Associations between morphology, karyotype, and clinical features in myeloid leukemias

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

Important Advances in Oncology: 1986

1986 • 912 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)

1985 • 752 citations

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1983 • 743 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7.

1986 • 704 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Association of an Inversion of Chromosome 16 with Abnormal Marrow Eosinophils in Acute Myelomonocytic Leukemia

1983 • 504 citations

Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease

1981 • 451 citations

Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia

1984 • 441 citations

Distinct haematological disorder with deletion of long arm of No. 5 chromosome

1974 • 432 citations

Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

1973 • 363 citations

Chromosomal banding patterns in acute nonlymphocytic leukemia

1976 • 351 citations

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics

1985 • 331 citations

The 5q− anomaly

1985 • 330 citations

Two human c-onc genes are located on the long arm of chromosome 8.

1982 • 329 citations

All Patients with Acute Nonlymphocytic Leukemia May Have a Chromosomal Defect

1981 • 328 citations

Molecular Basis of Human B Cell Neoplasia

1985 • 316 citations

Acute Promyelocytc Leukemia

1957 • 300 citations

Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome

1985 • 253 citations

8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features

1984 • 248 citations

Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes

1986 • 246 citations

Molecular basis of human B cell neoplasia

1985 • 244 citations

Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association

1983 • 244 citations

Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukemia

1978 • 235 citations

Evidence for the Involvement of GM-CSF and FMS in the Deletion (5q) in Myeloid Disorders

1986 • 233 citations

Acute nonlymphocytic leukemia.A delayed complication of Hodgkin's disease therapy: Analysis of 109 cases

1977 • 227 citations

High-Resolution Chromosomes as an Independent Prognostic Indicator in Adult Acute Nonlymphocytic Leukemia

1984 • 224 citations

Nonrandom Chromosomal Abnormalities in Acute Nonlymphocytic Leukemia in Patients Treated for Hodgkin Disease and Non-Hodgkin Lymphomas

1977 • 219 citations

Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis

1986 • 211 citations

Cancer biology: Heritable fragile sites in cancer

1984 • 210 citations

Hematologic and cytologic characterization of 8/21 translocation acute granulocytic leukemia

1979 • 204 citations

"Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity

1980 • 196 citations

Cytogenetic Studies in 174 Consecutive Patients With Preleukemic or Myelodysplastic Syndromes

1985 • 194 citations

Hu- ets -1 and Hu- ets -2 Genes Are Transposed in Acute Leukemias with (4;11) and (8;21) Translocations

1986 • 191 citations

Chromosomes and causation of human cancer and leukemia.XXVI. Banding studies in acute lymphoblastic leukemia (ALL)

1977 • 188 citations

Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia

1985 • 187 citations

Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q− syndrome

1985 • 180 citations

The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active.

1985 • 177 citations

Identification of the Philadelphia chromosome as a number 22 by quinacrine mustard fluorescence analysis

1970 • 176 citations

Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics

1982 • 171 citations

Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. II. Bone marrow cytology, cytogenetics, results of HLA typing, response to antileukemic chemotherapy, and survival in a total series of 55 patients

1984 • 171 citations

Correlation of Clinical Findings with Quinacrine-Banded Chromosomes in 90 Adults with Acute Nonlymphocytic Leukemia

1978 • 170 citations

Clinical and hematologic characteristics in acute leukemia with 11q23 translocations

1986 • 162 citations

A new hematologic syndrome with a distinct karyotype: the 5 q-- chromosome

1975 • 161 citations

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

1986 • 160 citations

Chromosomal fragile sites and cancer-specific rearrangements

1986 • 160 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 152 citations

Correlation of occupation and karyotype in adults with acute nonlymphocytic leukemia

1982 • 151 citations

Genomic diversity correlates with clinical variation in Ph′-negative chronic myeloid leukaemia

1986 • 145 citations

A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22)

1985 • 141 citations

Clinical and laboratory characteristics of acute leukemia with the 4;11 translocation

1986 • 140 citations

Translocation (9;11)(p21;q23) in three cases of acute monoblastic leukemia

1982 • 140 citations

Acute promyelocytic leukaemia: a study of 39 cases with identification of a hyperbasophilic microgranular variant

1982 • 139 citations

Chromosomal fragile sites and cancer-specific rearrangements

1986 • 132 citations

The Philadelphia Chromosome (Ph¹) in Adults Presenting with Acute Leukaemia: a Comparison of Ph¹+ and Ph¹‐ Patients*

1977 • 131 citations

Therapy-related leukemia. A panmyelosis

1979 • 130 citations

Distinguishing between the Chromosomes involved in Down's Syndrome (Trisomy 21) and Chronic Myeloid Leukaemia (Ph1) by Fluorescence

1971 • 129 citations

Chromosomes and causation of human cancer and leukemia. XI. Correlation of karyotypes with clinical features of acute myeloblastic leukemia

1976 • 125 citations

A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.

