No Prevention of Ischemic Preconditioning by the Protein Kinase C Inhibitor Staurosporine in Swine

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

1991 • 1,346 citations

The collateral circulation of the heart

1988 • 607 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Ischemic preconditioning reduces infarct size in swine myocardium.

1990 • 560 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

1995 • 524 citations

Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C

1995 • 424 citations

Measurement of regional myocardial blood flow with multiple colored microspheres.

1991 • 387 citations

Protein kinase C. Its role in ischemic preconditioning in the rat.

1994 • 362 citations

Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts

1995 • 317 citations

Regional Myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine.

1976 • 310 citations

Evidence that Translocation of Protein Kinase C is a Key Event During Ischemic Preconditioning of Rabbit Myocardium

1994 • 310 citations

Development of short-term myocardial hibernation. Its limitation by the severity of ischemia and inotropic stimulation.

1993 • 302 citations

Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K ⁺ Channel?

1995 • 293 citations

Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs

1993 • 291 citations

Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes

1994 • 280 citations

alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.

1994 • 258 citations

Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors.

1992 • 255 citations

Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.

1993 • 252 citations

Role of bradykinin in myocardial preconditioning.

1994 • 231 citations

Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine

1994 • 197 citations

Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts

1995 • 180 citations

Synergistic Modulation of ATP-Sensitive K ⁺ Currents by Protein Kinase C and Adenosine

1996 • 175 citations

Pretreatment with Pertussis Toxin Blocks the Protective Effects of Preconditioning: Evidence for a G-protein Mechanism

1993 • 175 citations

Characterization of specific binding sites for [3H]-staurosporine on various protein kinases

1990 • 164 citations

Intracellular signalling through protein kinases in the heart

1995 • 163 citations

Protein Kinase C Activates ATP-Sensitive K ⁺ Current in Human and Rabbit Ventricular Myocytes

1996 • 162 citations

Cardioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel

1994 • 158 citations

Protein kinase C isoform diversity in the heart

1995 • 146 citations

Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs.

1993 • 134 citations

Isolation of plasma membrane fractions from the intestinal epithelial model T84

1993 • 134 citations

Role of Activation of Protein Kinase C in the Infarct SizeLimiting Effect of Ischemic Preconditioning Through Activation of Ecto-5′-nucleotidase

1996 • 122 citations

Does Ischemic Preconditioning Trigger Translocation of Protein Kinase C in the Canine Model?

1995 • 122 citations

Alpha 1-adrenoceptor activation mediates the infarct size-limiting effect of ischemic preconditioning through augmentation of 5'-nucleotidase activity.

1994 • 121 citations

Involvement of endogenous adenosine in ischaemic preconditioning in swine

1995 • 121 citations

Calcium Responsiveness in Regional Myocardial Short-term Hibernation and Stunning in the In Situ Porcine Heart

1996 • 108 citations

Consequences of regional inotropic stimulation of ischemic myocardium on regional myocardial blood flow and function in anesthetized swine.

1989 • 81 citations

Does protein kinase C play a role in ischemic preconditioning in rat hearts?

1995 • 79 citations

Protein Kinase Inhibitors: Probes for the Functions of Protein Phosphorylation

1991 • 76 citations

Use of a PCR-based method to characterize protein kinase C isoform expression in cardiac cells

1993 • 70 citations

Intraischemic Preconditioning

1995 • 68 citations

Limitation of myocardial infarct size by adenosine A1 receptor activation is abolished by protein kinase C inhibitors in the rabbit

1995 • 58 citations

Characterization of specific [3H]dimethylstaurosporine binding to protein kinase C

1990 • 34 citations

Protein kinase inhibitors and blood pressure control in spontaneously hypertensive rats.

1991 • 32 citations

CORDAT II: A new program for data acquisition and on-line calculation of hemodynamic and regional myocardial dimension parameters

1993 • 27 citations

Hemodynamic and Renal Effects of the Protein Kinase Inhibitor Staurosporine in Conscious Rats

1992 • 6 citations