In vivo adenovirus vector-mediated transfer of the human thrombopoietin cDNA maintains platelet levels during radiation-and chemotherapy- induced bone marrow suppression

Theory and Practice of Histological Techniques

1990 • 6,957 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

1995 • 599 citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

1994 • 460 citations

The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors

1995 • 283 citations

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

1995 • 269 citations

In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells

1994 • 268 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Megakaryocyte growth and development factor ameliorates carboplatin- induced thrombocytopenia in mice

1995 • 206 citations

Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates

1995 • 204 citations

Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice

1995 • 177 citations

Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice

1995 • 162 citations

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1995 • 158 citations

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

1995 • 157 citations

Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.

1995 • 149 citations

Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin

1995 • 130 citations

Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus.

1994 • 121 citations

Structure and Transcription of the Human c-mpl Gene (MPL)

1994 • 105 citations

Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice

1995 • 99 citations

Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes

1995 • 83 citations

Stimulation of erythropoiesis by in vivo gene therapy: physiologic consequences of transfer of the human erythropoietin gene to experimental animals using an adenovirus vector

1994 • 70 citations

Erythropoietin Gene Transfer and Expression in Adult Normal Mice: Use of an Adenovirus Vector

1994 • 35 citations

Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene.

1995 • 26 citations