T-cell subsets, bm mutants, and the mechanisms of allogeneic skin graft rejection

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council.

1944 • 661 citations

TREATMENT OF ACUTE RENAL ALLOGRAFT REJECTION WITH OKT3 MONOCLONAL ANTIBODY

1981 • 389 citations

Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.

1986 • 229 citations

Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.

1981 • 211 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

Variable capacity of L3T4+ T cells to cause lethal graft-versus-host disease across minor histocompatibility barriers in mice.

1987 • 170 citations

B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.

1979 • 161 citations

MAINTENANCE OF SKIN XENOGRAFTS OF WIDELY DIVERGENT PHYLOGENETIC ORIGIN ON CONGENITALLY ATHYMIC (NUDE) MICE

1973 • 143 citations

Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice

1965 • 133 citations

SKIN ALLOGRAFT REJECTION BY L3/t4+ AND LYT-2+ T CELL SUBESTS

1986 • 119 citations

WHICH T CELLS MEDIATE ALLOGRAFT REJECTION?

1985 • 115 citations

Analysis of T-cell subsets in rejection of Kb mutant skin allografts differing at class I MHC

1986 • 114 citations

"Intrinsic" Immunological Tolerance in Allophenic Mice

1967 • 109 citations

Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.

1985 • 98 citations

Cells Mediating Allograft Rejection

1984 • 94 citations

The effect of anti-L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts.

1987 • 92 citations

The role of H-Y as a minor transplantation antigen

1982 • 91 citations

Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.

1986 • 90 citations

THE EFFECT OF ANTI-L3T4 MONOCLONAL ANTIBODY TREATMENT ON FIRST-SET REJECTION OF MURINE CARDIAC ALLOGRAFTS

1987 • 84 citations

Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.

1978 • 78 citations

Mechanisms of Allograft Rejection: The Roles of Cytotoxic T‐Cells and Delayed‐Type Hypersensitivity

1984 • 70 citations

Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo.

1984 • 69 citations

Administration of F(ab')2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells.

1986 • 67 citations

Kidney Transplant Rejection

1987 • 65 citations

In Vivo use of monoclonal antibodies against murine T cell antigens

1989 • 56 citations

A reexamination of the role of LYT-2-positive T cells in murine skin graft rejection.

1984 • 54 citations

Relationship among function, phenotype, and specificity in primary allospecific T cell populations: identification of phenotypically identical but functionally distinct primary T cell subsets that differ in their recognition of MHC class I and class II allodeterminants.

1987 • 46 citations

Effector cells in allelic H-2 class I-incompatible skin graft rejection.

1987 • 42 citations

History and genealogy of theH-2K b mutants from the C57BL/6Kh colony

1982 • 37 citations

PREVENTION OF ALLOANTIBODY FORMATION AFTER SKIN GRAFTING WITHOUT PROLONGATION OF GRAFT SURVIVAL

1988 • 35 citations

Influence of Langerhans Cells on the Survival of H-Y Incompatible Skin Grafts in Rats

1983 • 35 citations

Ia+ murine epidermal Langerhans cells are deficient in surface expression of the class I major histocompatibility complex.

1986 • 30 citations

THE ROLE OF T4+ AND LY-2+ CELLS IN SKIN GRAFT REJECTION IN THE MOUSE

1987 • 28 citations

Monoclonal antibody treatment of human allograft recipients.

1988 • 25 citations

Biochemical studies of H-2K antigens from a group of related mutants. I. Identification of a shared mutation in B6-H-2 bm5 and B6-H-2 bm16

1983 • 24 citations

REJECTION OF SKIN GRAFTS AND GENERATION OF CYTOTOXIC T CELLS BY MICE DEPLETED OF L3T4+ CELLS

1986 • 22 citations

Biochemical studies of H-2K antigens from a group of related mutants. II. Identification of a shared mutation in B6-H-2 bm6 , B6.C-H-2 bm7 , and B6.C-H-2 bm9

1983 • 21 citations

CELLULAR PATHWAYS FOR REJECTION OF CLASS-I-MHCDISPARATE SKIN AND TUMOR ALLOGRAFTS1

1988 • 20 citations

Differential helper and effector responses of Lyt-2+ T cells to H-2Kb mutant (Kbm) determinants and the appearance of thymic influence on anti-Kbm CTL responsiveness.

1986 • 13 citations

Murine cardiac allograft survival following treatment of recipients with monoclonal anti-L3T4 or Ly-2 antibodies.

1987 • 10 citations

SURVIVAL TIMES OF SKIN XENOGRAFTS IN MICE UNDER CHRONIC TREATMENT WITH ANTITHYMOCYTE SERUM IN DIFFERENT DOSAGE-TIMING SCHEDULES

1971 • 3 citations