Structural basis for X-linked agammaglobulinemia (XLA): mutations at interacting Btk residues R562, W563, and A582

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

The Primary Immunodeficiencies

1984 • 288 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Expression of the Gene Defect in X-Linked Agammaglobulinemia

1986 • 177 citations

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

1994 • 169 citations

Carrier Detection in X-Linked Agammaglobulinemia by Analysis of X-Chromosome Inactivation

1987 • 159 citations

Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.

1993 • 142 citations

Eukaryotic protein kinases

1991 • 140 citations

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice

1994 • 131 citations

Structure and Expression of Novel Protein-Tyrosine Kinases, EMB and EMT, in Hematopoietic Cells

1993 • 131 citations

A Point Mutation in the SH2 Domain of Bruton's Tyrosine Kinase in Atypical X-Linked Agammaglobulinemia

1994 • 129 citations

X‐Linked Agammaglobulinemia and Other Immunoglobulin Deficiencies

1994 • 113 citations

Tec homology (TH) adjacent to the PH domain

1994 • 110 citations

Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis

1994 • 101 citations

Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain Function

1993 • 99 citations

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

1994 • 87 citations

DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia

1995 • 85 citations

Diagnosis and Treatment of Immunodeficiency Diseases

1981 • 76 citations

Genomic organization of the Btk gene and exon scanning for mutations in patients with X-linked agammaglobulinemia

1994 • 71 citations

Diagnosis and Treatment of Immunodeficiency Diseases

1981 • 34 citations

Improved oligonucleotide primer set for molecular diagnosis of X-linked agammaglobulinaemia: predominance of amino acid substitutions in the catalytic domain of Bruton's tyrosine kinase

1995 • 32 citations

Deleted Work

1955 • 0 citations