Cytochrome P450: A Target for Drug Development for Skin Diseases

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Pigments of rat liver microsomes

1958 • 634 citations

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

1994 • 503 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

Pigments of rat liver microsomes

2002 • 416 citations

Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase

1996 • 376 citations

Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues: Differential inhibition and stimulation by benzoflavones and organic solvents

1971 • 374 citations

Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)

2003 • 283 citations

The Regulation of Cytochrome P-450 Gene Expression

1986 • 283 citations

Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes

1955 • 255 citations

Leukotrienes and Other Lipoxygenase Products in the Pathogenesis and Therapy of Psoriasis and Other Dermatoses

1983 • 227 citations

Expression of Multiple Cytochrome P450 Enzymes and Multidrug Resistance-Associated Transport Proteins in Human Skin Keratinocytes

2001 • 218 citations

A Novel Human Cytochrome P450, CYP26C1, Involved in Metabolism of 9-cis and All-trans Isomers of Retinoic Acid

2003 • 212 citations

Voriconazole

2003 • 202 citations

Production of Intraepidermal Microabscesses by Topical Application of Leukotriene B4

1984 • 187 citations

Retinoids and cell differentiation

1986 • 187 citations

Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal.

1992 • 161 citations

Eicosanoids in skin of patients with atopic dermatitis: Prostaglandin E and leukotriene B are present in biologically active concentrations

1989 • 149 citations

Ultraviolet-B Exposure of Human Skin Induces Cytochromes P450 1A1 and 1B1

2000 • 146 citations

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases

2003 • 142 citations

Stereoisomers of ketoconazole: preparation and biological activity

1992 • 130 citations

Metabolism of all-trans-retinoic acid in hamster liver microsomes: Oxidation of 4-hydroxy- to 4-keto-retinoic acid

1980 • 127 citations

Metabolism of retinoic acid and retinol during differentiation of F9 embryonal carcinoma cells.

1985 • 127 citations

Oral liarozole in the treatment of palmoplantar pustular psoriasis: a randomized, double-blind, placebo-controlled study

2001 • 110 citations

R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents.

2000 • 107 citations

Quantitation of cytochrome P450 mRNA levels in human skin

2003 • 96 citations

RESPONSE OF SCALP PSORIASIS TO ORAL KETOCONAZOLE

1985 • 94 citations

Is there a case for P-450 inhibitors in cancer treatment?

1989 • 88 citations

Induction of Benzo[α]pyrene Hydroxylase in Human Skin

1972 • 88 citations

Drug metabolism in skin. Comparative activity of the mixed-function oxidases, epoxide hydratase, and glutathione S-transferase in liver and skin of the neonatal rat.

1981 • 86 citations

A Systematic Review of Adverse Effects Associated with Topical Treatments for Psoriasis

2003 • 85 citations

Multiple Cytochrome P450 Isozymes in Murine Skin: Induction of P450 1A, 2B, 2E, and 3A by Dexamethasone

1994 • 80 citations

Peroxidative reactions of diversozymes ¹

1996 • 78 citations

Participation of P450 3A Enzymes in Rat Hepatic Microsomal Retinoic Acid 4-Hydroxylation

1993 • 72 citations

Inhibition of polycyclic aromatic hydrocarbon-DNA adduct formation in epidermis and lungs of SENCAR mice by naturally occurring plant phenols.

1987 • 72 citations

Inducibility of benzo [α] pyrene hydroxylase in human skin by polycyclic hydrocarbons

1973 • 70 citations

A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.

1989 • 69 citations

EFFECTS OF HIGH DOSE KETOCONAZOLE THERAPY ON THE MAIN PLASMA TESTICULAR AND ADRENAL STEROIDS IN PREVIOUSLY UNTREATED PROSTATIC CANCER PATIENTS

1986 • 69 citations

Differences in inducibility of cutaneous and hepatic drug metabolizing enzymes and cytochrome P-450 by polychlorinated biphenyls and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).

