Hepatic Responses to Bacterial Endotoxin (LPS)

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Endocytosis

1977 • 1,275 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Leukocyte-endothelial interactions

1985 • 834 citations

Hepatogastroenterology

2012 • 832 citations

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

1990 • 828 citations

Endogenous nitric oxide: physiology, pathology and clinical relevance

1991 • 766 citations

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

1990 • 739 citations

Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

1991 • 663 citations

Leukocyte-endothelial interactions

1985 • 635 citations

The Regulation of Hepatic Glutathione

1985 • 615 citations

Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF

1989 • 602 citations

Cells of the hepatic sinusoid

1989 • 589 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

1986 • 551 citations

Secretory products of macrophages and their physiological functions

1984 • 494 citations

Effects of cytokines on the liver

1991 • 409 citations

Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages

1986 • 404 citations

Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.

1987 • 400 citations

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

1990 • 399 citations

Glutathione : metabolism and physiological functions

1990 • 376 citations

The Liver: Biology and Pathology

1989 • 348 citations

Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.

1984 • 334 citations

Molecular mechanisms of signal transduction in macrophages

1987 • 331 citations

Reactive oxygen and ischemia/reperfusion injury of the liver

1991 • 325 citations

Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.

1990 • 322 citations

The Liver: Biology and Pathobiology

1988 • 309 citations

Evaluation of the electroinjection method for introducing proteins into living cells

1991 • 303 citations

Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages

1987 • 300 citations

Leukotriene B4 in inflammation.

1990 • 294 citations

Toxins: Animal, plant and microbial.

1978 • 274 citations

Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock

1971 • 268 citations

In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects.

1991 • 262 citations

Superoxide Generation by Kupffer Cells and Priming of Neutrophils During Reperfusion After Hepatic Ischemia

1991 • 254 citations

Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia

1993 • 252 citations

Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver.

1988 • 237 citations

Metabolism in lymphocytes and its importance in the immune response.

1985 • 228 citations

Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture

1989 • 215 citations

Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats

1992 • 213 citations

Leukocyte‐Cell Adhesion: A Molecular Process Fundamental in Leukocyte Physiology

1990 • 208 citations

Oxygen-derived free radicals promote hepatic injury in the rat

1985 • 207 citations

The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats

1986 • 203 citations

Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes.

1985 • 196 citations

THE PRODUCTION OF TUMOR NECROSIS FACTOR ALPHA AND THE DEVELOPMENT OF A PULMONARY CAPILLARY INJURY FOLLOWING HEPATIC ISCHEMIA/REPERFUSION

1990 • 193 citations

Superoxide Anion Generation in the Liver During the Early Stage of Endotoxemia in Rats

1990 • 192 citations

Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury

1989 • 190 citations

Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1.

1983 • 187 citations

INCREASE IN SURVIVAL TIME OF LIVER TRANSPLANTS BY PROTEASE INHIBITORS AND A CALCIUM CHANNEL BLOCKER, NISOLDIPINE

1990 • 160 citations

The reticuloendothelial system and the pathogenesis of liver disease

1981 • 154 citations

Contribution of different organs to increased glucose consumption after endotoxin administration.

1987 • 152 citations

Involvement of tumor necrosis factor-α in the pathogenesis of activated macrophage-mediated hepatitis in mice

1990 • 128 citations

The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice

1987 • 122 citations

Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication.

1988 • 118 citations

Acute Alcohol Infusion Suppresses Endotoxin‐induced Serum Tumor Necrosis Factor

1989 • 117 citations

Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal Escherichia coli.

1991 • 115 citations

Enhanced expression of group II phospholipase A₂ gene in the tissues of endotoxin shock rats and its suppression by glucocorticoid

1990 • 111 citations

Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury

1991 • 107 citations

Prevention of postischaemic lipid peroxidation and liver cell injury by iron chelation.

1989 • 107 citations

Molecular basis for the enhanced respiratory burst of activated macrophages.

1985 • 104 citations

PAF/cytokine auto-generated feedback networks in microvascular immune injury: consequences in shock, ischemia and graft rejection.

1989 • 100 citations

In vitro toxicity of polymorphonuclear neutrophils to rat hepatocytes: Evidence for a proteinase-mediated mechanism

1988 • 98 citations

Beneficial effects of endotoxins

1984 • 98 citations

Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase

1988 • 97 citations

Interleukin 1: a regulatory role in glucocorticoid-regulated hepatic metabolism.

1986 • 95 citations

Distribution of L- and M-type pyruvate kinase between parenchymal and Kupffer cells of rat liver

1972 • 95 citations

Corynebacterium parvum-elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident kupffer cells in the rat

1986 • 93 citations

Biosynthesis of Lipopolysaccharide-Binding Protein in Rabbit Hepatocytes

1990 • 93 citations

Hypoxic damage generates reactive oxygen species in isolated perfused rat liver

1988 • 86 citations

Glutathione metabolism in resting and phagocytizing peritoneal macrophages.

1982 • 85 citations

Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment.

