Prolyl Isomerases: Role in Protein Folding

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Protein Folding

1992 • 1,601 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

Influence of proline residues on protein conformation

1991 • 1,125 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

1991 • 882 citations

Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfolded state depends on two chaperonin proteins and Mg-ATP

1989 • 737 citations

Folding and association of proteins

1987 • 697 citations

Occurrence and role ofcis peptide bonds in protein structures

1990 • 516 citations

Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay

1991 • 506 citations

Catalysis of protein folding by prolyl isomerase

1987 • 488 citations

GroE facilitates refolding of citrate synthase by suppressing aggregation

1991 • 486 citations

Transient folding intermediates characterized by protein engineering

1990 • 446 citations

Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.

1988 • 445 citations

Protein folding: local structures, domains, subunits, and assemblies

1991 • 432 citations

Conformational stability of globular proteins

1990 • 390 citations

Nmr studies of the rates of proline cis–trans isomerization in oligopeptides

1981 • 368 citations

pH dependence of the urea and guanidine hydrochloride denaturation of ribonuclease A and ribonuclease T1

1990 • 331 citations

The cyclophilin homolog ninaA is required in the secretory pathway

1991 • 330 citations

Defective co-translational formation of disulphide bonds in protein disulphide-isomerase-deficient microsomes

1988 • 330 citations

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

1991 • 319 citations

Cyclosporin A slows collagen triple-helix formation in vivo: indirect evidence for a physiologic role of peptidyl-prolyl cis-trans-isomerase.

1991 • 313 citations

Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

1990 • 303 citations

Native disulphide bond formation in protein biosynthesis: evidence for the role of protein disulphide isomerase

1984 • 293 citations

The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein

1989 • 288 citations

Specific protein-nucleic acid recognition in ribonuclease T1–2′-guanylic acid complex: an X-ray study

1982 • 272 citations

The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins

1991 • 271 citations

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

1991 • 270 citations

The X‐Pro peptide bond as an nmr probe for conformational studies of flexible linear peptides

1976 • 270 citations

Complementary DNA for human T-cell cyclophilin.

1987 • 268 citations

Folding Mechanism of the Triple Helix in Type‐III Collagen and Type‐III pN–Collagen

1980 • 264 citations

The Zipper-Like Folding Of Collagen Triple Helices And The Effects Of Mutations That Disrupt The Zipper

1991 • 262 citations

Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.

1990 • 237 citations

Acid catalysis of the formation of the slow-folding species of RNase A: Evidence that the reaction is proline isomerization

1978 • 229 citations

Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding

1991 • 204 citations

Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein).

1989 • 202 citations

Catalysis of protein folding by cyclophilins from different species

1991 • 183 citations

Conformation states of concanavalin A: Kinetics of transitions induced by interaction with Mn²⁺ and Ca²⁺

1977 • 176 citations

Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum

1991 • 168 citations

Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis

1987 • 167 citations

The influence of peptidyl-prolyl cis-trans isomerase on the in vitro folding of type III collagen.

1987 • 165 citations

Role of proline isomerization in folding of ribonuclease A at low temperatures

1979 • 161 citations

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

1990 • 160 citations

Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells

1991 • 159 citations

Both the Fast and Slow Refolding Reactions of Ribonuclease A Yield Native Enzyme

1973 • 157 citations

Effect of proline residues on protein folding

1981 • 155 citations

Kinetic coupling between protein folding and prolyl isomerization

1992 • 154 citations

Folding of ribonuclease T1. 1. Existence of multiple unfolded states created by proline isomerization

1990 • 150 citations

Ribonuclease T1: Structure, Function, and Stability

1991 • 148 citations

Folding of ribonuclease T1. 2. Kinetic models for the folding and unfolding reactions

1990 • 141 citations

Cis‐Trans equilibrium and kinetic studies of acetyl‐<scp>L</scp>‐proline and glycyl‐<scp>L</scp>‐proline

1977 • 138 citations

A novel secreted cyclophilin-like protein (SCYLP)

1991 • 138 citations

Test of the extended two-state model for the kinetic intermediates observed in the folding transition of ribonuclease A

1978 • 137 citations

The Role of Cis-Trans Isomerization of Peptide Bonds in the Coil Triple Helix Conversion of Collagen

1978 • 134 citations

Nmr studies of the molecular conformations in the linear oligopeptides H‐(<scp>L</scp>‐Ala)_n‐<scp>L</scp>‐Pro‐OH

1976 • 129 citations

Replacement of a cis proline simplifies the mechanism of ribonuclease T1 folding

1990 • 129 citations

Unfolding and refolding of the constant fragment of the immunoglobulin light chain

1982 • 124 citations

An endoplasmic reticulum-specific cyclophilin.

1991 • 124 citations

Proline isomerism leads to multiple folded conformations of calbindin D9k: direct evidence from two-dimensional 1H NMR spectroscopy.

