Elucidation of the separate roles of myosins IIA and IIB during neurite outgrowth, adhesion and retraction

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Single myosin molecule mechanics: piconewton forces and nanometre steps

1994 • 1,894 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

Bead movement by single kinesin molecules studied with optical tweezers

1990 • 1,018 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

RHO GTPASES in neuronal morphogenesis

2000 • 982 citations

Movement of microtubules by single kinesin molecules

1989 • 878 citations

Cytoskeletal dynamics and nerve growth

1988 • 855 citations

Rac Downregulates Rho Activity

1999 • 840 citations

Fluorescent actin filaments move on myosin fixed to a glass surface.

1986 • 839 citations

Myosins: a diverse superfamily

2000 • 817 citations

A Millennial Myosin Census

2001 • 745 citations

Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation

1997 • 700 citations

Mechanism of Actin-Based Motility

2001 • 694 citations

Widespread occurrence of antisense transcription in the human genome

2003 • 655 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Novel myosin heavy chain encoded by murine dilute coat colour locus

1991 • 534 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction

1999 • 408 citations

Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones

1996 • 403 citations

Growth cone advance is inversely proportional to retrograde F-actin flow

1995 • 371 citations

Myosin-X is an unconventional myosin that undergoes intrafilopodial motility

2002 • 362 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Focal Adhesion Motility Revealed in Stationary Fibroblasts

1999 • 345 citations

Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance

2000 • 339 citations

Rac GTPases control axon growth, guidance and branching

2002 • 335 citations

Neuronal Cytomechanics: The Actin-Based Motility of Growth Cones

1988 • 331 citations

Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity.

1992 • 305 citations

Nonmuscle myosin II-B is required for normal development of the mouse heart

1997 • 304 citations

Signalling and crosstalk of Rho GTPases in mediating axon guidance

2002 • 299 citations

Sliding movement of single actin filaments on one-headed myosin filaments

1987 • 297 citations

Rho: theme and variations

1996 • 290 citations

Direct evidence that growth cones pull

1989 • 287 citations

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape

1992 • 274 citations

Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.

1991 • 270 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Regulation of Actin Polymerization by Arp2/3 Complex and WASp/Scar Proteins

1999 • 259 citations

Culture of neural cells on silicon wafers with nano-scale surface topograph

2002 • 258 citations

Mechanical tension produced by nerve cells in tissue culture

1979 • 254 citations

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

1992 • 245 citations

Myosin II activation promotes neurite retraction during the action of Rho and Rho‐kinase

1998 • 243 citations

Kinetic Mechanism of Non-muscle Myosin IIB

2003 • 241 citations

The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments

2001 • 223 citations

Myosin IIB Is Required for Growth Cone Motility

2001 • 219 citations

The organization of myosin and actin in rapid frozen nerve growth cones.

1989 • 215 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides.

1991 • 211 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate–Cytoskeletal Coupling

1998 • 209 citations

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

1998 • 199 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca²⁺ Signaling and Rho

1996 • 198 citations

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.

1992 • 188 citations

Attachment of astroglial cells to microfabricated pillar arrays of different geometries

2000 • 184 citations

Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones

1996 • 183 citations

Conditional Expression of a Truncated Fragment of Nonmuscle Myosin II-A Alters Cell Shape but Not Cytokinesis in HeLa Cells

2000 • 181 citations

Localization of myosin II A and B isoforms in cultured neurons

1995 • 180 citations

Cytoplasmic dynamics of myosin IIA and IIB: spatial ‘sorting’ of isoforms in locomoting cells

1998 • 177 citations

Tissue distribution and subcellular localization of mammalian myosin I.

1992 • 175 citations

RNAi functions in cultured mammalian neurons

2002 • 173 citations

Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.

1996 • 167 citations

Axonal outgrowth of hippocampal neurons on micro-scale networks of polylysine-conjugated laminin

2001 • 167 citations

p160 RhoA-binding Kinase ROKα Induces Neurite Retraction

1998 • 166 citations

Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.

1993 • 160 citations

Actin dynamics in growth cones

1991 • 145 citations

The Nerve Growth Cone

1991 • 142 citations

Astrocyte process growth induction by actin breakdown

1992 • 141 citations

Actin Motion on Microlithographically Functionalized Myosin Surfaces and Tracks

1999 • 136 citations

Two distinct nonmuscle myosin‐heavy‐chain mRNAs are differentially expressed in various chicken tissues

1989 • 132 citations

Actin turnover is required to prevent axon retraction driven by endogenous actomyosin contractility

2002 • 129 citations

Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone

2002 • 129 citations

Phosphatidylinositol 3-Kinase, Cdc42, and Rac1 Act Downstream of Ras in Integrin-Dependent Neurite Outgrowth in N1E-115 Neuroblastoma Cells

2000 • 125 citations

Studies on the organization and localization of actin and myosin in neurons.

