Anti-angiogenesis Therapy and Strategies for Integrating It with Adjuvant Therapy

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

1996 • 1,206 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

1996 • 886 citations

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

1997 • 841 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.

1997 • 832 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

1996 • 788 citations

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

1997 • 778 citations

Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation

1996 • 752 citations

Role of tissue factor in embryonic blood vessel development

1996 • 693 citations

Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo

1995 • 605 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

1997 • 485 citations

Quantitation and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chalkley count, and computer image analysis

1995 • 450 citations

Halting angiogenesis suppresses carcinoma cell invasion

1997 • 430 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Thymidine phosphorylase is angiogenic and promotes tumor growth.

1995 • 394 citations

Targeting gene expression to hypoxic tumor cells

1997 • 373 citations

Flk-1 as a target for tumor growth inhibition.

1996 • 321 citations

The fibronectin isoform containing the ed‐b oncofetal domain: A marker of angiogenesis

1994 • 306 citations

Kringle 5 of Plasminogen is a Novel Inhibitor of Endothelial Cell Growth

1997 • 294 citations

Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients

1997 • 288 citations

Vascular endothelial grouth facter B, a novel growth facter for endothelial cells

1996 • 279 citations

Enhancement of Tumor Growth and Vascular Density by Transfection of Vascular Endothelial Cell Growth Factor Into MCF-7 Human Breast Carcinoma Cells

1995 • 270 citations

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice.

1996 • 250 citations

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer

1997 • 244 citations

Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies.

1997 • 241 citations

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

1996 • 240 citations

Matrix metalloproteinase inhibition: A review of anti-tumour activity

1995 • 226 citations

Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells

1997 • 218 citations

Quantitative analysis of vascular endothelial growth factor in primary breast cancer

1996 • 199 citations

Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: Implications for tumor angiogenesis

1996 • 199 citations

Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis

1996 • 197 citations

2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Induces Apoptosis in Endothelial Cells and Inhibits Angiogenesis: Possible Role for Stress-Activated Protein Kinase Signaling Pathway and Fas Expression

1997 • 193 citations

The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.

1997 • 179 citations

Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents

1997 • 140 citations

Association of Tumor Angiogenesis With Bone Marrow Micrometastases in Breast Cancer Patients

1997 • 133 citations

Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas

1997 • 125 citations

Examining the technique of angiogenesis assessment in invasive breast cancer

1997 • 125 citations

Association between tumour angiogenesis and tumour cell shedding into effluent venous blood during breast cancer surgery

1995 • 109 citations

Leukocyte-endothelial adhesion and angiogenesis in tumors

1996 • 105 citations

The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor.

1997 • 99 citations

Angiogenesis in primary lung cancer and lung secondaries

1996 • 97 citations

Cell adhesion molecules in angiogenesis

1996 • 97 citations

Suramin is a Potent Inhibitor of Vascular Endothelial Growth Factor. A Contribution to the Molecular Basis of its Antiangiogenic Action

1996 • 88 citations

Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.

1997 • 88 citations

Human Breast Cancer Growth Inhibited in Vivo by a Dominant Negative Pleiotrophin Mutant

1997 • 83 citations

Effects of tamoxifen and interferon-β or the combination on tumor-induced angiogenesis

1997 • 77 citations

Markers of tumor angiogenesis: clinical applications in prognosis and anti-angiogenic therapy

1997 • 71 citations

Treating cancer by inhibiting angiogenesis: new hopes and potential pitfall

1996 • 69 citations

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF

1997 • 65 citations

Endothelial Cell-Specific Expression of Tumor Necrosis Factor-αfrom the KDR or E-Selectin Promoters Following Retroviral Delivery

1997 • 62 citations

Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomasin situ of the breast

1997 • 62 citations

Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential

1996 • 53 citations

Tumor targeting potential of the monoclonal antibody BC‐1 against oncofetal fibronectin in nude mice bearing human tumor implants

1997 • 52 citations

VEGF mRNA is Reversibly Stabilized by Hypoxia and Persistently Stabilized in VEGF-Overexpressing Human Tumor Cell Lines

1995 • 52 citations

Lactate stimulation of macrophage-derived angiogenic activity is associated with inhibition of Poly(ADP-ribose) synthesis.

1996 • 49 citations

Urokinase Plasminogen Activator Induces Angiogenesis and Tumor Vessel Invasion in Breast Cancer

1995 • 44 citations

Angiogenesis and cancer metastases: therapeutic approaches

1995 • 38 citations

Tumor targeting potential of the monoclonal antibody BC-1 against oncofetal fibronectin in nude mice bearing human tumor implants

1997 • 38 citations

Is a histological section representative of whole tumour vascularity in breast cancer?

1997 • 34 citations

Soluble E-selectin in cancer patients as a marker of the therapeutic efficacy of CM101, a tumor-inhibiting anti-neovascularization agent, evaluated in phase I clinical trial

1997 • 29 citations

The Internet Book of Gene Therapy: Cancer Therapeutics

1997 • 22 citations

Prognostic and Predictive Value of p53

1998 • 17 citations

Prolactins: Novel Regulators of Angiogenesis

1997 • 13 citations

The expression of antisense vascular endothelial growth factor (VEGF) sequences inhibits intracranial C6 glioma growth in vivo by suppressing tumour angiogenesis

1996 • 10 citations

Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: HYPOXIA‐ACTIVATED PRODRUGS AS ANTITUMOUR AGENTS: STRATEGIES FOR MAXIMIZING TUMOUR CELL KILLING

1995 • 9 citations