The Thymus: Clock for Immunologic Aging?

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Handbook of the Biology of Aging

1978 • 871 citations

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

1975 • 758 citations

AGEING, IMMUNE RESPONSE, AND MORTALITY

1974 • 480 citations

Subpopulations of Human T Cells Identified by Receptors for Immunoglobulins and Mitogen Responsiveness

1976 • 430 citations

EPIDEMIOLOGIC AND IMMUNOLOGIC SIGNIFICANCE OF AGE DISTRIBUTION OF ANTIBODY TO ANTIGENIC VARIANTS OF INFLUENZA VIRUS

1953 • 390 citations

Changes in Blood Hormone Levels during the Immune Response

1975 • 342 citations

THE ORIGIN OF MACROPHAGES FROM BONE MARROW IN THE RAT.

1965 • 339 citations

PRIMARY IMMUNODEFICIENCIES

1971 • 336 citations

Morphological and histochemical analyses of two human T-cell subpopulations bearing receptors for IgM or IgG.

1978 • 329 citations

MALIGNANT TUMORS ARISING DE NOVO IN IMMUNOSUPPRESSED ORGAN TRANSPLANT RECIPIENTS

1972 • 305 citations

Influence of Brain and Behavior on the Immune System

1976 • 291 citations

Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans

1973 • 286 citations

Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated mice

1964 • 276 citations

Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice.

1976 • 239 citations

Longevity and Gross Pathology At Death in 22 Inbred Mouse Strains

1966 • 222 citations

Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?

1974 • 205 citations

Mitogenic Effect of Phytohaemagglutinin at Different Ages

1967 • 204 citations

Thymic Involution: Effect on T Cell Differentiation

1975 • 183 citations

Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies.

1972 • 177 citations

Lymphocytes, Hormones and Ageing

1972 • 149 citations

Immunological studies of Aging. III. Cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins.

1977 • 146 citations

Immunological defect in aged population and its relationship to cancer

1965 • 145 citations

Genetically determined immune deficiency as the predisposing cause of “autoimmunity” and lymphoid neoplasia

1971 • 138 citations

Delayed Effect of Thymectomy in Adult Life on Immunological Competence

1965 • 137 citations

Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.

1973 • 134 citations

Codon-restriction theory of aging and development

1971 • 124 citations

Humoral immunity in aged mice. II. Increased suppressor T cell activity in immunologically deficient old mice.

1976 • 124 citations

Decay of Immunological Responsiveness after Thymectomy in Adult Life

1965 • 123 citations

Influence of the main histocompatibility complex on ageing in mice

1977 • 120 citations

Ageing and Immunological Function in Man

1972 • 118 citations

Age-Related Decrease in Mouse T Cell Progenitors

1977 • 115 citations

Immunobiology of aging: Evaluation of current status

1976 • 115 citations

Decline in Phytohemagglutinin Responsiveness of Spleen Cells from Aging Mice

1973 • 109 citations

Effects of aging on the differentiation and proliferation potentials of cells of the immune system.

1975 • 108 citations

Decline in Mixed Lymphocyte Reactivity of Spleen Cells from Aged Mice of a Long-Lived Strain

1973 • 99 citations

Decline in the growth potential of spleen-colonizing bone marrow stem cells of long-lived aging mice.

1976 • 94 citations

Growth and senescence of antibody-forming cells

1966 • 94 citations

DECREASE OF T LYMPHOCYTES DURING AGEING

1974 • 94 citations

Effect of age on cell-mediated immunity in long-lived mice.

1975 • 93 citations

Supressor Cells in the Graft vs Host Reaction

1973 • 88 citations

Age-Related Decline in Response to Phytohemagglutinin and Pokeweed Mitogen by Spleen Cells from Hamsters and a Long-Lived Mouse Strain

1973 • 87 citations

Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity.

1970 • 87 citations

Age-Related Changes in T Cell Function

1977 • 85 citations

RELATIVE ANTIBODY-FORMING CAPACITY OF SPLEEN CELLS AS A FUNCTION OF AGE

1962 • 84 citations

The effect of aging and acute illness on delayed hypersensitivity

1975 • 83 citations

Age-Related Changes in Cell-Mediated Immunity in BALB/C Mice

1975 • 82 citations

Deficient Immunologic Functions of NZB Mice

1968 • 81 citations

Age‐related changes in hematopoietic stem cell populations of a long‐lived hybrid mouse

1971 • 79 citations

Rosette-forming T cells in human peripheral blood at different ages

1974 • 78 citations

Association of autoimmunity, immunodeficiency and aging in man, rabbits, and mice.

1974 • 72 citations

Effect of Age upon Primary Alloantigen Recognition by Mouse Spleen Cells

1971 • 68 citations

Presence of Impairment of Humoral Immunity in Nonadherent Spleen Cells of Old Mice

1973 • 62 citations

Change of Cell-Mediated Cytotoxicity with Aging

1975 • 59 citations

Quantitative Immunoelectrophoresis of Proteins in Serum from a Normal Population: Season-, Age-, and Sex-related Variations

1971 • 58 citations

Effects of aging on the differentiation and proliferation potentials of cells of the immune system

1975 • 57 citations

Lymphocyte responses to phytohaemagglutinin: age-related effects.

