Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Mismatch Repair, Genetic Stability, and Cancer

1994 • 429 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus.

1994 • 247 citations

Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene.

1991 • 195 citations

The p53 tumor suppressor protein: meeting review.

1993 • 128 citations

Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.

1995 • 107 citations

Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA

1994 • 63 citations

Gene Transfer to Freshly Isolated Human Respiratory Epithelial CellsIn VitroUsing a Replication-Deficient Adenovirus Containing the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA

1994 • 48 citations

Report of a Meeting; Molecular Basis of Cancer Therapy

1994 • 21 citations

Debris compensation of Dna histograms and its effect on S‐phase analysis

1995 • 20 citations

Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.

1994 • 17 citations