BTK the tyrosine kinase affected in X-linked agammaglobulinemia

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

The Primary Immunodeficiencies

1984 • 1,111 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Chronic Enteroviral Meningoencephalitis in Agammaglobulinemic Patients

1987 • 458 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

X-Linked Agammaglobulinemia

1985 • 415 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Signal transduction by Fc receptors: the Fc&RI case

1993 • 373 citations

2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1993 • 356 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

PH domain: the first anniversary

1994 • 318 citations

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1994 • 310 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes

1995 • 286 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

Structure of the binding site for inositol phosphates in a PH domain.

1995 • 281 citations

cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

1994 • 279 citations

X-Linked Agammaglobulinemia A Clinical and Molecular Analysis

1996 • 259 citations

Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

1995 • 257 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1994 • 256 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

1996 • 250 citations

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1994 • 247 citations

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.

1994 • 221 citations

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

1993 • 208 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Activation of bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

1995 • 191 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.

1994 • 178 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

1994 • 169 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

BTKbase, mutation database for X-linked agammaglobulinemia (XLA)

1998 • 155 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Molecular and Cellular Aspects of X-Linked Agammaglobulinemia

1995 • 148 citations

Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.

1993 • 142 citations

Eukaryotic protein kinases

1991 • 140 citations

A novel protein-tyrosine kinase, tec, is preferentially expressed in liver.

1990 • 139 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

1995 • 131 citations

Domain movements in protein kinases

1994 • 129 citations

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

1995 • 127 citations

Structure-Function Analysis of SH3 Domains: SH3 Binding Specificity Altered by Single Amino Acid Substitutions

1995 • 126 citations

Structural Characterization of the Interaction between a Pleckstrin Homology Domain and Phosphatidylinositol 4,5-Bisphosphate

1995 • 125 citations

X-Linked Immune Deficiency (xid) of CBA/N Mice

1986 • 123 citations

Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane

1995 • 122 citations

Crystal structure of the pleckstrin homology domain from dynamin

1994 • 120 citations

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

1996 • 117 citations

X‐Linked Agammaglobulinemia and Other Immunoglobulin Deficiencies

1994 • 113 citations

Tec homology (TH) adjacent to the PH domain

1994 • 110 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

Pleckstrin homology domains: a fact file

1995 • 101 citations

Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.

1994 • 100 citations

Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins.

1995 • 100 citations

Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain Function

1993 • 99 citations

Primary sequence and developmental expression of a novel Drosophila melanogaster src gene.

1987 • 98 citations

Solution structure and peptide binding of the SH3 domain from human Fyn

1996 • 95 citations

Identification of Rlk, a Novel Protein Tyrosine Kinase with Predominant Expression in the T Cell Lineage

1995 • 92 citations

Three-dimensional solution structure of the pleckstrin homology domain from dynamin

1994 • 92 citations

BTKbase: a database of XLA-causing mutations

1995 • 90 citations

Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

1995 • 90 citations

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy.

1995 • 88 citations

CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction

1995 • 87 citations

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

1994 • 87 citations

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

1994 • 86 citations

Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.

1994 • 85 citations

DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia

1995 • 85 citations

2.0 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent

1993 • 73 citations

IL-5 receptor positive B cells, but not eosinophils, are functionally and numerically influenced in mice carrying the X-linked immune defect

1993 • 68 citations

Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 kDa protein: characterization of the determinants of structural specificity

1996 • 65 citations

Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinase

1988 • 63 citations

Structural Basis for Pleckstrin Homology Domain Mutations in X-Linked Agammaglobulinemia

1995 • 61 citations

Identification of a closely linked DNA marker, DXS178, to further refine the X-linked agammaglobulinemia locus

1990 • 61 citations

Close linkage of probe p212 (DXS178) to X-linked agammaglobulinemia

1989 • 60 citations

The Pleckstrin Homology Domain of Human βIΣII Spectrin Is Targeted to the Plasma Membranein Vivo

1996 • 59 citations

Identification of Btk mutations in 20 unrelated patients with X-Iinked agammaglobulinaemia (XLA)

1995 • 58 citations

B cells from CBA/N mice do not proliferate following ligation of CD40

1994 • 55 citations

An SH3-binding Site Conserved in Bruton's Tyrosine Kinase and Related Tyrosine Kinases Mediates Specific Protein Interactions in Vitro and in Vivo

1995 • 55 citations

Structural Studies on the PH Domains of Dbl, Sos1, IRS-1, and .beta.ARK1 and Their Differential Binding to G.beta..gamma. Subunits

1995 • 50 citations

A novel human tyrosine kinase gene inducible in T cells by interleukin 2

1993 • 48 citations

BTKbase: XLA-mutation registry

1996 • 46 citations

The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.

1996 • 45 citations

Structural Basis of SH2 Domain Mutations in X-Linked Agammaglobulinemia

1994 • 45 citations

Molecular cloning and analysis of the human Tec protein-tyrosine kinase.

1994 • 44 citations

Induction of costimulatory molecules B7-1 and B7-2 in murine B cells: The CBAN mouse reveals a role for Bruton's tyrosine kinase in CD40-mediated B7 induction

1996 • 35 citations

Tec protein-tyrosine kinase directly associates with Lyn protein-tyrosine kinase through its N-terminal unique domain.

1994 • 34 citations

3. Molecular Basis for X-Linked Immunodeficiencies

1997 • 28 citations

Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot

1995 • 27 citations

Structural Aspects of Signal Transduction in B-Cells

1996 • 26 citations

Structural basis for X-linked agammaglobulinemia (XLA): mutations at interacting Btk residues R562, W563, and A582

1995 • 11 citations