Familial Pancreatic Cancer

Cancer Statistics, 2008

2008 • 10,165 citations

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

2005 • 4,715 citations

Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

2000 • 4,020 citations

Cancer incidence, mortality and prevalence worldwide

2004 • 3,893 citations

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

2009 • 3,433 citations

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

2006 • 3,040 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

2003 • 2,056 citations

Pancreatitis and the Risk of Pancreatic Cancer

1993 • 1,714 citations

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

1996 • 1,600 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Cancer Risks in BRCA2 Mutation Carriers

1999 • 1,477 citations

Very high risk of cancer in familial Peutz–Jeghers syndrome

2000 • 1,386 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Cancer Incidence in BRCA1 Mutation Carriers

2002 • 1,064 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

2000 • 1,019 citations

Hereditary Pancreatitis and the Risk of Pancreatic Cancer

1997 • 968 citations

Incidence of Cancer in 161 Families Affected by Ataxia–Telangiectasia

1991 • 944 citations

Relation between Mutations of the Cystic Fibrosis Gene and Idiopathic Pancreatitis

1998 • 923 citations

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

2008 • 874 citations

Increased Risk of Cancer in the Peutz–Jeghers Syndrome

1987 • 865 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

2009 • 798 citations

Diabetes Mellitus as a Predictor of Cancer Mortality in a Large Cohort of US Adults

2004 • 776 citations

Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2

1996 • 762 citations

Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program

2002 • 715 citations

Tumor suppression by Ink4a–Arf: progress and puzzles

2003 • 700 citations

Diabetes Mellitus as a Risk Factor for Pancreatic Cancer

1995 • 694 citations

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

2004 • 657 citations

Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer

2001 • 653 citations

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.

1996 • 637 citations

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.

1997 • 632 citations

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16^INK4Mutations

1995 • 620 citations

Clinical and genetic characteristics of hereditary pancreatitis in Europe

2004 • 603 citations

Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases

1997 • 580 citations

A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes

1996 • 525 citations

The genetics of hereditary colon cancer

2007 • 515 citations

Screening for Early Pancreatic Neoplasia in High-Risk Individuals: A Prospective Controlled Study

2006 • 508 citations

Risk of Pancreatic Cancer in Families With Lynch Syndrome

2009 • 498 citations

Hereditary cancer: Two hits revisited

1996 • 497 citations

Histopathological Identification of Colon Cancer with Microsatellite Instability

2001 • 491 citations

BRCA2 Germline Mutations in Familial Pancreatic Carcinoma

2003 • 482 citations

Probability of Pancreatic Cancer Following Diabetes: A Population-Based Study

2005 • 476 citations

Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach

2004 • 451 citations

Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.

2002 • 434 citations

Probability of Pancreatic Cancer Following Diabetes: A Population-Based Study

2005 • 430 citations

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

1997 • 428 citations

Increased Risk for Cancer in Patients with the Peutz-Jeghers Syndrome

1998 • 426 citations

GLOBOCAN 2000. Cancer incidence, mortality and prevalence worldwide, Version 1.0

2001 • 422 citations

Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers

1999 • 417 citations

Pedigree of a Family with Hereditary Chronic Relapsing Pancreatitis

1952 • 416 citations

High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL

2006 • 402 citations

Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer

1999 • 398 citations

Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents

2006 • 398 citations

Early Diagnosis and Treatment of Pancreatic Dysplasia in Patients with a Family History of Pancreatic Cancer

1999 • 392 citations

Prediction of Germline Mutations and Cancer Risk in the Lynch Syndrome

2006 • 380 citations

BRCA2 germline mutations in male breast cancer cases and breast cancer families

1996 • 363 citations

Familial atypical multiple mole-melanoma syndrome.

1978 • 361 citations

Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis.

1993 • 357 citations

Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset

2005 • 357 citations

High Frequency of Multiple Melanomas and Breast and Pancreas Carcinomas in CDKN2A Mutation-Positive Melanoma Families

2000 • 344 citations

A meta-analysis of obesity and the risk of pancreatic cancer

2003 • 338 citations

Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression.

1998 • 333 citations

A gene for hereditary pancreatitis maps to chromosome 7q35

1996 • 330 citations

Cancer and the Peutz-Jeghers syndrome.

1989 • 322 citations

Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion ofp16 (p16-Leiden)

2000 • 321 citations

Cigarette Smoking as a Risk Factor for Pancreatic Cancer in Patients With Hereditary Pancreatitis

2001 • 319 citations

Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.