1974 • 68 citations

Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo

1987 • 66 citations

Mouse Epidermal Aryl Hydrocarbon Hydroxylase

1976 • 60 citations

Quantitative Real-Time Reverse Transcription–Polymerase Chain Reaction Analysis of Drug Metabolizing and Cytoprotective Genes in Psoriasis and Regulation by Ultraviolet Radiation

2003 • 57 citations

Inhibition of the metabolism of endogenous retinoic acid as treatment for severe psoriasis: an open study with oral liarozole

1995 • 51 citations

The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin

1998 • 50 citations

Cutaneous Cytochrome P-450

1989 • 50 citations

Inhibition of retinoic acid metabolism by imidazole antimycotics in F9 embryonal carcinoma cells

1987 • 47 citations

The Retinoid X Receptor Agonist 9-cis-Retinoic Acid and the 24-Hydroxylase Inhibitor Ketoconazole Increase Activity of 1,25-Dihydroxyvitamin D3 in Human Skin In Vivo

1997 • 46 citations

Aryl Hydrocarbon (Benzo[A]Pyrene) Hydroxylase: A Mixed-Function Oxygenase in Mouse Skin

1975 • 43 citations

Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models

2002 • 42 citations

Role of 5-Lipoxygenase Products in the Local Accumulation of Neutrophils in Dermal Inflammation in the Rabbit

1999 • 41 citations

Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin

1989 • 40 citations

Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation.

2001 • 38 citations

Vitamin D and the Skin

2003 • 37 citations

Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes

2002 • 36 citations

Age-related changes in benzo(a)pyrene metabolism and epoxide-metabolizing enzyme activities in rat skin.

1983 • 36 citations

Clotrimazole, an inhibitor of epidermal benzo(a)pyrene metabolism and DNA binding and carcinogenicity of the hydrocarbon.

1984 • 35 citations

Microscope immersion oils: effects of skin application on cutaneous and hepatic drug-metabolizing enzymes

1975 • 33 citations

Effect of topical application of defined constituents of coal tar on skin and liver aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase activities

1982 • 31 citations

The Cloning and Characterization of a Novel Cytochrome P450 Family, CYP26, with Specificity Toward Retinoic Acid

2009 • 30 citations

Induction of CYP1A1 mRNA in rat epidermis and cultured human epidermal keratinocytes by benz(a)anthracene and beta-naphthoflavone.

1992 • 25 citations

Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism

2003 • 24 citations

Cytochrome P-450-Dependent Omega-Oxidation of Leukotriene B4 in Rodent and Human Epidermis

1989 • 24 citations

Induction of Neonatal Rat Skin and Liver Aryl Hydrocarbon Hydroxylase by Coal Tar and Its Constituents

1982 • 24 citations

Expression, structure‐function, and molecular modeling of vitamin D P450s

2003 • 23 citations

Induction by topical corticosteroids of skin enzymes metabolizing carcinogenic hydrocarbons

2006 • 23 citations

Induction of benzo[α]pyrene hydroxylase activity in rat skin

1970 • 23 citations

Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation.

1992 • 23 citations

Purification and Molecular Characterization of β-Naphthoflavone–Inducible Cytochrome P-450 from Rat Epidermis

1992 • 22 citations

Epidermal cytochrome P-450: immunochemical characterization of isoform induced by topical application of 3-methylcholanthrene to neonatal rat.

1989 • 21 citations

Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin

1995 • 19 citations

Flow cytometry reveals subpopulations of murine epidermal cells that are refractory to induction of cytochrome P-4501A1 by beta-naphthoflavone.

1995 • 19 citations

Induction of drug metabolising enzymes in the skin by topical steroids

1984 • 17 citations

Evidence that coal tar is a mixed inducer of microsomal drug-metabolizing enzymes

1982 • 17 citations

New and prospective developments in antifungal drugs.

1986 • 16 citations

Evidence for Multiple Inducible Cytochrome P450 Isozymes in Sencar Mouse Skin by Pyridine

1994 • 15 citations

Clotrimazole, an Inhibitor of Benzo[a]pyrene Metabolism and Its Subsequent Glucuronidation, Sulfation, and Macromolecular Binding in BALB/c Mouse Cultured Keratinocytes

1986 • 14 citations

Biophysics and Molecular Biology

1962 • 13 citations

Differences in inducibility of cytochrome p-4501a1, monooxygenases and glutathione s-transferase in cutaneous and extracutaneous tissues after topical and parenteral administration of β-naphthoflavone to rats

1993 • 12 citations

Induction of UDP-glucuronyltransferase and arylhydrocarbon hydroxylase activity in mouse skin and in normal and transformed skin cells in culture

1986 • 12 citations

Topical steroid treatment reduces arachidonic acid and leukotriene B4 in lesional skin of psoriasis.

1986 • 12 citations

Effect of topical application of clotrimazole to rats on epidermal and hepatic monooxygenase activities and cytochrome P-450

1989 • 10 citations

Ketoconazole in the Treatment of Acne in Women

1986 • 5 citations

Deleted Work

1955 • 0 citations