From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

2016 • 7,054 citations

Complement: a key system for immune surveillance and homeostasis

2010 • 3,243 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells

1997 • 1,755 citations

The epidemiology of UV induced skin cancer

2001 • 1,731 citations

Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip

1992 • 1,439 citations

The human keratins: biology and pathology

2008 • 1,324 citations

Tetraspanin functions and associated microdomains

2005 • 1,254 citations

Cutaneous Squamous-Cell Carcinoma

2001 • 1,247 citations

The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

2001 • 1,186 citations

Complement regulators and inhibitory proteins

2009 • 1,176 citations

Incidence Estimate of Nonmelanoma Skin Cancer in the United States, 2006

2010 • 1,139 citations

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

2010 • 1,137 citations

UV-light-induced signal cascades and skin aging

2002 • 881 citations

Non-melanoma skin cancer

2010 • 803 citations

Multicenter Phase II Study of Erlotinib, an Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

2003 • 803 citations

An overview of the serpin superfamily.

2006 • 631 citations

Phase II Trial of ZD1839 in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

2003 • 616 citations

The risk of progression to invasive disease

2000 • 456 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

2011 • 435 citations

History of Circumcision, Medical Conditions, and Sexual Activity and Risk of Penile Cancer

1993 • 427 citations

Squamous cell carcinoma of the skin (excluding lip and oral mucosa)

1992 • 417 citations

Molecular Cloning, Occurrence, and Expression of a Novel Partially Secreted Protein “Psoriasin” That Is Highly Up-Regulated in Psoriatic Skin

1991 • 410 citations

High Prevalence of Papillomavirus-Associated Penile Intraepithelial Neoplasia in Sexual Partners of Women with Cervical Intraepithelial Neoplasia

1987 • 386 citations

Epidermolysis bullosa and the risk of life-threatening cancers: The National EB Registry experience, 1986-2006

2008 • 380 citations

A survey of transformation markers in differentiating epidermal cell lines in culture.

1980 • 320 citations

Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma

2012 • 289 citations

Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H

2007 • 280 citations

The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells

2008 • 275 citations

Predictions of skin cancer incidence in the Netherlands up to 2015

2005 • 253 citations

Melanocortin-1 Receptor Gene Variants Determine the Risk of Nonmelanoma Skin Cancer Independently of Fair Skin and Red Hair

2001 • 248 citations

Photoprotective properties of skin melanin

2002 • 229 citations

Field effect in cancer-an update.

2009 • 212 citations

A Prospective Study of Serum C-Reactive Protein and Colorectal Cancer Risk in Men

2006 • 207 citations

Heat Shock Protein 70 Is Required for the Survival of Cancer Cells

2000 • 205 citations

p53 and the pathogenesis of skin cancer

2006 • 199 citations

Metastatic Cutaneous Squamous Cell Carcinoma: An Update

2007 • 194 citations

Proteinases in cutaneous wound healing

2008 • 192 citations

Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition.

2003 • 174 citations

Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT–PCR in patients with metastatic breast cancer

2009 • 171 citations

HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells

2010 • 155 citations

FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function

1999 • 146 citations

Bladder Squamous Cell Carcinomas Express Psoriasin and Externalize it to the Urine

1996 • 146 citations

Temporal Events in Skin Injury and the Early Adaptive Responses in Ultraviolet-Irradiated Mouse Skin

2000 • 145 citations

Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis

2011 • 143 citations

Disruption of EphA2 Receptor Tyrosine Kinase Leads to Increased Susceptibility to Carcinogenesis in Mouse Skin

2006 • 135 citations

CD133 Expression and the Prognosis of Colorectal Cancer: A Systematic Review and Meta-Analysis

2013 • 133 citations

Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival.

2002 • 123 citations

The adenomatous polyposis coli (APC) tumour suppressor – genetics, function and disease

2000 • 123 citations

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways

2011 • 120 citations

Roles of the transcription factor p53 in keratinocyte carcinomas

2006 • 114 citations

The mechanistic basis of arsenicosis: Pathogenesis of skin cancer

2014 • 111 citations

Expression of Ephb2 and Ephb4 in breast carcinoma

2004 • 110 citations

Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): Results of a phase II study

2004 • 109 citations

Proteomic identification of malignant transformation‐related proteins in esophageal squamous cell carcinoma

2008 • 106 citations

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

2016 • 104 citations

APC EXPRESSION IN NORMAL HUMAN TISSUES

1997 • 103 citations

Association of Circulating Tumor Cells with Serum Tumor-Related Methylated DNA in Peripheral Blood of Melanoma Patients

2006 • 100 citations

Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation

2013 • 97 citations

In Vivo SILAC-Based Proteomics Reveals Phosphoproteome Changes during Mouse Skin Carcinogenesis

2013 • 93 citations

Epidermal growth factor receptor: a novel biomarker for aggressive head and neck cutaneous squamous cell carcinoma

2007 • 92 citations

Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases

2011 • 90 citations

CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis

2008 • 90 citations

Proteomics in Cancer Biomarkers Discovery: Challenges and Applications

2015 • 87 citations

Morbus Bowen. A description of the disease in 617 patients.