1989 • 119 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 118 citations

Ribonuclease T1 is stabilized by cation and anion binding

1988 • 115 citations

The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase

1985 • 113 citations

Comparison of the activities of protein disulphide-isomerase and thioredoxin in catalysing disulphide isomerization in a protein substrate

1991 • 111 citations

Formation of the Triple Helix of Type I Procollagen in cellulo. A Kinetic Model Based on cis-trans Isomerization of Peptide Bonds

1981 • 105 citations

Replacement of proline-76 with alanine eliminates the slowest kinetic phase in thioredoxin folding

1987 • 98 citations

Three-dimensional structure of ribonuclease T1 complexed with guanylyl-2′,5′-guanosine at 1.8 Å resolution

1989 • 95 citations

Kinetic coupling between protein folding and prolyl isomerization

1992 • 95 citations

S-cyclophilin. New member of the cyclophilin family associated with the secretory pathway

1991 • 92 citations

Peptidyl-prolyl cis-trans isomerase improves the efficiency of protein disulfide isomerase as a catalyst of protein folding.

1992 • 91 citations

Thermal Stability and Folding of Type IV Procollagen and Effect of Peptidyl-Prolyl cis-trans-Isomerase on the Folding of the Triple Helix

1989 • 90 citations

Unfolding and refolding occur much faster for a proline-free proteins than for most proline-containing proteins.

1977 • 88 citations

Spectral evidence for a rapidly formed structural intermediate in the refolding kinetics of hen egg-white lysozyme

1981 • 87 citations

Role of proline peptide bond isomerization in unfolding and refolding of ribonuclease.

1986 • 85 citations

Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli

1989 • 76 citations

Catalysis of proline isomerization during protein-folding reactions

1988 • 73 citations

The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration

1979 • 71 citations

Further evidence suggesting that the slow phase in protein unfolding and refolding is due to proline isomerization: a kinetic study of carp parvalbumins

1978 • 68 citations

Protein secondary structure determination by NMR Application with recombinant human cyclophilin

1991 • 66 citations

Nature of the fast and slow refolding reactions of iron(III) cytochrome c

1981 • 65 citations

Identification and characterization of the direct folding process of hen egg-white lysozyme

1982 • 65 citations

Intermediates in the chaperonin-assisted refolding of rhodanese are trapped at low temperature and show a small stoichiometry.

1991 • 65 citations

The rate and structural consequences of proline cis-trans isomerization in calbindin D9k: NMR studies of the minor (cis-Pro43) isoform and the Pro43Gly mutant

1990 • 65 citations

Folding of homologous proteins

1983 • 65 citations

The disulphide folding pathway of ribonuclease T1

1986 • 65 citations

Formation of the triple helix of type I procollagen in cellulo. Temperature-dependent kinetics support a model based on cis trans isomerization of peptide bonds

1984 • 62 citations

The nature of the slow metal ion-dependent conformational transition in bovine prothrombin

1979 • 58 citations

Conformational transitions of thioredoxin in guanidine hydrochloride

1984 • 56 citations

Kinetic analysis of the reversible folding reactions of small proteins: Application to the folding of lysozyme and cytochrome c

1977 • 56 citations

Enzymic catalysis of prolyl isomerization in an unfolding protein

1992 • 54 citations

Coupling between local structure and global stability of a protein: mutants of staphylococcal nuclease

1990 • 54 citations

Effects of proline mutations on the unfolding and refolding of human lysozyme: the slow refolding kinetic phase does not result from proline cis-trans isomerization

1991 • 49 citations

Hydrogen-1 NMR evidence for three interconverting forms of staphylococcal nuclease: effects of mutations and solution conditions on their distribution

1989 • 48 citations

Folding of RNase T1 is decelerated by a specific tertiary contact in a folding intermediate

1992 • 47 citations

The Pro¹¹⁷ to glycine mutation of staphylococcal nuclease simplifies the unfolding—folding kinetics

1991 • 42 citations

Guanidine hydrochloride-induced equilibrium unfolding of mutant forms of iso-1-cytochrome c with replacement of proline-71

1986 • 39 citations

Effects of guanidine hydrochloride on the refolding kinetics of denatured thioredoxin

1986 • 39 citations

Stability of recombinant Lys25-ribonuclease T1

1990 • 38 citations

Mechanism of renaturation of a large protein, aspartokinase-homoserine dehydrogenase

1987 • 37 citations

Native-like folding intermediates of homologous ribonucleases

1985 • 34 citations

Proline Isomerization in Unfolded Ribonuclease A

2005 • 34 citations

Changes in conformation and slow refolding kinetics in mutant iso-2-cytochrome c with replacement of a conserved proline residue

1987 • 27 citations

Folding mechanism of porcine ribonuclease

1986 • 25 citations

Construction and characterization of mutant iso-2-cytochromes c with replacement of conserved prolines

1988 • 21 citations

Role of two proline-containing turns in the folding of porcine ribonuclease

1990 • 20 citations

An examination of the involvement of proline peptide isomerization in protein folding

1978 • 20 citations

Peptidyl‐prolyl cis‐trans isomerase does not affect the Pro‐43 cis‐trans isomerization rate in folded calbindin D_9k

1990 • 20 citations

Nonnative isomers of proline-93 and -114 predominate in heat-unfolded ribonuclease A

1990 • 19 citations

Isolation and functional reconstitution of soluble melibiose permease from Escherichia coli

1990 • 19 citations

Conformational relaxations of urea- and guanidine hydrochloride-unfolded ferricytochrome c.

1977 • 14 citations

Confirmation of the predicted source of a slow folding reaction: proline 8 of bovine pancreatic trypsin inhibitor

1991 • 13 citations

Energy difference associated with proline isomerization in ribonuclease A

1985 • 10 citations