PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1991 • 1,321 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia.

1994 • 293 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow

1996 • 258 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

Sustained Activation of the Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway Is Required for Megakaryocytic Differentiation of K562 Cells

1997 • 184 citations

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation

1997 • 155 citations

Induced differentiation of K562 leukemia cells: A model for studies of gene expression in early megakaryoblasts

1990 • 155 citations

Inducers of erythroid differentiation in K562 human leukemia cells.

1981 • 151 citations

The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells

1996 • 142 citations

Leukocyte integrin P150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium.

1991 • 137 citations

The Product of the cbl Oncogene Forms Stable Complexes In Vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner

1996 • 117 citations

Phorbol ester induces c-sis gene transcription in stem cell line K-562.

1986 • 115 citations

Enhancement of Guanine-Nucleotide Exchange Activity of C3G for Rap1 by the Expression of Crk, CrkL, and Grb2

1997 • 105 citations

Antisense SCL suppresses self-renewal and enhances spontaneous erythroid differentiation of the human leukaemic cell line K562.

1991 • 89 citations

Activation of the Mitogen-Activated Protein Kinase Pathway Is Involved in and Sufficient for Megakaryocytic Differentiation of CMK Cells

1997 • 80 citations

Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues.

1987 • 72 citations

Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells

1996 • 70 citations

Inhibition of abl Oncogene Tyrosine Kinase Induces Erythroid Differentiation of Human Myelogenous Leukemia K562 Cells

1990 • 62 citations

Phosphotyrosine Antibodies Identify the p210^c-abl Tyrosine Kinase and Proteins Phosphorylated on Tyrosine in Human Chronic Myelogenous Leukemia Cells

1986 • 60 citations

Reduction in protein tyrosine phosphorylation during differentiation of human leukemia cell line K-562.

1987 • 39 citations

Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced differentiation of a human megakaryoblastic cell line, MEG-O1

1991 • 31 citations

Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation.

1994 • 29 citations

A 41-kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells.

1992 • 13 citations