Trypsinogen Mutations in Pancreatic Disorders

Pancreatitis and the Risk of Pancreatic Cancer

1993 • 1,714 citations

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

1996 • 1,600 citations

Chronic pancreatitis: Diagnosis, classification, and new genetic developments

2001 • 1,207 citations

Hereditary Pancreatitis and the Risk of Pancreatic Cancer

1997 • 968 citations

Clinical and genetic characteristics of hereditary pancreatitis in Europe

2004 • 603 citations

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

2000 • 553 citations

Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

1997 • 479 citations

The Complete 685-Kilobase DNA Sequence of the Human β T Cell Receptor Locus

1996 • 434 citations

Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

2000 • 353 citations

Cigarette Smoking as a Risk Factor for Pancreatic Cancer in Patients With Hereditary Pancreatitis

2001 • 319 citations

Hereditary pancreatitis: new insights into acute and chronic pancreatitis

1999 • 278 citations

A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

1999 • 260 citations

Ethanol toxicity in pancreatic acinar cells: Mediation by nonoxidative fatty acid metabolites

2004 • 206 citations

Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis.

1999 • 199 citations

Gain-of-Function Mutations Associated with Hereditary Pancreatitis Enhance Autoactivation of Human Cationic Trypsinogen

2000 • 191 citations

Human Cationic Trypsinogen

2000 • 164 citations

Risk of Pancreatic Carcinoma in Tropical Calcifying Pancreatitis

1994 • 162 citations

Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation

2000 • 157 citations

Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin Inhibitors

2003 • 148 citations

Hereditary Pancreatitis Caused by a Novel PRSS1 Mutation (Arg-122 → Cys) That Alters Autoactivation and Autodegradation of Cationic Trypsinogen

2002 • 127 citations

Presence of Cathepsin B in the Human Pancreatic Secretory Pathway and Its Role in Trypsinogen Activation during Hereditary Pancreatitis

2002 • 123 citations

Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene

2001 • 122 citations

Extracellular Cleavage of E-Cadherin by Leukocyte Elastase During Acute Experimental Pancreatitis in Rats

2005 • 117 citations

Evolution of Trypsinogen Activation Peptides

2003 • 113 citations

Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis

2002 • 98 citations

Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis

1999 • 97 citations

Human anionic trypsinogen

2003 • 90 citations

Pancreatitis as a risk for pancreatic cancer

2002 • 83 citations

Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants1

2002 • 81 citations

Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitis

2001 • 75 citations

Interaction between trypsinogen isoforms in genetically determined pancreatitis: Mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)

2003 • 67 citations

Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins

2001 • 67 citations

Is tropical pancreatitis premalignant?

1992 • 59 citations

Human Mesotrypsin Defies Natural Trypsin Inhibitors: From Passive Resistance to Active Destruction.

2005 • 57 citations

A new polymorphism for the RI22H mutation in hereditary pancreatitis

2001 • 56 citations

Early events in acute pancreatitis

2004 • 55 citations

“Loss of function” mutations in the cationic trypsinogen gene (PRSS1) may act as a protective factor against pancreatitis

2003 • 50 citations

Gene conversion cetween functional trypsinogen genesPRSS1andPRSS2associated with chronic pancreatitis in a six-year-old girl

2005 • 48 citations

Lack of R117H Mutation in the Cationic Trypsinogen Gene in Patients with Tropical Pancreatitis from Bangladesh

1998 • 47 citations

Spontaneous and Sporadic Trypsinogen Mutations in Idiopathic Pancreatitis

2002 • 40 citations

Spontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis.

2002 • 34 citations

Cathepsin B cleavage of the trypsinogen activation peptide

2002 • 30 citations

The Pathobiochemistry of Hereditary Pancreatitis: Studies on Recombinant Human Cationic Trypsinogen

2001 • 26 citations

Idiopathic Pancreatitis Related to CFTR: Complex Inheritance and Identification of a Modifier Gene

2002 • 24 citations

Idiopathic Pancreatitis Related to CFTR: Complex Inheritance and Identification of a Modifier Gene

2002 • 23 citations

Origin and implication of the hereditary pancreatitis-associated N21I mutation in the cationic trypsinogen gene

2000 • 21 citations

Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants

2002 • 18 citations

Expression of mutated cationic trypsinogen reduces cellular viability in AR4-2J cells

2005 • 17 citations

Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen

2005 • 15 citations