P-glycoprotein (P-gp/MDR1)-Mediated Efflux of Sex-Steroid Hormones and Modulation of P-gp Expression In Vitro

Goodman & Gilman's The Pharmacological Basis of Therapeutics

1985 • 7,054 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

P-glycoprotein and multidrug resistance

1996 • 549 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Penetration of Endogenous Steroid Hormones Corticosterone, Cortisol, Aldosterone and Progesterone into the Brain is Enhanced in Mice Deficient for Both mdr1a and mdr1b P‐Glycoproteins

2002 • 207 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

1989 • 179 citations

Steroid Transport, Accumulation, and Antagonism of P-Glycoprotein in Multidrug-Resistant Cells

1996 • 154 citations

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1993 • 138 citations

Functional Analysis of a Novel Estrogen Receptor-β Isoform

1999 • 131 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

2001 • 94 citations

Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′‐hydroxylation

2000 • 78 citations

Steroid hormones inhibit binding of alkaloid to multidrug resistance related P-glycoprotein

1989 • 74 citations

Progesterone regulates the murine multidrug resistance mdr1b gene.

1993 • 73 citations

Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.

1993 • 65 citations

Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein.

1988 • 61 citations

Modulation of P-glycoprotein activity in Calu-3 cells using steroids and β-ligands

2001 • 60 citations

P-glycoprotein expression is increased in human secretory and gestational endometrium.

1991 • 56 citations

Expression and Functions of P‐glycoprotein (mdr 1 gene product) in Normal and Malignant Tissues

1990 • 53 citations

Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells.

2002 • 51 citations

A pharmacokinetic study with a low-dose oral contraceptive containing 20 μg ethinylestradiol plus 100 μg levonorgestrel

2002 • 45 citations

Different Absorption Behaviors among Steriod Hormones Due to Possible Interaction with P-Glycoprotein in the Rat Small Intestine.

1999 • 42 citations

Factors affecting the enterohepatic circulation of oral contraceptive steroids

1990 • 34 citations

Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland

1993 • 32 citations

The Effect of Food on the Bioavailability of Norethindrone and Ethinyl Estradiol from Norethindrone Acetate/Ethinyl Estradiol Tablets Intended for Continuous Hormone Replacement Therapy

2003 • 28 citations

Preliminary Evaluation of Progestins as Inducers of Cytochrome P450 3A4 Activity in Postmenopausal Women

1998 • 22 citations

Comparative measurements of serum estriol, estradiol, and estrone in non-pregnant, premenopausal women; a preliminary investigation.

1999 • 21 citations

The induction of multidrug resistance in human cervical carcinoma cell lines by estrogenic hormones.

1994 • 15 citations

Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein

2002 • 12 citations