2006 • 315 citations

Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 p16Leiden

2000 • 311 citations

Risk Factors for Pancreatic Cancer: Case-Control Study

2007 • 310 citations

A Prospective Study of Cigarette Smoking and the Risk of Pancreatic Cancer

1996 • 306 citations

LIFE-STYLE RISK FACTORS FOR PANCREATIC CANCER IN LOUISIANA: A CASE-CONTROL STUDY

1988 • 300 citations

The natural history of hereditary pancreatitis: a national series

2008 • 285 citations

Predictors of pancreatic cancer mortality among a large cohort of United States adults.

2000 • 275 citations

Genetic, Immunohistochemical, and Clinical Features of Medullary Carcinoma of the Pancreas

2000 • 274 citations

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

2004 • 269 citations

Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas

2001 • 267 citations

Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family

2004 • 267 citations

The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer

2007 • 266 citations

Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.

1998 • 265 citations

Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families

1996 • 261 citations

STK11/LKB1 Peutz-Jeghers Gene Inactivation in Intraductal Papillary-Mucinous Neoplasms of the Pancreas

2001 • 260 citations

Risk of Pancreatic Adenocarcinoma in Patients With Hereditary Pancreatitis: A National Exhaustive Series

2008 • 256 citations

Fanconi anemia gene mutations in young-onset pancreatic cancer.

2003 • 253 citations

A Major Quantitative-Trait Locus for Mole Density Is Linked to the Familial Melanoma Gene CDKN2A: A Maximum-Likelihood Combined Linkage and Association Analysis in Twins and Their Sibs

1999 • 246 citations

Hamartomatous polyposis syndromes

2007 • 244 citations

Familial pancreatic cancer: a review.

1996 • 236 citations

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer

2003 • 235 citations

Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations.

2000 • 230 citations

Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma–pancreatic carcinoma–prone families

2001 • 227 citations

Pancreatitis and Pancreatic Cancer: a Population-Based Study

1994 • 211 citations

Palladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism

2006 • 210 citations

Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients

2009 • 204 citations

PancPRO: Risk Assessment for Individuals With a Family History of Pancreatic Cancer

2007 • 203 citations

BRCA Germline Mutations in Jewish Patients With Pancreatic Adenocarcinoma

2008 • 201 citations

Family history and the risk of liver, gallbladder, and pancreatic cancer.

1994 • 198 citations

Pancreatic carcinoma and hereditary nonpolyposis colorectal cancer: A family study

1985 • 198 citations

Reported family aggregation of pancreatic cancer within a population-based case-control study in the francophone community in Montreal, Canada

1991 • 197 citations

The hereditary pancreatitis gene maps to long arm of chromosome 7

1996 • 194 citations

Genetics of Pancreatic Cancer

1998 • 193 citations

Gain-of-Function Mutations Associated with Hereditary Pancreatitis Enhance Autoactivation of Human Cationic Trypsinogen

2000 • 191 citations

Risk Factors for Pancreatic Cancer: An Exploratory Study

1993 • 189 citations

Fibrosis of the pancreas: the initial tissue damage and the resulting pattern

2003 • 182 citations

Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.

2001 • 174 citations

Chronic pancreatitis, pseudotumors and other tumor-like lesions

2007 • 172 citations

Systemic cancer and the FAMMM syndrome

1990 • 167 citations

Human Cationic Trypsinogen

2000 • 164 citations

Familial Risk of Pancreatic Cancer

2001 • 158 citations

In vivoTherapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor

2005 • 152 citations

Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis

1995 • 152 citations

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency

2005 • 149 citations

Pancreatic Cancer Genetic Epidemiology Consortium

2006 • 142 citations

Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

2010 • 140 citations

Pancreatic cancer and the FAMMM syndrome

2007 • 135 citations

Risk factors for pancreatic cancer: A case-control study based on direct interviews

2000 • 134 citations

Prognostic value of microsatellite instability in resectable pancreatic cancer.

2002 • 132 citations

Familial pancreatic cancer

1999 • 130 citations

Screening and surveillance for hereditary pancreatic cancer

2002 • 130 citations

Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis

2006 • 129 citations

Evidence for a major gene influencing risk of pancreatic cancer

2002 • 128 citations

Cigarette smoking and cancer of the pancreas: Evidence from a population‐based case‐control study in Toronto, Canada

1991 • 127 citations

Familial melanoma, pancreatic cancer and germline CDKN2A mutations

2004 • 127 citations

A New Susceptibility Locus for Autosomal Dominant Pancreatic Cancer Maps to Chromosome 4q32-34

2002 • 126 citations

Familial and second primary pancreatic cancers: A nationwide epidemiologic study from Sweden

2002 • 124 citations

Familial pancreatic cancer: clinicopathologic study of 18 nuclear families.