1991 • 84 citations

Effects of Endotoxin on Gluconeogenesis, Glycogen Synthesis, and Liver Glycogen Synthase in Mice

1973 • 83 citations

Regulation of rabbit acute phase protein biosynthesis by monokines

1988 • 81 citations

Mechanisms of Neutrophil-Mediated Killing of Endothelial Cells

1990 • 80 citations

Regulation of Nitric Oxide Production by Stimulated Rat Kupffer Cells

1991 • 75 citations

Vascular Oxidant Stress and Hepatic Ischemia/Reperfusion Injury

1991 • 75 citations

Glucose utilization by Kupffer cells, endothelial cells, and granulocytes in endotoxemic rat liver

1991 • 69 citations

Isoenzyme patterns in parenchymal and non-parenchymal cells isolated from regenerating and regenerated rat liver

1973 • 68 citations

Macrophage-derived cytokines amplify immune complex-triggered O2-. responses by rat alveolar macrophages.

1988 • 66 citations

Prostaglandin F2α and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor

1988 • 65 citations

Initiation of the respiratory burst in human polymorphonuclear neutrophils: a critical review.

1978 • 65 citations

NADH-Dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: The protective effect of vitamin E

1992 • 63 citations

The pentose phosphate pathway

1986 • 62 citations

Inhibition of ion conductances by osmotic shrinkage of Madin-Darby canine kidney cells

1991 • 61 citations

Plasma catecholamines in the conscious rat during endotoxicosis.

1984 • 60 citations

Glutamine and fatty acid oxidation are the main sources of energy for Kupffer and endothelial cells

1991 • 60 citations

Alterations in Lipogenic Enzymes and Lipoprotein Lipase Activity During Gram-Negative Sepsis in the Rat

1982 • 59 citations

The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations

1987 • 58 citations

Role of leukotriene B4 in the pathogenesis of hepatic ischemia-reperfusion injury in the rat

1992 • 56 citations

Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats

1990 • 56 citations

Tumor necrosis factor-alpha stimulates superoxide anion generation by perfused rat liver and Kupffer cells

1991 • 52 citations

Altered hepatic mitochondrial fatty acid oxidation and ketogenesis in endotoxic rats

1990 • 51 citations

Hormonal and metabolic response to recombinant human tumor necrosis factor in rat: in vitro and in vivo

1988 • 51 citations

Platelet Activating Factor Stimulates and Primes the Liver, Kupffer Cells and Neutrophils to Release Superoxide Anion

1992 • 50 citations

Effect of Bacterial Endotoxins on Carbohydrate Metabolism of Rabbits.

1948 • 47 citations

Time course of changes in gluconeogenesis from various precursors in chronically endotoxemic rats

1985 • 45 citations

Shock, Sepsis, and Organ Failure

1999 • 43 citations

Triacylglycerol kinetics in endotoxic rats with suppressed lipoprotein lipase activity

1987 • 42 citations

Lipid peroxidation is a nonparenchymal cell event with reperfusion after prolonged liver ischemia

1990 • 42 citations

Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion

1987 • 39 citations

The Effect of Aging on Constitutive mRNA Levels and Lipopolysaccharide Inducibility of Acute Phase Genes

1991 • 38 citations

Altered control of carbohydrate metabolism in endotoxemia.

1989 • 38 citations

Interleukin-1 induced increases in glucose utilization are insulin mediated

1989 • 36 citations

In Vivo vs In Vitro Effects of Endotoxin on Glycogenolysis, Gluconeogenesis, and Glucose Utilization

1977 • 36 citations

Altered hepatic vasopressin and alpha 1-adrenergic receptors after chronic endotoxin infusion

1987 • 36 citations

Na-Ca exchange: evidence against a ping-pong mechanism and against a Ca pool in ferret red blood cells

1991 • 36 citations

The binding of Escherichia coli endotoxin to isolated rat hepatocytes

1981 • 36 citations

Molecular and Cellular Mechanisms of Septic Shock

1988 • 35 citations

The role of non-parenchymal cells in liver metabolism

1979 • 35 citations

Selective Stimulation of Epinephrine-Responsive Adenyl Cyclase in Mice by Endotoxin

1971 • 33 citations

Lymphokines and the immune response

1991 • 32 citations

Effects of macrophage colony-stimulating factor and phorbol myristate acetate on 2-<scp>d</scp>-deoxyglucose transport and superoxide production in rat peritoneal macrophages

1991 • 32 citations

Rat liver free cytosolic Ca2+ and glycogen phosphorylase in endotoxicosis and sepsis

1986 • 32 citations

Enhanced phospholipase A2 activity in rat plasma, liver, and intestinal mucosa following endotoxin treatment: A possible explanation for the protective effect of indomethacin in endotoxic shock

1985 • 32 citations

Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver

1992 • 31 citations

Augmented glucose use and pentose cycle activity in hepatic endothelial cells afterin vivo endotoxemia

1993 • 30 citations

Structural changes produced in Kupffer cells in the rat liver by injection of lipopolysaccharide

1988 • 29 citations

Tumor Necrosis Factor Increases In Vivo Glucose Uptake in Hepatic Nonparenchymal Cells

