Phosphotyrosine Antibodies Identify the p210^c-abl Tyrosine Kinase and Proteins Phosphorylated on Tyrosine in Human Chronic Myelogenous Leukemia Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Acute Myelogenous Leukemia: A Human Cell Line Responsive to Colony-Stimulating Activity

1978 • 537 citations

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

1980 • 474 citations

Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product

1980 • 420 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine

1980 • 328 citations

Chromosomal localization of human cellular homologues of two viral oncogenes

1982 • 304 citations

Membranes of animal cells. I. Methods of isolation of the surface membrane

1966 • 290 citations

Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.

1985 • 282 citations

Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

1981 • 277 citations

Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells.

1978 • 266 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

The mouse c-abl locus: Molecular cloning and characterization

1984 • 223 citations

An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.

1984 • 210 citations

Altered Transcription of the c- abl Oncogene in K-562 and Other Chronic Myelogenous Leukemia Cells

1984 • 209 citations

Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.

1984 • 209 citations

Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.

1984 • 207 citations

Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten

1981 • 203 citations

Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.

1983 • 200 citations

The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity

1985 • 184 citations

Four Different Classes of Retroviruses Induce Phosphorylation of Tyrosines Present in Similar Cellular Proteins

1981 • 178 citations

Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblasts.

1980 • 169 citations

Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation

1983 • 165 citations

Regulation of Cell Growth and Transformation by Tyrosine-Specific Protein Kinases: The Search for Important Cellular Substrate Proteins

1983 • 164 citations

Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein.

1985 • 163 citations

Use of an antiserum against phosphotyrosine for the identification of phosphorylated components in human fibroblasts stimulated by platelet-derived growth factor.

1984 • 163 citations

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

1985 • 162 citations

Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies.

1984 • 147 citations

The 34 kd pp60src substrate is located at the inner face of the plasma membrane

1983 • 142 citations

A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity.

1980 • 132 citations

Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components.

1978 • 132 citations

Cell surface molecules and fibronectin-mediated cell adhesion: effect of proteolytic digestion of membrane proteins.

1982 • 127 citations

Cellular RNA homologous to the Abelson murine leukemia virus transforming gene: expression and relationship to the viral sequence.

1983 • 124 citations

Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity

1984 • 119 citations

Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine.

1981 • 113 citations

Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation

1980 • 101 citations

Membrane association of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses.

1983 • 89 citations

In vivo tyrosine phosphorylations of the abelson virus transforming protein are absent in its normal cellular homolog

1982 • 86 citations

Abelson murine leukemia virus transformation-defective mutants with impaired P120-associated protein kinase activity

1980 • 69 citations

Changes in the distribution of the 34-kdalton tyrosine kinase substrate during differentiation and maturation of chicken tissues.

1984 • 69 citations

The Hardy–Zuckerman 2-FeSV, a new feline retrovirus with oncogene homology to Abelson-MuLV

1983 • 65 citations

In vivo phosphorylation and dephosphorylation of the platelet-derived growth factor receptor studied by immunoblot analysis with phosphotyrosine antibodies

1986 • 52 citations

Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrate.

1983 • 27 citations

Some Lymphoid Cell Lines Transformed by Abelson Murine Leukemia Virus Lack a Major 36,000-Dalton Tyrosine Protein Kinase Substrate

1983 • 10 citations