Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan: Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Cloning and Recombinant Expression of Phospholipase A2 Present in Rheumatoid Arthritic Synovial Fluid

1989 • 542 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

New insights on mammalian phospholipase A ₂ (s); comparison of arachidonoyl‐selective and ‐nonselective enzymes

1993 • 443 citations

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

1990 • 428 citations

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

1991 • 413 citations

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1997 • 311 citations

Regulation of Ras-mediated signalling: more than one way to skin a cat

1995 • 292 citations

Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization.

1994 • 264 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.

1994 • 229 citations

Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.

1983 • 225 citations

Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages.

1996 • 215 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 210 citations

Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.

1993 • 201 citations

Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.

1994 • 162 citations

Regulation of phospholipase A2 activation by phosphorylation in mouse peritoneal macrophages.

1993 • 158 citations

Unsaturated fatty acids as second messengers of superoxide generation by macrophages

1983 • 157 citations

Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.

1988 • 153 citations

Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase.

1994 • 149 citations

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

1994 • 148 citations

Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.

1992 • 141 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists

1996 • 131 citations

Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase

1990 • 129 citations

Tumour necrosis factor-α-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils

1996 • 126 citations

Mapping of the C5a receptor signal transduction network in human neutrophils.

1994 • 124 citations

Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

1993 • 124 citations

The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils

1994 • 124 citations

Human T lymphocyte activation by tumor promoters: role of protein kinase C.

1987 • 106 citations

An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells.

1990 • 104 citations

Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase.

1993 • 104 citations

Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.

1987 • 98 citations

Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2

1988 • 83 citations

5-Lipoxygenase Products Modulate the Activity of the 85-kDa Phospholipase A2 in Human Neutrophils

1995 • 75 citations

The Leukocyte Cell Surface Receptor(s) for the iC3b Product of Complement

1990 • 72 citations

Activation of nadph-oxidase by arachidonic acid involves phospholipase A2 in intact human neutrophils but not in the cell-free system

1986 • 70 citations

Isolation of a human myocardial cytosolic phospholipase A2 isoform. Fast atom bombardment mass spectroscopic and reverse-phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates.

1993 • 67 citations

Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils.

1989 • 66 citations

Immunochemical identification and translocation of protein kinase C zeta in human neutrophils

1994 • 65 citations

Signal transduction pathway in human polymorphonuclear leukocytes for chemotaxis induced by a chemotactic factor. Distinct from the pathway for superoxide anion production.

1994 • 64 citations

Effect of 1,25-dihydroxyvitamin D3, lipopolysaccharide, or lipoteichoic acid on the expression of NADPH oxidase components in cultured human monocytes.

1991 • 60 citations

Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils

1993 • 55 citations

Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor

1994 • 54 citations

Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2

1995 • 53 citations

Role of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages: regulation by Ca2+ and phosphorylation

1995 • 52 citations

Coexistence of two biochemically distinct phospholipase A₂ activities in human platelet, monocyte, and neutrophil

1993 • 49 citations

Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes phosphorylation and an increase in the activity of cytosolic phospholipase A2 in human neutrophils

1996 • 47 citations

Arachidonic acid increases the activity of the assembled NADPH oxidase in cytoplasmic membranes and endosomes

1993 • 46 citations

Protein kinase C isoforms in human neutrophil cytoplasts

1992 • 44 citations

ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.

1990 • 43 citations

Tyrosine Phosphorylation of Phospholipase C-γ2 Is Involved in the Activation of Phosphoinositide Hydrolysis by Fc Receptors in Human Neutrophils

1994 • 42 citations

Stimulation of the respiratory burst in peripheral blood monocytes by lipoteichoic acid. The involvement of calcium ions and phospholipase A2.

1990 • 33 citations

Modulation of the respiratory burst in human neutrophils by isoproterenol and dibutyryl cyclic AMP

1993 • 29 citations

[43] Lysophospholipases I and II from P388D1 macrophage-like cell line

1991 • 26 citations

Activation of cytosolic phospholipase A2 in permeabilized human neutrophils

1996 • 25 citations

The effect of inhibition of both diacylglycerol metabolism and phospholipase A₂ activity on superoxide generation by human neutrophils

1988 • 18 citations

Inhibition of human neutrophil responses by α‐cyano‐3,4‐dihydroxythiocinnamamide; a protein‐tyrosine kinase inhibitor

1992 • 14 citations

Control of motility, exocytosis and the respiratory burst in human neutrophils

1991 • 12 citations

Activation of Phospholipase A2 and Acylation of Lysophospholipids: The Major Regulatiors for Platelet Activating Factor Production in Rat Neutrophils1

1995 • 10 citations

Haematopoietic Defects of W/Wv Mice Studied with the Spleen Colony, Agar Colony, and Diffusion Chamber Techniques

1975 • 7 citations