1979 • 121 citations

Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II‐B heavy chain

2001 • 117 citations

Control of actin moving trajectory by patterned poly(methylmethacrylate) tracks

1997 • 114 citations

Subcellular localization of myosin V in nerve growth cones and outgrowth from dilute-lethal neurons

1997 • 107 citations

Myosin IIB Is Unconventionally Conventional

2003 • 106 citations

The clutch hypothesis revisited: Ascribing the roles of actin-associated proteins in filopodial protrusion in the nerve growth cone

2000 • 102 citations

Two Nonmuscle Myosin II Heavy Chain Isoforms Expressed in Rabbit Brains: Filament Forming Properties, the Effects of Phosphorylation by Protein Kinase C and Casein Kinase II, and Location of the Phosphorylation Sites

1998 • 102 citations

A conventional myosin motor drives neurite outgrowth

1998 • 100 citations

Organization of point contacts in neuronal growth cones

1999 • 100 citations

Myosin II distribution in neurons is consistent with a role in growth cone motility but not synaptic vesicle mobilization

1992 • 94 citations

Sensory neurite growth cone guidance by substrate adsorbed nerve growth factor

1985 • 91 citations

Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowth

2000 • 91 citations

Modulation of cellular morphology and locomotory activity by antibodies against myosin.

1988 • 88 citations

The Myotonic Dystrophy Kinase-related Cdc42-binding Kinase Is Involved in the Regulation of Neurite Outgrowth in PC12 Cells

1999 • 88 citations

Chick sensory neuronal growth cones distinguish fibronectin from laminin by making substratum contacts that resemble focal contacts

1996 • 85 citations

Requirement for Rho-mediated Myosin Light Chain Phosphorylation in Thrombin-stimulated Cell Rounding and Its Dissociation from Mitogenesis

1998 • 84 citations

Network contraction model for cell translocation and retrograde flow.

1999 • 80 citations

Rac is required for growth cone function but not neurite assembly

1997 • 75 citations

Neuronal Cell Expression of Inserted Isoforms of Vertebrate Nonmuscle Myosin Heavy Chain II-B

1995 • 74 citations

Myr 7 is a novel myosin IX-RhoGAP expressed in rat brain

1998 • 72 citations

The structure and function of unconventional myosins: a review

1994 • 67 citations

Cell Crawling: First the Motor, Now the Transmission

1998 • 59 citations

Localization of unconventional myosins V and VI in neuronal growth cones

2000 • 57 citations

Association of a cellular myosin II with anionic phospholipids and the neuronal plasma membrane.

1994 • 55 citations

Myosin functions inXenopus retinal ganglion cell growth cone motilityin vivo

1997 • 51 citations

Localization of myosin IIB at the leading edge of growth cones from rat dorsal root ganglionic cells

1992 • 50 citations

Myosin light chain phosphorylation and growth cone motility

2002 • 45 citations

Phosphorylation-dependent Regulation Is Absent in a Nonmuscle Heavy Meromyosin Construct with One Complete Head and One Head Lacking the Motor Domain

2001 • 41 citations

Movement of myosin‐coated structures on actin cables

1983 • 39 citations

Growth cones contain myosin II bipolar filament arrays

2002 • 37 citations

Cell behaviour : control and mechanism of motility

1999 • 31 citations

Integrin-Mediated Tyrosine Phosphorylation and Redistribution of Paxillin during Neuronal Adhesion

1997 • 30 citations

Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages

1993 • 27 citations

Studies of the Chemo-Mechanical Conversion in Artificially Produced Streamings

1978 • 19 citations

Concentration-dependent stimulation and inhibition of growth cone behavior and neurite elongation by protein kinase inhibitors KT5926 and K-252a

1997 • 16 citations

Evidence for a New Member of the Myosin I Family from Mammalian Brain

1992 • 12 citations

Cell behaviour : control and mechanism of motility : 4th Abercrombie Conference on Cell Behaviour held at St Catherine's College, Oxford, 28 September-1 October 1997

1999 • 1 citations