Signal Transduction in Ischemic Preconditioning:

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

1991 • 1,346 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.

1992 • 961 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Mitochondrial ATP-Dependent Potassium Channels

1998 • 825 citations

Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells

1998 • 820 citations

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

1997 • 704 citations

Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features.

1990 • 605 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 584 citations

Toward Understanding the Assembly and Structure of K_ATPChannels

1998 • 543 citations

Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

1995 • 524 citations

“Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium

1998 • 510 citations

Meeting Highlights

1996 • 497 citations

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

1997 • 491 citations

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

1997 • 490 citations

Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker.

1994 • 476 citations

Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction.

1992 • 457 citations

Protein kinase C isozymes and substrates

1996 • 440 citations

Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C

1995 • 424 citations

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

1995 • 397 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Morphine Mimics the Cardioprotective Effect of Ischemic Preconditioning via a Glibenclamide-Sensitive Mechanism in the Rat Heart

1996 • 373 citations

Protein kinase C. Its role in ischemic preconditioning in the rat.

1994 • 362 citations

Ischemic preconditioning protects against infarction in rat heart

1992 • 357 citations

Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes

1997 • 345 citations

Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias

1987 • 339 citations

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses

1998 • 320 citations

Evidence that Translocation of Protein Kinase C is a Key Event During Ischemic Preconditioning of Rabbit Myocardium

1994 • 310 citations

Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K ⁺ Channel?

1995 • 293 citations

Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs

1993 • 291 citations

Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate

1992 • 282 citations

Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart

1994 • 272 citations

Phosphorylation of Tyrosine 182 of p38 Mitogen-activated Protein Kinase Correlates with the Protection of Preconditioning in the Rabbit Heart

1997 • 270 citations

Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs.

1994 • 259 citations

alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.

1994 • 258 citations

Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts

1996 • 251 citations

Improved myocardial ischemic response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: A prospective study

1992 • 250 citations

Preconditioning of Human Myocardium With Adenosine During Coronary Angioplasty

1997 • 250 citations

Preconditioning of the ischaemic myocardium; involvement of the <scp>l</scp>‐arginine nitric oxide pathway

1992 • 238 citations

The p38‐MAPK inhibitor, SB203580, inhibits cardiac stress‐activated protein kinases/c‐Jun N‐terminal kinases (SAPKs/JNKs)

1998 • 224 citations

Cation transport in mitochondria — The potassium cycle

1996 • 208 citations

Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine

1994 • 197 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 194 citations

Reduction of infarct size by oxygen inhalation following acute coronary occlusion.

1975 • 188 citations

Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts

1995 • 180 citations

Selective Activation of A ₃ Adenosine Receptors With N ⁶ -(3-Iodobenzyl)Adenosine-5′- N -Methyluronamide Protects Against Myocardial Stunning and Infarction Without Hemodynamic Changes in Conscious Rabbits

1997 • 171 citations

Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning.

1994 • 163 citations

Intracellular signalling through protein kinases in the heart

1995 • 163 citations

Prevention of Ischemic Preconditioning Only by Combined Inhibition of Protein Kinase C and Protein Tyrosine Kinase in Pigs

1998 • 157 citations

Preconditioning in isolated superfused human muscle

1995 • 157 citations

Protein Tyrosine Kinase is Downstream of Protein Kinase C for Ischemic Preconditioning's Anti-infarct Effect in the Rabbit Heart

1998 • 154 citations

Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.

1993 • 153 citations

Cardioprotection with the KATP Opener Cromakalim Is Not Correlated with Ischemic Myocardial Action Potential Duration

1995 • 148 citations

Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.

1991 • 140 citations

Infarct size-limiting effect of ischemic preconditioning is blunted by inhibition of 5'-nucleotidase activity and attenuation of adenosine release.

1994 • 137 citations

Isolation of plasma membrane fractions from the intestinal epithelial model T84

1993 • 134 citations

Ischemic Preconditioning: Bioenergetic and Metabolic Changes and the Role of Endogenous Adenosine

1996 • 134 citations

Untitled

1998 • 125 citations

The Ischemia-selective KATPChannel Antagonist, 5-Hydroxydecanoate, Blocks Ischemic Preconditioning in the Rat Heart

1997 • 124 citations

Involvement of Protein Kinase C and Src Family Tyrosine Kinase in Gαq/11-induced Activation of c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase

1998 • 124 citations

Role of Activation of Protein Kinase C in the Infarct SizeLimiting Effect of Ischemic Preconditioning Through Activation of Ecto-5′-nucleotidase

1996 • 122 citations

Does Ischemic Preconditioning Trigger Translocation of Protein Kinase C in the Canine Model?

