Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomasin situ of the breast

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Diagnostic Histopathology of the Breast

1988 • 1,083 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1989 • 726 citations

Prognostic classification of breast ductal carcinoma-in-situ

1995 • 678 citations

Ductal carcinoma in situ: a proposal for a new classification.

1994 • 537 citations

Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer

1994 • 404 citations

Thymidine phosphorylase is angiogenic and promotes tumor growth.

1995 • 394 citations

Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages.

1984 • 366 citations

Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells.

1984 • 339 citations

Microvessel Density and Distribution in Ductal Carcinoma In Situ of the Breast

1994 • 287 citations

Duct Carcinoma in Situ: Pathology and Treatment

1990 • 286 citations

Vascular Permeability Factor (Vascular Endothelial Growth Factor) Expression and Angiogenesis in Cervical Neoplasia

1995 • 285 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis

1990 • 253 citations

Demonstration and characterization of the angiogenic properties of cervical dysplasia.

1994 • 234 citations

Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer.

1993 • 209 citations

Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5?-deoxy-5-fluorouridine

1993 • 209 citations

Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity

1992 • 209 citations

Angiogenesis as a marker of preneoplastic lesions of the human breast

1978 • 199 citations

Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity

1992 • 198 citations

Platelet‐derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: An immunohistochemical study

1995 • 192 citations

Novel growth regulatory factors and tumour angiogenesis

1991 • 162 citations

Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia

1977 • 161 citations

The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium

1996 • 156 citations

Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin

1993 • 155 citations

Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers.

1996 • 151 citations

Secretion of epidermal growth factor by macrophages associated with breast carcinoma

1993 • 150 citations

Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer.

1988 • 146 citations

Ideas in pathology. Ductal carcinoma in situ of the breast: a proposal for a new simplified histological classification association between cellular proliferation and c-erbB-2 protein expression.

1994 • 135 citations

Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer.

1995 • 122 citations

Distinct Angiogenic patterns are associated with high-gradein situ ductal carcinomas of the breast

1997 • 110 citations

Tumours acquire their vasculature by vessel incorporation, not vessel ingrowth

1987 • 89 citations

Angiogenesis and Neoplastic Progression In Vitro<xref ref-type="fn" rid="fn2">2</xref>

1982 • 86 citations

Tumor Angiogenesis and Polyamines: α-Difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits B16 Melanoma-induced Angiogenesis in Ovo and the Proliferation of Vascular Endothelial Cells in Vitro

1990 • 80 citations

Thymidine phosphorylase activity of platelet‐derived endothelial cell growth factor is responsible for endothelial cell mitogenicity

1993 • 76 citations

Acquisition of angiogenic capacity and neoplastic transformation in the rat mammary gland.

1978 • 64 citations

Platelet-derived endothelial cell growth factor

1991 • 51 citations

The activities of thymidine metabolising enzymes during the cell cycle of a human lymphocyte cell line LAZ-007 synchronised by centrifugal elutriation

1980 • 45 citations

MICROVESSEL QUANTIFICATION AS A MEASURE OF ANGIOGENIC ACTIVITY IN BENIGN BREAST TISSUES LESIONS - A MARKER FOR PRECANCEROUS DISEASE

1994 • 26 citations

DNA precursors are channelled to nuclear matrix DNA replication sites

1993 • 22 citations

Induction of thymidine kinase activity and clonal growth of certain leukemic cell lines by a granulocyte-derived factor

1990 • 14 citations