1988 • 85 citations

Complement Factor H: A Biomarker for Progression of Cutaneous Squamous Cell Carcinoma

2013 • 85 citations

Implications of cytokeratin 8/18 filament formation in stratified epithelial cells: Induction of transformed phenotype

2004 • 85 citations

Clinicopathologic Variants of Cutaneous Squamous Cell Carcinoma

2001 • 83 citations

Serpin Peptidase Inhibitor Clade A Member 1 (SerpinA1) Is a Novel Biomarker for Progression of Cutaneous Squamous Cell Carcinoma

2011 • 80 citations

Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours

2006 • 78 citations

Transfection of Keratin 18 Gene in Human Breast Cancer Cells Causes Induction of Adhesion Proteins and Dramatic Regression of Malignancy In vitro and In vivo

2005 • 77 citations

Matrix metalloproteinase-7 activates heparin-binding epidermal growth factor-like growth factor in cutaneous squamous cell carcinoma

2010 • 76 citations

Parotid metastasis – An independent prognostic factor for head and neck cutaneous squamous cell carcinoma

2006 • 75 citations

Nuclear S100A7 Is Associated with Poor Prognosis in Head and Neck Cancer

2010 • 74 citations

Prognostic significance of tumour marker index based on preoperative CEA and CYFRA 21-1 in non-small cell lung cancer.

2010 • 73 citations

Cyfra 21-1: A New Potential Tumor Marker for Squamous Cell Carcinoma of Head and Neck

1995 • 72 citations

Prognostic Value of Cancer Stem Cell Marker CD133 Expression in Gastric Cancer: A Systematic Review

2013 • 72 citations

Epidemiological aspects of penile cancer in Rio de Janeiro: evaluation of 230 cases

2011 • 71 citations

Tetraspanin CD151 plays a key role in skin squamous cell carcinoma

2012 • 70 citations

Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification

2006 • 69 citations

Basal cell carcinoma: cell of origin, cancer stem cell hypothesis and stem cell markers

2010 • 68 citations

IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients

2011 • 68 citations

Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas

2008 • 67 citations

Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

2015 • 67 citations

Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck

2009 • 66 citations

Telomerase activity in melanoma and non-melanoma skin cancer

1998 • 66 citations

Psoriasin (S100A7) up-regulation in oral squamous cell carcinoma and its relation to clinicopathologic features

2009 • 65 citations

Molecular genetics of cancer.

1992 • 64 citations

Mitochondrial DNA Mutation in Normal Margins and Tumors of Recurrent Head and Neck Squamous Cell Carcinoma Patients

2010 • 63 citations

Biomarkers p16, Human Papillomavirus and p53 Predict Recurrence and Survival in Early Stage Squamous Cell Carcinoma of the Vulva

2016 • 62 citations

Glomerular C3c localization indicates ongoing immune deposit formation and complement activation in experimental glomerulonephritis.

1993 • 61 citations

HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes

2007 • 55 citations

Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma

2005 • 55 citations

Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features

2008 • 54 citations

Epidemiological aspects of cancer of the penis in Finland

1992 • 54 citations

Immunomics in Skin Cancer - Improvement in Diagnosis, Prognosis and Therapy Monitoring

2013 • 52 citations

Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.

1997 • 52 citations

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma

2015 • 51 citations

Epidermal growth factor receptor directed therapy in head and neck cancer

2005 • 51 citations

Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2

2009 • 50 citations

Immune Parameters in The Prognosis and Therapy Monitoring of Cutaneous Melanoma Patients: Experience, Role, and Limitations

2013 • 50 citations

BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization

2009 • 48 citations

Oral keratinocyte stem/progenitor cells: specific markers, molecular signaling pathways and potential uses

2015 • 48 citations

Dermatofibrosarcoma protuberans: a tumour of nestin-positive cutaneous mesenchymal stem cells?

