 citations

Changes in hippocampal neurogenesis throughout early development

2014 • 41 citations

Running-induced memory enhancement correlates with the preservation of thin spines in the hippocampal area CA1 of old C57BL/6 mice

2017 • 22 citations