1976 • 56 citations

Antigen-induced locomotor responses in lymphocytes.

1977 • 54 citations

Age-related decline in the resistance of mice to infection with intracellular pathogens

1977 • 54 citations

Thymus-dependent recersibility of physiological and isoproterenol evoked age-related parameters in athymic (nude) and old normal mice

1978 • 53 citations

Regulation of stem cell renewal and differentiation: possible significance in aging.

1971 • 51 citations

Reducèd in vitro response to concanavalin A and lipopolysaccharide in senescent mice: a function of reduced number of responding cells

1977 • 50 citations

AGE-RELATED CHANGES IN T AND B CELLS

1975 • 50 citations

Circulating suppressor cells in man as a function of age

1978 • 50 citations

Influence of Thymus Cells on Erythropoiesis of Parental Marrow in Irradiated Hybrid Mice

1968 • 47 citations

Effect of age on response to T- and B-cell mitogens in mice congenic at theH-2 locus

1977 • 47 citations

A TUBERCULIN SURVEY OF 1285 ADULTS

1957 • 47 citations

In Australia now.

1976 • 46 citations

Stem Cell Lines from Old Immunodeficient Donors Give Normal Responses in Young Recipients

1977 • 46 citations

The Thymus and Aging

1977 • 46 citations

Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice

1975 • 44 citations

Age-related refractoriness of PHA-induced lymphocyte transformation. II. 125I-PHA binding to spleen cells from young and old mice

1975 • 43 citations

The growth and involution of lymphatic tissue and its interrelationships to aging and to the growth of the adrenal glands and sex organs in CBA mice

1960 • 38 citations

Age-Associated Decline in the in Vitro Development of Cytotoxic Lymphocytes in NZB Mice

1976 • 36 citations

Age-associated decline in theta antigen on spleen thymus-derived lymphocytes of B6CF1 mice

1975 • 36 citations

The Immune Systems of Mice Reared in Clean and in Dirty Conventional Laboratory Farms. I. Life Expectancy and Pathology of Mice with Long Life-Spans

1971 • 35 citations

Effect of age on T cell differentiation.

1978 • 35 citations

Age-related changes in the cellular immune response of lymph node and thymus cells in long-lived mice

1975 • 32 citations

Increase in autologous erythrocyte binding by T cells with ageing in man.

1977 • 31 citations

Cellular changes with age

1952 • 30 citations

Aging and Cancerigenesis. II. Effect of Age on Phagocytic Activity of the Reticuloendothelial System and on Tumor Growth2

1965 • 30 citations

The Immunoepidemiology of Aging

1977 • 28 citations

Regulation of the immune system by synthetic polynucleotides. VI. Amplification of the immune response in young and aging mice.

1976 • 28 citations

A multiple-parameter comparison of immunocompetence and tumor resistance in aged BALB/c mice

1977 • 28 citations

The Immune Systems of Mice Reared in Clean and in Dirty Conventional Laboratory Farms. II. Primary Antibody-Forming Activity of Young and Old Mice with Long Life-Spans

1971 • 28 citations

Hypopituitary dwarf and athymic nude mice and the study of the relationships among thymus, hormones, and aging.

1978 • 27 citations

Aging: alteration of DNA-protein information.

1973 • 27 citations

Possible Immune Origin of Age-Related Pathological Changes in Long-Lived Mice

1973 • 26 citations

Aging: Alteration of DNA-Protein Information

1973 • 25 citations

Restoration of ability to reject xenografts and clear carbon after hypophysectomy of adult rats

1977 • 25 citations

Antibody Production and Development of Contact Skin Sensitivity in Guinea Pigs of Various Ages

1963 • 25 citations

Strain-, Age-, and Tumor-Dependent Distribution of Terminal Deoxynucleotidyl Transferase in Thymocytes of Mice

1976 • 25 citations

An Improved Primary Response from Mouse Spleen Cells Cultured in Vivo in Diffusion Chambers

1972 • 25 citations

Hormones and Aging

1977 • 25 citations

Murine Leukemia: A Virus-Induced Autoimmune Disease?

1973 • 23 citations

Decline and Restoration of Antibody-Forming Capacity in Aging Beagle Dogs

1974 • 21 citations

Cytochemical study of human lymphocytes stimulated by PHA in function of donor age

1978 • 21 citations

Synthetic polynucleotides as restorers of normal antibody-forming capacities in aged mice.

1970 • 20 citations

Inability of thymus cells from newborn donors to restore transplantation immunity in athymic mice.

1975 • 20 citations

Aging and cancerigenesis. 3. Effect of age on isoantibody formation.

1966 • 20 citations

SEZARY SYNDROME

1974 • 20 citations

Arteriosclerosis: Is Stress-Induced Immune Suppression a Risk Factor?

1977 • 15 citations

The mixed lymphocyte response of senescent mice: Sensitivity to alloantigen and cell replication time

1977 • 15 citations

A Tuberculin Survey of 1,285 Adults with Special Reference to the Elderly.

1957 • 11 citations

Tuberculin Skin Testing in a Chronically Sick Aged Population

1972 • 10 citations

Suppressor Cells in Aging

1977 • 10 citations

Changes in immunological potential between juvenile and presenile in rabbit

1976 • 9 citations

Deleted Work

1955 • 0 citations

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