1984 • 122 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 118 citations

Four cases of t(4;11) acute leukemia and its myelomonocytic nature in infants

1983 • 117 citations

Chromosome 3 abnormalities in acute nonlymphocytic leukemia (ANLL) with abnormal thrombopoiesis: report of three patients with a "new" inversion anomaly and a further case of homologous translocation

1982 • 115 citations

Fragile sites and predisposition to leukemia and lymphoma

1984 • 115 citations

Monosomy 7 in Childhood: a Myeloproliferative Disorder

1981 • 114 citations

Increased numbers of marrow basophils may be associated with a t(6;9) in ANLL

1985 • 111 citations

Philadelphia chromosome‐negative chronic myelogenous leukaemia: a morphological reassessment

1985 • 109 citations

Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy

1985 • 107 citations

Acute monocytic leukemia chromosome studies

1982 • 106 citations

Human metallothionein genes are clustered on chromosome 16.

1984 • 104 citations

The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.

1986 • 103 citations

Interferon and c- ets -1 Genes in the Translocation (9;11)(p22;q23) in Human Acute Monocytic Leukemia

1986 • 103 citations

Philadelphia chromosome positive childhood acute lymphoblastic leukemia

1980 • 102 citations

Acute nonlymphocytic leukemia in adults: correlations with Q-banded chromosomes

1976 • 102 citations

Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL)

1982 • 101 citations

Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia

1985 • 98 citations

Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblastic leukemia

1982 • 97 citations

Cytogenetic studies on acute monocytic leukemia

1980 • 97 citations

Molecular cloning of the c-fms locus and its assignment to human chromosome 5

1983 • 97 citations

Clinical characteristics and prognosis of 50 patients with a myeloproliferative syndrome and deletion of part of the long arm of chromosome 5

1985 • 93 citations

Clinical implications of aneuploid cyto genetic profiles in adult acute leukemia

1974 • 87 citations

The 5q‐ chromosome abnormality in haematological disorders:|a collaborative study of 34 cases from the Netheralands

1982 • 85 citations

Cytogenetic Studies and Their Clinical Correlates in Adults with Acute Leukemia

1971 • 85 citations

Partial Deletion of Long Arm of Chromosome 17

1976 • 83 citations

Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL)

1982 • 83 citations

Recent Advances in the Biology and Treatment of Acute Lymphoblastic Leukemia in Adults

1984 • 82 citations

Chromosomal Location of Human Metallothionein Genes: Implications for Menkes' Disease

1984 • 76 citations

Chromosomal rearrangements, genes, and fragile sites in cancer: clinical and biologic implications.

1986 • 75 citations

Ph1-Negative Chronic Granulocytic Leukemia: A Nonentity

1986 • 74 citations

Acute myelogenous leukemia and thrombocythemia associated with an abnormality of chromosome No. 3

1979 • 74 citations

Human genes for U2 small nuclear RNA map to a major adenovirus 12 modification site on chromosome 17

1985 • 73 citations

Cytogenetic findings in congenital leukemia: Case report and review of the literature

1983 • 72 citations

Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes

1979 • 69 citations

A Morphologic and Cytochemical Study of Acute Myelomonocytic Leukemia with Abnormal Marrow Eosinophils Associated with Inv(16)(p13q22)

1984 • 66 citations

Abnormalities of chromosome 16 in association with acute myelomonocytic leukemia and dysplastic bone marrow eosinophils.

1984 • 65 citations

Acute nonlymphocytic leukemia in malignant lymphoma.A morphologic study

1978 • 63 citations

Isolation and analysis of the 21q+ chromosome in the acute myelogenous leukemia 8;21 translocation: evidence that c-mos is not translocated.

1985 • 61 citations

Pathogenetic significance of ?pure? monosomy 7 in myeloproliferative disorders. analysis of 14 cases

1982 • 58 citations

Acquired partial deletions of the long arm of chromosome 5 in hematologic disorders

1983 • 56 citations

8/21 Translocation in Acute Myeloid Leukaemia

1981 • 56 citations

Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia

1985 • 54 citations

Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia.

1983 • 53 citations

Comparable complex rearrangements involving 8;21 and 9;22 translocations in leukaemia

1977 • 53 citations

Reciprocal translocation t(6;9)(p21;q33): A new characteristic chromosome anomaly in myeloid leukemias

1983 • 50 citations

[Acute promyelocytic leukemia: a study made on 20 cases].

1959 • 50 citations

Childhood bone marrow monosomy 7 syndrome: A familial disorder?

1985 • 50 citations

3q−, 3q+ anomaly in malignant proliferations in humans

1983 • 49 citations

The Role of the c- mos Gene in the 8;21 Translocation in Human Acute Myeloblastic Leukemia

1985 • 47 citations

A possible specific chromosome marker for monocytic leukemia: Three more patients with t(9;11)(p22;q24) and another with t(11;17)(q24;q21), each with acute monoblastic leukemia

1983 • 47 citations

C‐G translocation in acute myelocytic leukemia with low neutrophil alkaline phosphatase activity

1976 • 46 citations

Cytochemistry of acute promyelocytic leukemia (M3): leukemic promyelocytes exhibit heterogeneous patterns in cellular differentiation

1985 • 46 citations

COMPLEX TKANSLOCATIONS INVOLVING CHROMOSOMES 15 AND 17 IN ACUTE PROMYELOCYTIC LEUKAEMIA

1980 • 45 citations

Acute myeloblastic leukemia (AML) with t(6;9) (p23;q34): A specific subgroup of AML?

