Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

SH2 and SH3 domains

1993 • 697 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein

1978 • 673 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

The when and how of Src regulation

1993 • 543 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Constitutive activation of Src family kinases in mouse embryos that lack Csk

1993 • 401 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

1993 • 331 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

A Protein Tyrosine Kinase Involved in Regulation of pp60c-src function

1989 • 309 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Association of p60c-src with endosomal membranes in mammalian fibroblasts.

1992 • 233 citations

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

1991 • 224 citations

Osteoclasts express high levels of pp60c-src in association with intracellular membranes.

1992 • 221 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

1992 • 179 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

Characterization of cDNA clones for the human c-yes gene.

1987 • 147 citations

Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells.

1988 • 145 citations

Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.

1993 • 132 citations

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.

1994 • 132 citations

p60c-src activity detected in the chromaffin granule membrane

1986 • 109 citations

Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein.

1992 • 100 citations

Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.

1992 • 87 citations

Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.

1990 • 85 citations

Purification and enzymatic characterization of pp60c-src from human platelets.

1990 • 85 citations

Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

1993 • 85 citations

Structure, expression, and chromosomal location of the human c-fgr gene.

1986 • 81 citations

Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns

1992 • 73 citations

cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).

1991 • 71 citations

Palmitylation of an Amino-Terminal Cysteine Motif of Protein Tyrosine Kinases p56^lckand p59^fynMediates Interaction With Glycosyl-Phosphatidylinositol-Anchored Proteins

1993 • 66 citations

The cell cycle and c-Src

1993 • 66 citations

Membrane interactions of pp60v-src: a model for myristylated tyrosine protein kinases.

1990 • 54 citations

Effects of SH2 and SH3 Deletions on the Functional Activities of Wild-Type and Transforming Variants of c-Src

1992 • 53 citations

Site-Directed Mutagenesis of the SH2- and SH3-Coding Domains of c-src Produces Varied Phenotypes, Including Oncogenic Activation of p60^c-src

1990 • 47 citations

Identification of a novel protein tyrosine kinase that phosphorylates pp60c-src and regulates its activity in neonatal rat brain

1988 • 45 citations

Protein Tyrosine Kinase in Rat Brain: Neonatal Rat Brain Expresses Two Types of pp60c-src and a Novel Protein Tyrosine Kinase1

1988 • 38 citations

Characterization of cDNA Clones for the Human c-yes Gene

1987 • 38 citations

Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).

1993 • 37 citations

Activation of the Proto-Oncogene p60^c-src by Point Mutations in the SH2 Domain

1990 • 35 citations

[53] Production of p60c-src by baculovirus expression and immunoaffinity purification

1991 • 33 citations

Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference

1989 • 29 citations

Tyrosine Phosphorylation of CD45 Phosphotyrosine Phosphatase by p50^csk Kinase Creates A Binding Site for p56^lck Tyrosine Kinase and Activates the Phosphatase

1994 • 29 citations

Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase

1992 • 29 citations

Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases

1992 • 29 citations

High-yield purification of a pp60c-src related protein-tyrosine kinase from human platelets

1988 • 28 citations

Suppression of c-Src Activity by C-Terminal Src Kinase Involves the c-Src SH2 and SH3 Domains: Analysis with Saccharomyces cerevisiae

1993 • 26 citations

Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527.

1993 • 21 citations

Transformation of Chicken Embryo Fibroblast Cells by Avian Retroviruses Containing the Human Fyn Gene and Its Mutated Genes

1990 • 19 citations

Structure, Expression, and Chromosomal Location of the Human c-fgr Gene

1986 • 19 citations

Deleted Work

1955 • 0 citations