2009 • 48 citations

Immune-related biomarkers for diagnosis/prognosis and therapy monitoring of cutaneous melanoma

2010 • 48 citations

Reflectance confocal microscopy and dermoscopy for in vivo, non-invasive skin imaging of superficial basal cell carcinoma

2016 • 48 citations

Proteomics focusing on immune markers in psoriatic arthritis

2014 • 47 citations

Squamous cell carcinoma of the skin: Emerging need for novel biomarkers

2013 • 43 citations

Tumor volume and tumor marker index based on CYFRA 21-1 and CEA are strong prognostic factors in operated early stage NSCLC

2008 • 41 citations

Novel Serum Biomarkers to Differentiate Cholangiocarcinoma from Benign Biliary Tract Diseases Using a Proteomic Approach

2015 • 41 citations

Immunolocalization of Vimentin, Keratin 17, Ki-67, Involucrin, β-Catenin and E-Cadherin in Cutaneous Squamous Cell Carcinoma

2013 • 39 citations

The Immune System—A Hidden Treasure for Biomarker Discovery in Cutaneous Melanoma

2012 • 38 citations

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients

2013 • 38 citations

Strong correlation between N-cadherin and CD133 in breast cancer: role of both markers in metastatic events

2014 • 38 citations

Detection of serum Cyfra 21-1 in patients with primary oral squamous cell carcinoma

2006 • 37 citations

Analytical and clinical evaluation of CYFRA 21-1 by electrochemiluminescent immunoassay in head and neck squamous cell carcinoma

2003 • 36 citations

Protein microarray for complex apoptosis monitoring of dysplastic oral keratinocytes in experimental photodynamic therapy

2014 • 35 citations

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma

2012 • 35 citations

alpha1-antitrypsin and its C-terminal fragment attenuate effects of degranulated neutrophil-conditioned medium on lung cancer HCC cells, in vitro.

2004 • 34 citations

Circulating miRNA signature for early diagnosis of lung cancer

2011 • 34 citations

Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma

2015 • 33 citations

Advances in Pancreatic Cancer Detection

2010 • 32 citations

Comparison of Cyfra 21-1 and SCC Assays in Head and Neck Tumours

2001 • 31 citations

Expression of the stem cell marker nestin in peripheral blood of patients with melanoma

2010 • 31 citations

Inflammation markers in cutaneous melanoma - edgy biomarkers for prognosis

2015 • 30 citations

Key signaling molecules in pituitary tumors

2009 • 28 citations

Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A

2009 • 28 citations

Follow-Up with Serum Cyfra 21-1 in Patients with Squamous Cell Carcinomas of the Head and Neck

2002 • 27 citations

High levels of type VII collagen expression in recessive dystrophic epidermolysis bullosa cutaneous squamous cell carcinoma keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

2013 • 27 citations

Phase II study of gefitinib in patients with metastatic/recurrent squamous cell carcinoma of the skin

2006 • 27 citations

Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma

2010 • 25 citations

Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma

2014 • 25 citations

The C‐terminal 26‐residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47

2004 • 24 citations

Ultraviolet Radiation Effects on the Proteome of Skin Cells

2013 • 23 citations

Comparison of the effects of purified human α1-antichymotrypsin and α1-proteinase inhibitor on NK cytotoxicity: only α1-proteinase inhibitor inhibits natural killing

1990 • 21 citations

Cut-off value determination of CYFRA 21-1 for squamous cell carcinomas of the head and neck (SCCHN).

1997 • 20 citations

The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy

2016 • 19 citations

Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice

2012 • 19 citations

Proteomics-Based Identification of Differentially Abundant Proteins from Human Keratinocytes Exposed to Arsenic Trioxide

2014 • 19 citations

The Characteristics and Function of S100A7 Induction in Squamous Cell Carcinoma: Heterogeneity, Promotion of Cell Proliferation and Suppression of Differentiation

2015 • 18 citations

Cyfra 21-1 as a serum tumor marker for follow-up of patients with laryngeal and hypopharyngeal squamous cell carcinoma.

2009 • 17 citations

UVB-induced experimental carcinogenesis: dysregulation of apoptosis and p53 signalling pathway

2000 • 16 citations

CD133+ cell content correlates with tumour growth in melanomas from skin with chronic sun-induced damage

2013 • 11 citations

Patented Biomarker Panels in Early Detection of Cancer

2011 • 11 citations

Reduction in ERRα is associated with lichen sclerosus and vulvar squamous cell carcinoma

2015 • 10 citations

Genetic association between p53 codon 72 polymorphism and risk of cutaneous squamous cell carcinoma

2013 • 9 citations

Proteome profiling of keratinocytes transforming to malignancy

2014 • 9 citations

Effects of Ultraviolet Radiation on Skin Cell Proteome

2013 • 9 citations

CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors

2013 • 9 citations

Clinical significance of galectin-7 in vulvar squamous cell carcinoma

2015 • 8 citations

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation.

2012 • 5 citations

Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus

2015 • 5 citations