1983 • 44 citations

Acute megakaryoblastic leukaemia with 3q inversion and elevated thrombopoietin (TSF): an autocrine role for TSF?

1985 • 42 citations

Partial deletion of long arm of chromosome 17: a specific abnormality in acute promyelocytic leukemia?

1976 • 41 citations

Monosomy 7 and multipotential stem cell transformation

1985 • 40 citations

C-G translocation in acute myelocytic leukemia with low neutrophil alkaline phosphatase activity

1976 • 39 citations

Morphologic and Cytochemical Observations on the Overt Leukemic Phase of Therapy-related Leukemia

1983 • 38 citations

In vivo and in vitro activity of neutrophil alkaline phosphatase in acute myelocytic leukemia with 8;21 translocation

1981 • 38 citations

Translocation (6;9)(p23;q34) in acute nonlymphocytic leukemia

1983 • 37 citations

Cytogenetic findings in the dysmyelopoietic syndrome

1982 • 33 citations

Anomalies of the long arm of chromosome 11 in human myelo- and lymphoproliferative disorders. I. Acute nonlymphocytic leukemia

1983 • 33 citations

Chromosomal localization and characterization of c-abl in the t(6;9) of acute nonlymphocytic leukemia.

1985 • 32 citations

Cytogenetic and ultrastructural features of de novo acute promyelocytic leukemia; The university of Chicago experience (1973–1978)

1979 • 32 citations

Consistent Chromosome Abnormalities in Human Leukemia and Lymphoma

1983 • 31 citations

Chromosomal rearrangements with a common breakpoint at 6p23 in five cases of myeloid leukemia

1983 • 31 citations

Childhood monosomy 7 syndrome

1982 • 30 citations

Chromosomes and causation of human cancer and leukemia. XXXII. Unusual features of Ph1-positive acute myeloblastic leukemia (AML), including a review of the literature

1979 • 30 citations

Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: A subgroup with poor response to therapy

1983 • 28 citations

8;21 chromosome translocation in eosinophilic leukemia

1983 • 28 citations

Akute myelo-monozytäre Leukämie mit atypischen Naphthol-AS-D-Chloracetat-Esterase-positiven Eosinophilen

1970 • 28 citations

Institutional performance in application of the FAB classification of acute leukemia. The southwest oncology group experience

1985 • 28 citations

Significance of a (4; 11) translocation in acute lymphoblastic leukemia

1982 • 27 citations

Cytogenetic and ultrastructural studies on ten patients with acute promyelocytic leukemia, including one case with a complex translocation

1985 • 26 citations

Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia

1986 • 24 citations

Prognosis in Acute Lymphoblastic Leukemia of Childhood as Determined by Cytogenetic Studies at Diagnosis

1983 • 24 citations

The 5q – syndrome: an underdiagnosed form of macrocytic anaemia

1983 • 23 citations

Indications and Limits of Cytochemistry in Acute Leukemia

1973 • 22 citations

Ultrastructural characteristics of therapy-related acute nonlymphocytic leukemia: Evidence for a panmyelosis

1981 • 22 citations

Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias

1973 • 21 citations

Analysis of the breakpoints in translocation (15;17) Observed in 4 patients with acute promyelocytic leukemia

1982 • 20 citations

Cytogenetic characterization of ten cases of Ph1-positive acute myelogenous leukemia

1983 • 20 citations

Congenital leukaemia with 46,XX,t(Bq+,Cq-) cells.

1972 • 20 citations

The 5q – syndrome: an underdiagnosed form of macrocytic anaemia

1983 • 19 citations

Institutional performance in application of the FAB classification of acute leukemia. The southwest oncology group experience

1985 • 19 citations

A variant 15;17 translocation in a patient with acute promyelocytic leukemia

1985 • 17 citations

Morphology and Cytochemistry of “Microgranular” Acute Promyelocytic Leukemia (FAB M3m)

1981 • 15 citations

t(11;19)(q23;p11) in a child with acute T-cell leukemia

1985 • 14 citations

Insertion (10;11)(p11;q23q24) in two cases of acute monocytic leukemia

1985 • 12 citations

Auer Rods in Mature Granulocytes: A Unique Morphologic Feature of Acute Myelogenous Leukemia with Maturation

1984 • 8 citations

COMPARISON OF EOSINOPHILS IN ACUTE NONLYMPHOCYTIC LEUKAEMIA ASSOCIATED WITH THE t(8;21) AND inv(16)

1985 • 6 citations

Critical chromosome rearrangement in acute promyelocytic leukemia

1984 • 5 citations

Acute Myelomonocytic Leukemia (M-4 Subtype) with Abnormal Marrow Eosinophilia and a Normal Chromosome 16

1985 • 3 citations