Mitogenic signalling by δ opioid receptors expressed in Rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

1996 • 490 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Opioid receptor-coupled second messenger systems

1991 • 466 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors

1995 • 267 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Multiple Independent Inputs Are Required for Activation of the p70 S6 Kinase

1995 • 234 citations

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression

1994 • 233 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

1994 • 207 citations

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1994 • 202 citations

Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.

1988 • 184 citations

Rapamycin, Wortmannin, and the Methylxanthine SQ20006 Inactivate p70s6k by Inducing Dephosphorylation of the Same Subset of Sites

1995 • 168 citations

A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol

1994 • 148 citations

Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.

1994 • 123 citations

Sequestration of a G-protein βγ Subunit or ADP-ribosylation of Rho Can Inhibit Thrombin-induced Activation of Platelet Phosphoinositide 3-Kinases

1995 • 93 citations

A Direct Interaction between G-Protein βγ Subunits and the Raf-1 Protein Kinase

1995 • 93 citations

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

1996 • 80 citations

Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways

1996 • 69 citations

Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.

1991 • 68 citations

Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6.

1990 • 57 citations

How does the G protein, G_i2, transduce mitogenic signals?

1994 • 56 citations

p70s6k/p85s6k: mechanism of activation and role in mitogenesis.

1994 • 56 citations

Analysis of inverse agonism at the δ opioid receptor after expression in Rat 1 fibroblasts

1996 • 50 citations

Wortmannin-sensitive Activation of p70 by Endogenous and Heterologously Expressed G -coupled Receptors

1996 • 46 citations

Regulation of p42 and p44 Map Kinase Isoforms in Rat-1 Fibroblasts Stably Transfected with α2C10 Adrenoceptors

1994 • 13 citations

EGF-Induced Activation of 70-kDa S6 Kinase in CHO Cells Expressing Human EGF Receptors

1995 • 10 citations