1995 • 122 citations

Involvement of endogenous adenosine in ischaemic preconditioning in swine

1995 • 121 citations

Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

1997 • 110 citations

Pharmacology of ATP-sensitive potassium channel (K&lt;SUB&gt;ATP&lt;/SUB&gt;) openers in models of myocardial ischemia and reperfusion

1997 • 110 citations

Infarct limitation of the second window of protection in a conscious rabbit model

1996 • 108 citations

No Prevention of Ischemic Preconditioning by the Protein Kinase C Inhibitor Staurosporine in Swine

1996 • 103 citations

Mammalian Mitogen-activated Protein Kinase Pathways Are Regulated through Formation of Specific Kinase-Activator Complexes

1996 • 103 citations

Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli

1998 • 100 citations

Effect of practolol on the extent of myocardial ischaemic injury after experimental coronary occlusion and its effects on ventricular function in the normal and ischaemic heart

1973 • 99 citations

Phosphotyrosine-Dependent Targeting of Mitogen-Activated Protein Kinase in Differentiated Contractile Vascular Cells

1995 • 94 citations

Potassium channels and preconditioning of isolated rabbit cardiomyocytes: Effects of glyburide and pinacidil

1995 • 93 citations

Pretreatment with Endothelin-1 Mimics Ischemic Preconditioning Against Infarction in Isolated Rabbit Heart

1996 • 91 citations

Signal Transduction in Ischemic Preconditioning

1997 • 90 citations

Protection of Ischemic Preconditioning is Dependent upon a Critical Timing Sequence of Protein Kinase C Activation

1997 • 87 citations

Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation

1993 • 76 citations

Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate

1996 • 75 citations

Preconditioning cultured human pediatric myocytes requires adenosine and protein kinase C

1997 • 74 citations

Ketamine-xylazine anaesthesia permits a KATPchannel antagonist to attenuate preconditioning in rabbit myocardium

1994 • 74 citations

Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening

1995 • 73 citations

Reduction in Myocardial Infarct Size by Basic Fibroblast Growth Factor After Temporary Coronary Occlusion in a Canine Model

1996 • 71 citations

The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning

1992 • 66 citations

Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1

1998 • 66 citations

Intracellular signalling through protein kinases in the heart

1995 • 62 citations

Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit

1995 • 58 citations

Pharmacology of ATP-sensitive potassium channel (K_ATP) openers in models of myocardial ischemia and reperfusion

1997 • 55 citations

Translocation of PKC, Protein Phosphatase Inhibition and Preconditioning of Rabbit Cardiomyocytes

1996 • 51 citations

Electrophysiological Characteristics of Repetitive Ischemic Preconditioning in the Pig Heart

1996 • 50 citations

Differential Activation of Mitogen-activated Protein Kinase and S6 Kinase Signaling Pathways by 12-O-Tetradecanoylphorbol-13-acetate (TPA) and Insulin

1995 • 49 citations

Myosin Light Chain Phosphorylation in Cardiac Hypertrophy and Failure due to Myocardial Infarction

1995 • 46 citations

Insulin-like growth factor-II delays myocardial infarction in experimental coronary artery occlusion

1997 • 46 citations

Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol

1993 • 42 citations

Attenuated Purine Production During Subsequent Ischemia in Preconditioned Rabbit Myocardium is Unrelated to the Mechanism of Protection

1996 • 41 citations

The PKC Activator PMA Preconditions Rabbit Heart in the Presence of Adenosine Receptor Blockade: Is 5′-Nucleotidase Important?

1998 • 41 citations

Adenosine deaminase inhibition augments interstitial adenosine but does not attenuate myocardial infarction

1995 • 40 citations

A Metabolic Sensor in Action: News From the ATP-Sensitive K+-Channel

1997 • 35 citations

Attenuation of S-T Segment elevation during repetitive coronary occlusions truly reflects the protection of Ischemic preconditioning and is not an epiphenomenon

1997 • 34 citations

Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase C?, but not p42/44MAPK

1996 • 30 citations

Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening

1995 • 28 citations

Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit

1995 • 25 citations

Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate

1996 • 22 citations

Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.

1995 • 17 citations

Adenosine deaminase inhibition augments interstitial adenosine but does not attenuate myocardial infarction

1995 • 9 citations

Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells

1995 • 5 citations

AFGF induced cardioprotection in ischemic myocardium can be antagonized by Suramin

1996 • 2 citations