The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

1999 • 1,494 citations

Structure of a serpin–protease complex shows inhibition by deformation

2000 • 1,054 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

1994 • 879 citations

Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

2000 • 556 citations

Maspin is an angiogenesis inhibitor

2000 • 463 citations

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

1999 • 429 citations

What do dysfunctional serpins tell us about molecular mobility and disease?

1995 • 420 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

Familial dementia caused by polymerization of mutant neuroserpin

1999 • 344 citations

Cross-Class Inhibition of the Cysteine Proteinases Cathepsins K, L, and S by the Serpin Squamous Cell Carcinoma Antigen 1: A Kinetic Analysis

1998 • 279 citations

Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis

2000 • 262 citations

Inhibitory conformation of the reactive loop of α1-antitrypsin

1996 • 243 citations

Plasminogen Activator Inhibitor Type 2 Inhibits Tumor Necrosis Factor α-induced Apoptosis

1995 • 225 citations

The ovalbumin family of serpin proteins

1993 • 221 citations

Neuroserpin, a Brain-associated Inhibitor of Tissue Plasminogen Activator Is Localized Primarily in Neurons

1997 • 214 citations

Inhibition of Angiogenesis in Vivo by Plasminogen Activator Inhibitor-1

2001 • 177 citations

Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

2000 • 171 citations

Serpins: Structure, Function and Biology

1996 • 168 citations

Serine proteinase inhibitors from nematodes and the arms race between host and pathogen

2001 • 149 citations

Inhibitory Serpins from Wheat Grain with Reactive Centers Resembling Glutamine-rich Repeats of Prolamin Storage Proteins

2000 • 119 citations

MENT, a Heterochromatin Protein That Mediates Higher Order Chromatin Folding, Is a New Serpin Family Member

1999 • 114 citations

Effects of Serpin Binding on the Target Proteinase: Global Stabilization, Localized Increased Structural Flexibility, and Conserved Hydrogen Bonding at the Active Site

1997 • 95 citations

Inhibition of Soluble Recombinant Furin by Human Proteinase Inhibitor 8

1998 • 91 citations

Characterization of Cucurbita maxima Phloem Serpin-1 (CmPS-1)

2000 • 86 citations

Plasminogen activator inhibitor type 2 in breast cancer

1997 • 72 citations

The use of α2-Antiplasmin as a Model for the Demonstration of Complex Reversibility in Serpins

1989 • 65 citations

Regulation of pro‐apoptotic leucocyte granule serine proteinases by intracellular serpins

1999 • 64 citations

A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.

1994 • 60 citations

Crystal structure of the apoptotic suppressor CrmA in its cleaved form

2000 • 58 citations

Intracellular Polymerization of the Serpin Plasminogen Activator Inhibitor Type 2

1996 • 57 citations

Biology and Facultative Secretion of Plasminogen Activator Inhibitor-2

1993 • 50 citations

Human Ovalbumin Serpin Evolution: Phylogenic Analysis, Gene Organization, and Identification of New PI8-Related Genes Suggest That Two Interchromosomal and Several Intrachromosomal Duplications Generated the Gene Clusters at 18q21–q23 and 6p25

1999 • 50 citations

Recombinant Human Monocyte/Neutrophil Elastase Inhibitor Protects Rat Lungs against Injury from Cystic Fibrosis Airway Secretions

1999 • 44 citations

Keeping the Serpin Machine Running Smoothly: Figure 1.

2000 • 40 citations

Identification of a Nuclear Targeting Domain in the Insertion between Helices C and D in Protease Inhibitor-10

1999 • 37 citations

Two Distinct Urokinase-Serpin Interactions Regulate the Initiation of Cell Surface-associated Plasminogen Activation

1999 • 33 citations

Human Cytoplasmic Antiproteinase Neutralizes Rapidly and Efficiently Chymotrypsin and Trypsin-like Proteases Utilizing Distinct Reactive Site Residues

1996 • 25 citations

Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of alzheimer's disease

1999 • 24 citations

Human Proteinase Inhibitor 9 (PI9) Is a Potent Inhibitor of Subtilisin A

1997 • 22 citations

Purification, cDNA Cloning, and Characterization of a New Serpin with Megakaryocyte Maturation Activity

1997 • 16 citations