Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes

1992 • 133 citations

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.

1992 • 111 citations

The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.

1992 • 99 citations

Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.

1993 • 90 citations

Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.

1991 • 88 citations

Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.

1994 • 87 citations

Characterization of a 60-kilodalton substrate of the insulin receptor kinase

1994 • 80 citations

Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.

1994 • 78 citations

Insulin Action in Normal and Protein Kinase C-Deficient Rat Hepatoma Cells. Effects on Protein Phosphorylation, Protein Kinase Activities, and Ornithine Decarboxylase Activities and Messenger Ribonucleic Acid Levels*

1987 • 60 citations

Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation.

1992 • 49 citations

Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal growth factor receptor.

1993 • 33 citations

Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.

1992 • 29 citations

Mutation of Amino Acids in pp60^c-src That Are Phosphorylated by Protein Kinases C and A

1989 • 24 citations

Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction.

1994 • 22 citations

Quantitative analysis of SH2 domain binding. Evidence for specificity and competition.

1992 • 21 citations

Direct evidence for protein kinase c involvement in insulin-stimulated hexose uptake

1992 • 16 citations