Functions of Purified L3T4⁺ and Lyt‐2⁺ Cells in vitro and in vivo

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man

1981 • 871 citations

The H-2 Major Histocompatibility Complex and the/Immune Response Region: Genetic Variation, Function, and Organization

1975 • 774 citations

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

1975 • 758 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Two subsets of rat T lymphocytes defined with monoclonal antibodies

1980 • 678 citations

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes

1974 • 572 citations

Graft Versus Host Reactions. Their Natural History, and Applicability as Tools of Research

2015 • 550 citations

Identification of a membrane-associated interleukin 1 in macrophages.

1985 • 487 citations

Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice

1983 • 367 citations

Functions of Rat T‐Lymphocyte Subsets Isolated by Means of Monoclonal Antibodies

1983 • 330 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

A LYMPH NODE WEIGHT ASSAY FOR THE GRAFTVERSUS- HOST ACTIVITY OF RAT LYMPHOID CELLS

1970 • 312 citations

Monoclonal antibody against an Ir gene product?

1980 • 238 citations

Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.

1986 • 229 citations

Murine Lymphocyte Surface Antigens

1979 • 228 citations

The Origin and Mechanism of the Allograft Reaction

1977 • 217 citations

Quantitation and Cloning of Cytolytic T Lymphocytes and their Precursors

1980 • 213 citations

Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.

1981 • 211 citations

H-2 Mutations: Their Genetics and Effect on Immune Functions

1978 • 200 citations

Cellular Immunology and the Pathogenesis of Graft Versus Host Reactions1

2015 • 198 citations

SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE

1970 • 183 citations

Nucleotide sequence of mutant I-Aβbm12 gene is evidence for genetic exchange between mouse immune response genes

1984 • 178 citations

Graft Versus Host Reactions. Their Natural History, and Applicability as Tools of Research (Part 1 of 3)

1962 • 173 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.

1985 • 137 citations

Allosuppressor- and allohelper-T cells in acute and chronic graft-vs.-host (GVH) disease. III. Different Lyt subsets of donor T cells induce different pathological syndromes.

1983 • 135 citations

Antigen-driven helper cell-independent cloned cytolytic T lymphocytes

1981 • 128 citations

Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences.

1985 • 125 citations

The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.

1981 • 123 citations

Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers.

1982 • 121 citations

Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A.

1983 • 118 citations

GRAFT-VERSUS-HOST REACTION ACROSS DIFFERENT REGIONS OF THE H-2 COMPLEX OF THE MOUSE

1973 • 114 citations

Lymphocyte Reactivity to Serologically Undetected Components of the Major Histocompatibility Complex

1973 • 111 citations

T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.

1984 • 108 citations

Cellular Immunology and the Pathogenesis of Graft Versus Host Reactions (Part 1 of 3)

1971 • 102 citations

Interaction of thymus lymphocytes with histoincompatible cells. II. Recirculating lymphocytes derived from antigen-activated thymus cells

1972 • 98 citations

Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.

1985 • 98 citations

Antigenic Requirements for Triggering of Cytotoxic T Lymphocytes

1977 • 97 citations

Lethal GVHD Across Minor Histocompatibility Barriers: Nature of the Effector Cells and Role of the H‐2 Complex

1983 • 96 citations

H‐2 Restricted Cytolytic and Noncytolytic T Cell Clones: Isolation, Specificity and Functional Analysis

1981 • 95 citations

Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen.

1984 • 90 citations

Preparative nonlytic separation of Lyt2⁺ and Lyt2⁻ T lymphocytes, functional analyses of the separated cells and demonstration of synergy in graft‐vs.‐host reaction of Lyt2⁺ and Lyt2⁻ cells

1981 • 84 citations

SUBSETS OF T CELLS IN THE RAT MEDIATING LETHAL GRAFT-VERSUS-HOST DISEASE

1981 • 81 citations

Characterization of the stimulator cells in the murine primary mixed leukocyte response.

1980 • 78 citations

Interaction of thymus lymphocytes with histoincompatible cells. I. Quantitation of the proliferative response of thymus cells

1972 • 76 citations

Cloned cytolytic T cells can suppress primary cytotoxic responses directed against them.

1984 • 68 citations

Lyt-2- T cell-independent functions of Lyt-2+ cells stimulated with antigen or concanavalin A.

1984 • 59 citations

Graft-versus-host reactions in mice. I. Kinetic and immunogenetic studies of alloantigen-sensitive units of lymphoid tissue.

1971 • 56 citations

Capacity of purified Lyt-2+ T cells to mount primary proliferative and cytotoxic responses to Ia− tumour cells

1986 • 56 citations

Cytotoxic T cells both produce and respond to interleukin 2

1984 • 55 citations

Selective activation of Lyt 2+ precursor T cells by ligation of the antigen receptor

1985 • 51 citations

Capacity of small B cell‐enriched populations to stimulate mixed lymphocyte reactions: marked differences between irradiated vs. mitomycin C‐treated stimulators

1985 • 51 citations

Bone marrow transplantation across major histocompatability barriers in mice. III. Treatment of donor grafts with monoclonal antibodies directed against Lyt determinants.

1982 • 46 citations

Autonomously proliferating K/D‐restricted cytolytic T cell clones

1983 • 44 citations

Helper cell-independent cytolytic T lymphocytes specific for a minor histocompatibility antigen.

1983 • 40 citations

Ability of H-2 Regions to Induce Graft-vs-Host Disease

1976 • 39 citations

GRAFT-VERSUS-HOST REACTIONS IN MICE

1971 • 38 citations

Role of syngeneic Ia+ accessory cells in the generation of allospecific CTL responses.

1982 • 36 citations

The role of Ia molecules in the activation of T lymphocytes. II. Ia-restricted recognition of allo K/D antigens is required for class I MHC-stimulated mixed lymphocyte responses.

1983 • 36 citations

GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.

1985 • 34 citations

Analysis of the two-signal requirement for precursor cytolytic T lymphocyte activation using H-2Kk in liposomes.

1982 • 34 citations

Expression of both I-A and I-E/C subregion antigens on accessory cells required for in vitro generation of cytotoxic T lymphocytes against alloantigens or TNBS-modified syngeneic cells.

1980 • 32 citations

Acquisition of the T cell repertoire

1978 • 30 citations

Responses to the H–2Kba mutant involve recognition of syngeneic Ia molecules

1983 • 26 citations

Terminal differentiation of T cells specific for mutant H‐2K antigens. Conversion of Lyt‐1,2 cells into Lyt‐2 but not Lyt‐1 cells, in vitro

1981 • 17 citations

THE IMMUNOGENETICS OF THE MOUSE MAJOR HISTOCOMPATIBILITY GENE COMPLEX

1984 • 17 citations

Surface markers of cytotoxic T lymphocyte clones

1984 • 16 citations

Lyt phenotypes of alloreactive precursor and effector cytotoxic T lymphocytes.

1981 • 14 citations

Correlation of graft-versus-host mortality and positive CML assay in the mouse.

1976 • 13 citations

T-lymphocyte heterogeneity in the rat: Separation of distinct rat T-lymphocyte populations which respond in syngeneic and allogeneic mixed lymphocyte reactions

1984 • 12 citations

Subpopulations of T Cells in the Rat that Mediate Graft-Versus-Host Reactions and Lethal Graft-Versus-Host Disease

1982 • 7 citations

Different target antigens for T-cell subsets acting synergistically in vivo

1980 • 5 citations

Search for class II major histocompatibility complex molecular involvement in the response of Lyt‐2⁺cytotoxic T lymphocyte precursors to alloantigen

1985 • 5 citations