J-104,871, a Novel Farnesyltransferase Inhibitor, Blocks Ras FarnesylationIn Vivoin a Farnesyl Pyrophosphate-Competitive Manner

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

1997 • 1,482 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

1975 • 747 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

1995 • 393 citations

Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo

1997 • 361 citations

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

1993 • 331 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

Polylysine and CVIM Sequences of K-RasB Dictate Specificity of Prenylation and Confer Resistance to Benzodiazepine Peptidomimetic in Vitro

1995 • 285 citations

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

1993 • 257 citations

ras oncogenes: their role in neoplasia

1990 • 244 citations

Steady-state kinetic mechanism of ras farnesyl:protein transferase

1992 • 242 citations

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956.

1995 • 241 citations

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

1995 • 226 citations

ras and human tumors.

1992 • 224 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I

1997 • 203 citations

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions

1991 • 168 citations

Novel Tricyclic Inhibitors of Farnesyl Protein Transferase

1995 • 157 citations

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.

1996 • 152 citations

NB-598: a potent competitive inhibitor of squalene epoxidase.

1990 • 107 citations

Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.

1994 • 59 citations

C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

1997 • 27 citations

A New Class of Highly Potent Farnesyl Diphosphate-Competitive Inhibitors of Farnesyltransferase

1998 • 26 citations

Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase

1995 • 19 citations

J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs

1996 • 17 citations