The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Identification of human brain tumour initiating cells

2004 • 7,166 citations

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

2006 • 6,005 citations

Identification of a cancer stem cell in human brain tumors.

2003 • 4,784 citations

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

2006 • 4,012 citations

Identification and expansion of human colon-cancer-initiating cells

2006 • 3,914 citations

Prospective Identification of Tumorigenic Prostate Cancer Stem Cells

2005 • 2,784 citations

Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer

2007 • 2,743 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

2000 • 2,286 citations

Direct isolation of human central nervous system stem cells

2000 • 1,822 citations

AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells

1997 • 1,755 citations

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

2006 • 1,747 citations

Identification and expansion of the tumorigenic lung cancer stem cell population

2007 • 1,658 citations

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells

2006 • 1,148 citations

Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells

2007 • 1,123 citations

CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles

2007 • 1,117 citations

HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity

2006 • 1,016 citations

The Biology of Cancer Stem Cells

2007 • 1,012 citations

A Novel Five-Transmembrane Hematopoietic Stem Cell Antigen: Isolation, Characterization, and Molecular Cloning

1997 • 935 citations

Radial glia cells are candidate stem cells of ependymoma

2005 • 791 citations

CD133, a novel marker for human prostatic epithelial stem cells

2004 • 773 citations

CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway

2007 • 759 citations

Cancer stem cells in nervous system tumors

2004 • 727 citations

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

2000 • 720 citations

Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells

1997 • 603 citations

Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells

2006 • 601 citations

CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity

2007 • 554 citations

Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential

2007 • 554 citations

CD133: molecule of the moment

2007 • 514 citations

The Human AC133 Hematopoietic Stem Cell Antigen Is also Expressed in Epithelial Cells and Targeted to Plasma Membrane Protrusions

2000 • 434 citations

Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria

2007 • 404 citations

Prominin: A Story of Cholesterol, Plasma Membrane Protrusions and Human Pathology

2001 • 309 citations

Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer

2004 • 283 citations

A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration

2000 • 271 citations

Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133− cells, and the CD133+ sector is enlarged by hypoxia

2006 • 256 citations

Expression of CD133-1 and CD133-2 in ovarian cancer

2007 • 219 citations

CD133 Is Not Present on Neurogenic Astrocytes in the Adult Subventricular Zone, but on Embryonic Neural Stem Cells, Ependymal Cells, and Glioblastoma Cells

2007 • 197 citations

Detection of tumor stem cell markers in pancreatic carcinoma cell lines.

2007 • 181 citations

AC133-2, a Novel Isoform of Human AC133 Stem Cell Antigen

2002 • 162 citations

Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133

2003 • 160 citations

Influence of oxygen tension on CD133 phenotype in human glioma cell cultures

2007 • 157 citations

Biological and Genetic Characteristics of Tumor-Initiating Cells in Colon Cancer

2007 • 146 citations

Effects of Hypoxia on the Proliferation and Differentiation of NSCs

2005 • 141 citations

Human skin‐derived stem cells migrate throughout forebrain and differentiate into astrocytes after injection into adult mouse brain

2004 • 138 citations

New Insights into the Cell Biology of Hematopoietic Progenitors by Studying Prominin-1 (CD133)

2007 • 134 citations

Identification of novel Prominin-1/CD133 splice variants with alternative C-termini and their expression in epididymis and testis

2004 • 127 citations

CD133, One of the Markers of Cancer Stem Cells in Hep‐2 Cell Line

2007 • 125 citations

Brain Tumor Stem Cells

2006 • 111 citations

Biology of Normal and Acute Myeloid Leukemia Stem Cells

2005 • 107 citations

Cancer Stem Cells

2006 • 92 citations

Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells

2007 • 82 citations

The Efficacy of Epidermal Growth Factor Receptor–Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization

2007 • 78 citations

Fetal Human Hematopoietic Stem Cells Can Differentiate Sequentially into Neural Stem Cells and Then Astrocytes In Vitro

2003 • 72 citations

Lack of IRF-1 expression in acute promyelocytic leukemia and in a subset of acute myeloid leukemias with del(5)(q31)

1999 • 55 citations

Monoclonal Antibody CD133–2 (AC141) Against Hematopoietic Stem Cell Antigen CD133 Shows Crossreactivity with Cytokeratin 18

2002 • 41 citations