Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Assessment of protein models with three-dimensional profiles

1992 • 3,317 citations

Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome

1991 • 1,601 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Reaction mechanism of alkaline phosphatase based on crystal structures

1991 • 930 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

1981 • 363 citations

2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1993 • 356 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells.

1994 • 301 citations

cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

1994 • 279 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

Refined structure of alkaline phosphatase from Escherichia coli at 2.8 Å resolution

1985 • 233 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Molecular pathology of haemophilia B.

1989 • 178 citations

Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.

1986 • 156 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.

1993 • 142 citations

Molecular Approaches to Analysis of X-Linked Immunodeficiencies

1992 • 139 citations

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice

1994 • 131 citations

A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity.

1985 • 126 citations

Structural Basis of the Intrasteric Regulation of Myosin Light Chain Kinases

1992 • 117 citations

Polarity as a criterion in protein design

1989 • 110 citations

Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis

1994 • 101 citations

Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain Function

1993 • 99 citations

Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor.

1993 • 84 citations

A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity.

1986 • 80 citations

Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation.

1985 • 79 citations

Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum.

1990 • 77 citations

2.0 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent

1993 • 73 citations

Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation

1993 • 66 citations

A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites.

1993 • 62 citations

Selection of a representative set of structures from brookhaven protein data bank

1992 • 58 citations

Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).

1993 • 55 citations

Neither Arginine nor Histidine Can Carry Out the Function of Lysine-295 in the ATP-Binding Site of p60^src

1986 • 43 citations

A Mutation at the ATP-Binding Site of pp60^v-src Abolishes Kinase Activity, Transformation, and Tumorigenicity

1985 • 39 citations

Isolation of Cosmid and cDNA Clones in the Region Surrounding the BTK Gene at Xq21.3-q22

1994 • 38 citations

Developmentally Regulated Protein-Tyrosine Kinase Genes in Dictyostelium discoideum

1990 • 29 citations

MULTICOMP: a program package for multiple sequence comparison

1992 • 15 citations

A Three-Dimensional Model of the Cdc2 Protein Kinase: Localization of Cyclin- and Suc1-Binding Regions and Phosphorylation Sites

1993 • 14 citations