1990 • 121 citations

Validity of Models for Predicting BRCA1 and BRCA2 Mutations

2007 • 121 citations

Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)

2003 • 116 citations

Loss of Stk11/Lkb1 Expression in Pancreatic and Biliary Neoplasms

2003 • 115 citations

Cancer in peutz-jeghers syndrome

1993 • 111 citations

Pancreatic Cancer and the Familial Atypical Multiple Mole Melanoma (FAMMM) Syndrome

1991 • 110 citations

A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals.

1996 • 105 citations

Intraductal papillary and mucinous pancreatic tumour: a new extracolonic tumour in familial adenomatous polyposis

2002 • 97 citations

BayesMendel: an R Environment for Mendelian Risk Prediction

2004 • 89 citations

Adenocarcinoma of the Pancreas in Four Siblings

1973 • 87 citations

The Genetics ofFANCCandFANCGin Familial Pancreatic Cancer

2004 • 80 citations

Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature

1987 • 78 citations

Prospective risk of cancer in CDKN2A germline mutation carriers

2004 • 76 citations

Neoplastic diseases in families of breast cancer patients.

1994 • 75 citations

Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene

2006 • 70 citations

A prospective study of cigarette smoking and the risk of pancreatic cancer

1996 • 69 citations

Familial Fibrocystic Pancreatic Atrophy With Endocrine Cell Hyperplasia and Pancreatic Carcinoma

2001 • 68 citations

Elevated Cancer Mortality in the Relatives of Patients with Pancreatic Cancer

2009 • 67 citations

Familial pancreatic adenocarcinoma: association with diabetes and early molecular diagnosis.

1995 • 66 citations

Identification of HNPCC by Molecular Analysis of Colorectal and Endometrial Tumors

2004 • 62 citations

Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells

2007 • 59 citations

ALLERGIC REACTIONS TO BITING INSECTS

1974 • 56 citations

Absence of germline BRCA1 mutations in familial pancreatic cancer patients

2009 • 55 citations

Hereditary Pancreatitis

1968 • 54 citations

Genetics and Pancreatic Cancer

1994 • 51 citations

Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer

1995 • 50 citations

Two-locus linkage analysis of cutaneous malignant melanoma/dysplastic nevi.

1996 • 50 citations

Evaluation of the 4q32-34 Locus in European Familial Pancreatic Cancer

2006 • 49 citations

Gene conversion cetween functional trypsinogen genesPRSS1andPRSS2associated with chronic pancreatitis in a six-year-old girl

2005 • 48 citations

Familial Pancreatic Cancer

1992 • 48 citations

[Peutz-Jeghers syndrome].

1976 • 48 citations

The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer

2007 • 48 citations

The inherited genetics of pancreatic cancer and prospects for secondary screening

2006 • 48 citations

A Familial Aggregation of Pancreatic Cancer

1982 • 40 citations

Targeting Fanconi Anemia/BRCA2 Pathway Defects in Cancer: The Significance of Preclinical Pharmacogenomic Models

2007 • 40 citations

Pharmacological evidence for histamine H3 receptor in the control of gastric acid secretion in cats

1991 • 39 citations

Heterogeneity of risk for melanoma and pancreatic and digestive malignancies

2004 • 37 citations

Familial Pancreatic Cancer and the Genetics of Pancreatic Cancer

1995 • 37 citations

Linkage analysis of chromosome 4 in families with familial pancreatic cancer

2007 • 30 citations

Familial pancreatic cancer in South Louisiana

1996 • 28 citations

BRCA1 and BRCA2 Mutations in Breast and Ovarian Cancer Syndrome: Reflection on the Creighton University Historical Series of High Risk Families

2006 • 24 citations

Patient Perspective on the Value of Genetic Counselling for Familial Pancreas Cancer

2005 • 24 citations

Cancer of the pancreas in two brothers and one sister

1987 • 24 citations

Association of Family History of Specific Cancers With a Younger Age of Onset of Pancreatic Adenocarcinoma

2006 • 23 citations

Medical Genetic Study of Eight Pancreatic Cancer-Prone Families

1995 • 22 citations

Carcinoma of the pancreas in four brothers.

1976 • 19 citations

Molecular genetics of intraductal papillary–mucinous neoplasms of the pancreas

2007 • 17 citations

Risk Modeling in Breast Cancer

2004 • 12 citations

A familial aggregation of pancreatic cancer. An in vitro study

1982 • 11 citations

Trypsinogen Mutations in Pancreatic Disorders

2006 • 10 citations

Structural classification of endogenous regulatory oligopeptides.

1991 • 9 citations

Overview of Linkage Analysis: Application to Pancreatic Cancer

2004 • 4 citations