Hydrogen peroxide-induced expression of the proto-oncogenes, c-jun, c-fos and c-myc in rabbit lens epithelial cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

Oxidative stress‐induced cataract: mechanism of action

1995 • 891 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

Hydrogen peroxide and human cataract

1981 • 497 citations

Apoptosis and the cell cycle

1995 • 431 citations

Differential regulation of antioxidant enzymes in response to oxidants.

1991 • 411 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals.

1995 • 384 citations

The role of c-myc in cell growth

1993 • 365 citations

Apoptosis and the cell cycle

1995 • 334 citations

Bacterial defenses against oxidative stress

1990 • 316 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Transcriptional activation of early‐response genes by hydrogen peroxide in a mouse osteoblastic cell line

1991 • 298 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

myc Family Oncogenes in the Development of Normal and Neoplastic Cells

1991 • 245 citations

Redox redux: The control of oxidative stress responses

1991 • 242 citations

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

1990 • 226 citations

Light-induced damage to ocular lens cation pump: prevention by vitamin C.

1979 • 225 citations

Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1

1990 • 221 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Regulation of hydrogen peroxide in eye humors effect of 3-amino-1H-1,2,4-triazole on catalase and glutathione peroxidase of rabbit eye

1977 • 201 citations

Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells.

1983 • 178 citations

Studies on the Oxidation of Cysteine to Cystine in Lens Proteins During Cataract Formation*

1951 • 177 citations

[35] Hydrogen peroxide in hepatic microsomes

1978 • 169 citations

Role of [Ca ²⁺ ] _i in induction of c‐ fos , c‐ jun and c‐ myc mRNA in rat PTE after oxidative stress

1992 • 168 citations

Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract

1996 • 163 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Nucleotide sequence comparison of normal and translocated murine c-myc genes

1984 • 154 citations

A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins.

1994 • 146 citations

Rapid and Preferential Activation of the c-jun Gene during the Mammalian UV Response

1991 • 120 citations

Oxidants stress induces the proto-oncogenes, C-fos and C-myc in mouse epidermal cells.

1990 • 109 citations

H2O2-induced uncoupling of bovine lens Na+,K+-ATPase.

1983 • 108 citations

Retention of lens specificity in long-term cultures of diploid rabbit lens epithelial cells

1986 • 107 citations

Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells

1990 • 88 citations

Oxidative modification of lens crystallins by H2O2 and chelated iron

1989 • 86 citations

Identification of Residues in the Human DNA Repair Enzyme HAP1 (Ref-1) That are Essential for Redox Regulation of Jun DNA Binding

1993 • 84 citations

Evidence for positive and negative regulation in the promoter of the chicken δ1-crystallin gene

1988 • 81 citations

Peroxide-induced effects on lens cation transport following inhibition of glutathione reductase activity in vitro

1987 • 73 citations

Interaction between two different regulatory elements activates the murine alpha A-crystallin gene promoter in explanted lens epithelia.

1987 • 58 citations

Regulation of protooncogenes c-fos and c-myc expressions by protein tyrosine kinase, protein kinase C, and cyclic AMP mitogenic pathways in dog primary thyrocytes: A positive and negative control by cyclic AMP on c-myc expression

1990 • 57 citations

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

1995 • 57 citations

The nature and origin of the urea-insoluble protein of human lens

1972 • 57 citations

The effects of “oxygen radicals” generated in the medium on lenses in organ culture: Inhibition of damage by chelated iron

1985 • 56 citations

The Redox Active Components H202 and N-AcetyI-L-Cysteine Regulate Expression of c-jun and c-fos in Lens Systems

1994 • 54 citations

Oxidant Stress Leads to Transcriptional Activation of the Human Heme Oxygenase Gene in Cultured Skin Fibroblasts

1990 • 53 citations

Expression of c-fos and c-jun mRNA in the developing chicken lens: Relationship to cell proliferation, quiescence, and differentiation

1992 • 52 citations

c-myc mRNA is elevated as differentiating lens cells withdraw from the cell cycle

1987 • 45 citations

Photochemically induced cataracts in rat lenses can be prevented by AL-3823A, a glutathione peroxidase mimic.

1993 • 38 citations

Contrasting patterns of c-myc and N-myc expression in proliferating, quiescent, and differentiating cells of the embryonic chicken lens

1992 • 37 citations

Complete nucleotide sequence of the chicken αA-crystallin gene and its 5' flanking region

1987 • 36 citations

Structure and lens expression of the gene encoding chicken βA3/A1-crystallin

1992 • 27 citations

30 Dangerous Liaisons: Fos and Jun, Oncogenic Transcription Factors

1992 • 25 citations

The two duplicated insecticyanin genes,ins-aandins-bare differentially expressed in the tobacco hornworm,Manduca sexta

1994 • 24 citations

Interaction Between two Different Regulatory Elements Activates the Murine α A-Crystallin Gene Promoter in Explanted Lens Epithelia

1987 • 16 citations

Differential Expression of c‐myc and N‐myc during Oral Organogenesis of the Mouse Embryo

1992 • 11 citations

Effects of c‐Jun and a negative dominant mutation of c‐Jun on differentiation and gene expression in lens epithelial cells

1995 • 10 citations

Expression of c-myc protooncogene in rat lens cells during development, maturation and reversal of galactose cataracts

1992 • 10 citations

Regulation of expression of c-myc protooncogene in a clonal line of mouse lens epithelial cells by serum growth factors

1989 • 6 citations