Retinoid Induced Apoptosis in Leukemia Cells Through a Retinoic Acid Nuclear Receptor-Independent Pathway

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

The molecular biology of apoptosis.

1996 • 963 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

Retinoic Acid Receptors and Cellular Retinoid Binding Proteins: Complex Interplay in Retinoid Signaling*

1994 • 514 citations

Retinoids in cancer therapy.

1992 • 505 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO

1991 • 432 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

The molecular biology of apoptoseis.

1996 • 390 citations

All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia [see comments]

1995 • 379 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Retinoids and vertebrate development.

1994 • 321 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines

1995 • 247 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.

1995 • 229 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin.

1993 • 210 citations

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ

1992 • 205 citations

p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.

1995 • 197 citations

Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

1994 • 196 citations

Levels of p53 protein increase with maturation in human hematopoietic cells.

1991 • 191 citations

Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity

1992 • 190 citations

Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines.

1995 • 162 citations

Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.

1995 • 148 citations

Retinoids and Cancer

1984 • 143 citations

Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function

1993 • 126 citations

Synthesis, Structure-Affinity Relationships, and Biological Activities of Ligands Binding to Retinoic Acid Receptor Subtypes

1995 • 122 citations

MINIREVIEW: Interactions of Retinoids and Transforming Growth Factor-β in Regulation of Cell Differentiation and Proliferation

1991 • 118 citations

Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells.

1992 • 100 citations

Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast carcinoma cells.

1996 • 89 citations

Interaction of Retinoids and Tamoxifen on the Inhibition of Human Mammary Carcinoma Cell Proliferation

1987 • 84 citations

Estradiol induction of retinoic acid receptors in human breast cancer cells.

1993 • 81 citations

Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis.

1995 • 77 citations

Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL.

1996 • 72 citations

Irradiation Induces WAF1 Expression through a p53-independent Pathway in KG-1 Cells

1995 • 71 citations

The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1.

1993 • 69 citations

Estrogen receptor‐negative breast cancer cells transfected with the estrogen receptor exhibit increased RARα gene expression and sensitivity to growth inhibition by retinoic acid

1993 • 67 citations

Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer

1994 • 40 citations

Retinoic acid receptors in myeloid leukemia: characterization of receptors in retinoic acid-resistant K-562 cells

1991 • 34 citations

Retinoic Acid Inhibition of Insulin-like Growth Factor I Stimulation of c-fos mRNA Levels in a Breast Carcinoma Cell Line

1994 • 26 citations

Deleted Work

1955 • 0 citations