1991 • 28 citations

Lymphokines and the immune response

1990 • 26 citations

Direct Effects of Endotoxin on Hepatocytes

1988 • 25 citations

Eicosanoid Production in Nonparenchymal Liver Cells Isolated From Rats Infused With E. coli Endotoxin

1990 • 24 citations

Correlation between neutrophil superoxide formation, luminol-augmented chemiluminescence and intracellular Ca²⁺levels upon stimulation with leukotriene B₄, formylpeptide and phorbolester

1989 • 23 citations

Uptake and modification of125I-lipopolysaccharide by isolated rat Kupffer cells

1988 • 23 citations

Up-regulation of glucose metabolism in Kupffer cells following infusion of tumour necrosis factor

1991 • 23 citations

Acute effects of interleukin 1α and 6 on intermediary metabolism in freshly isolated rat hepatocytes

1990 • 23 citations

Stimulation of phosphatidylinositol turnover in the macrophage plasma membrane: a possible mechanism for signal transmission.

1979 • 23 citations

Interleukin 1-like factors can accumulate 5-hydroxytryptamine in the liver of mice and can induce hypoglycaemia

1985 • 23 citations

The contribution of gluconeogenesis to glycogen repletion during glucose infusion in endotoxemia

1987 • 22 citations

Prostaglandin F2α stimulates gluconeogenesis in the perfused rat liver and this effect is blunted in livers from endotoxin infused rats

1990 • 22 citations

IP3-dependent Ca2+ release in permeabilized hepatocytes of endotoxemic and septic rats

1987 • 21 citations

In vivo latex phagocytosis primes the Kupffer cells and hepatic neutrophils to generate superoxide anion

1992 • 21 citations

In vitro and in vivo effect of Escherichia coli endotoxin on mitochondrial phospholipase A₂ activity

1981 • 20 citations

Effect of Acute Alcohol Administration on TNF‐α Binding to Neutrophils and Isolated Liver Plasma Membranes

1992 • 19 citations

Platelet-activating factor-induced increases in glucose kinetics

1988 • 16 citations

Glycolytic and tricarboxylic acid cycle intermediates in dog livers during endotoxic shock

1985 • 15 citations

Metabolic fate of arachidonic acid in hepatocytes of continuously endotoxemic rats.

1988 • 15 citations

Endotoxin-induced inhibition of steroid binding by mouse liver cytosol.

1982 • 15 citations

In vivo metabolic response of hepatic nonparenchymal cells and leukocytes to granulocyte-macrophage colony-stimulating factor

1992 • 14 citations

Further characterization of a model of chronic endotoxemia in the rat: adenine nucleotide content in liver.

1988 • 11 citations

Distribution of Lactate Dehydrogenase Isozymes in Rat Liver Cells

1973 • 9 citations

Endotoxin increases the liver fructose 2,6-bisphosphate concentration in fasted rats

1989 • 9 citations

Down-regulation of prostaglandin F2α receptors in rat liver during chronic endotoxemia

1991 • 8 citations

Perturbation of glycerolipid content and biosynthesis in hepatocytes of rats continuously infused with Escherichia coli endotoxin

1988 • 8 citations

Effects of Acute and Chronic Endotoxin Treatment on Glucagon and Insulin Receptors on Rat Liver Plasma Membranes

1982 • 8 citations

Effect of bacterial endotoxin on plasma concentration of haptoglobin and fibrinogen in rats treated with metopyrone

1990 • 8 citations

Regulation of insulin and interleukin-1 release after Propionibacterium acnes-induced macrophage activation in mice.

1989 • 8 citations

Alterations in binding of inositol 1,4,5-trisphosphate to subcellular structures of rat liver during chronic endotoxemia

1989 • 8 citations

Fate of 3H-labeled endotoxin in partially hepatectomised rats.

1988 • 7 citations

Effect of LPS on Carbohydrate and Lipid Metabolism

1983 • 6 citations

Inositol lipid metabolism in vasopressin stimulated hepatocytes from rats infused with tumor necrosis factor

1989 • 6 citations

Triacylglycerol output by the isolated perfused liver of endotoxin-treated rats.

1988 • 4 citations

Cytokines et régulation du métabolisme glucidique lors de l'infection

1990 • 4 citations

Protein phosphorylation in isolated hepatocytes of septic and endotoxemic rats

1989 • 4 citations

Inhibition of granulocyte-mediated release of oxygen free radicals following glutathione depletion

1988 • 3 citations

Endotoxin, epinephrine, glucagon, insulin and calcium ionophore A23187 modulation of pyruvate kinase activity in cultured rat hepatocytes.

1990 • 2 citations

PHARMACOLOGIC REVERSAL OF SELECTED EFFECTS OF ENDOTOXIN

1978 • 2 citations

Biochemical and metabolic response to nitrogen dioxide-induced endothelial injury.

1987 • 1 citations

Increased Glucose Uptake and Superoxide Anion Production after Priming or Activation of Hepatic Phagocytes: A Potential Source of Liver Damage

1991 • 1 citations