Steady-state kinetic mechanism of ras farnesyl:protein transferase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

1963 • 29,357 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Sequence dependence of protein isoprenylation

1991 • 580 citations

Posttranslational modification of proteins by isoprenoids in mammalian cells

1990 • 515 citations

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1990 • 465 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

1990 • 389 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

1991 • 312 citations

A solubilizable acrylamide gel for electrophoresis

1970 • 275 citations

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.

1990 • 230 citations

G protein gamma subunits contain a 20-carbon isoprenoid.

1990 • 229 citations

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

1990 • 222 citations

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.

1991 • 221 citations

Biochemistry of Cell Walls and Membranes in Fungi

1990 • 200 citations

Yeast and mammalian ras proteins have conserved biochemical properties

1985 • 195 citations

The gamma subunit of transducin is farnesylated.

1990 • 187 citations

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

1991 • 183 citations

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions

1991 • 168 citations

cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

1991 • 166 citations

Specificity and kinetics of triose phosphate isomerase from chicken muscle

1972 • 109 citations

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

1989 • 106 citations

Initial rate enzyme kinetics

1976 • 98 citations

Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.

1991 • 92 citations

Farnesylpyrophosphate synthetase. A stepwise mechanism for the 1'-4 condensation reaction

1981 • 89 citations

Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase

1988 • 85 citations

Farnesyl pyrophosphate synthetase. Mechanistic studies of the 1'-4 coupling reaction with 2-fluorogeranyl pyrophosphate.

1978 • 84 citations

A novel prenyltransferase for a small GTP-binding protein having a C-terminal Cys-Ala-Cys structure.

1991 • 69 citations

A continuous spectrophotometric assay for argininosuccinate synthetase based on pyrophosphate formation

1976 • 68 citations

Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate.

1990 • 68 citations

Mechanism of the prenyl transfer reaction. Studies with (E)- and (Z)-3-trifluoromethyl-2-buten-1-yl pyrophosphate

1977 • 67 citations

Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein

1990 • 63 citations

Squalene synthetase, inhibition by ammonium analogs of carbocationic intermediates in the conversion of presqualene diphosphate to squalene

1989 • 61 citations

Squalene Synthetase

1973 • 60 citations

In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues

1991 • 37 citations

Prenyltransferase. Kinetic studies of the 1'-4 coupling reaction with avian liver enzyme.

1979 • 33 citations

Novel phosphonylphosphinyl (P-C-P-C-) analogs of biochemically interesting diphosphates. Syntheses and properties of P-C-P-C-, analogs of isopentenyl diphosphate and dimethylallyl diphosphate

1987 • 30 citations

Molecular genetics in cancer diagnosis

1990 • 26 citations