Transplantation tolerance—where do we stand?

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

1992 • 737 citations

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

1968 • 668 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

1968 • 639 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys

1995 • 552 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

1997 • 373 citations

Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

1998 • 352 citations

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

1986 • 344 citations

Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice

1995 • 340 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

1997 • 317 citations

Induction of tolerance by monoclonal antibody therapy

1986 • 307 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

The lost chord: microchimerism and allograft survival

1996 • 259 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

Cellular Sites of Immunologic Unresponsiveness

1970 • 202 citations

Linked suppression of skin graft rejection can operate through indirect recognition.

1998 • 175 citations

AMPLIFICATION OF NATURAL REGULATORY IMMUNE MECHANISMS FOR TRANSPLANTATION TOLERANCE1

1996 • 161 citations

EFFECT OF ORGAN CULTURE ON THE SURVIVAL OF THYROID ALLOGRAFTS IN MICE

1976 • 159 citations

Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

1999 • 159 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Cutting Edge: Linked Suppression of Skin Graft Rejection Can Operate Through Indirect Recognition

1998 • 138 citations

The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat

1999 • 133 citations

Induction of Specific T Cell Tolerance by Fas Ligand- Expressing Antigen-Presenting Cells

1999 • 131 citations

Induction of immune tolerance by administration of monoclonal antibody to L3T4.

1986 • 127 citations

ADDITIONAL MONOCLONAL ANTIBODY (mAB) INJECTIONS CAN REPLACE THYMIC IRRADIATION TO ALLOW INDUCTION OF MIXED CHIMERISM AND TOLERANCE IN MICE RECEIVING BONE MARROW TRANSPLANTATION AFTER CONDITIONING WITH ANTI-T CELL mABs AND 3-GY WHOLE BODY IRRADIATION1

1996 • 126 citations

SKIN ALLOGRAFT REJECTION BY L3/t4+ AND LYT-2+ T CELL SUBESTS

1986 • 119 citations

Analysis of T-cell subsets in rejection of Kb mutant skin allografts differing at class I MHC

1986 • 114 citations

Bone Marrow Transplantation Induces Either Clonal Deletion or Infectious Tolerance Depending on the Dose

1998 • 101 citations

Functions of Purified L3T4⁺ and Lyt‐2⁺ Cells in vitro and in vivo

1986 • 92 citations

REVERSAL OF NATURALLY OCCURRING DIABETES IN PRIMATES BY UNMODIFIED ISLET XENOGRAFTS WITHOUT CHRONIC IMMUNOSUPPRESSION1

1999 • 82 citations

Induction of peripheral CD8⁺ T‐cell tolerance by cross‐presentation of self antigens

1998 • 76 citations

Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression

1989 • 69 citations

In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help.

1990 • 63 citations

Classical transplantation tolerance in the adult: the interaction between myeloablation and immunosuppression

1992 • 59 citations

ANALYSIS OF PRIMATE RENAL ALLOGRAFTS AFTER T-CELL DEPLETION WITH ANTI-CD3-CRM91,2

1998 • 53 citations

Bone marrow chimerism and transplantation tolerance

1997 • 52 citations

T-cell subsets, bm mutants, and the mechanisms of allogeneic skin graft rejection

1989 • 36 citations

Use of allogenic, homozygous bone marrow cells for the induction of specific immunologic tolerance in mice treated with antilymphocyte serum.

1970 • 30 citations

Antilymphocyte serum, donor bone marrow and tolerance to allografts: the journey is the reward

1999 • 17 citations

The Zodiacal Light and Meteors

1888 • 2 citations